Show simple item record

2023-05-30Zeitschriftenartikel
Molecular epidemiology and disease severity of influenza virus infection in patients with haematological disorders
dc.contributor.authorÜnal, Silan
dc.contributor.authorSchnitzler, Paul
dc.contributor.authorGiesen, Nicola
dc.contributor.authorWedde, Marianne
dc.contributor.authorDürrwald, Ralf
dc.contributor.authorTabatabai, Julia
dc.date.accessioned2023-11-16T13:24:15Z
dc.date.available2023-11-16T13:24:15Z
dc.date.issued2023-05-30none
dc.identifier.other10.1002/jmv.28835
dc.identifier.urihttp://edoc.rki.de/176904/11359
dc.description.abstractnfluenza virus infection is a common cause of self‐limiting respiratory tract infection(RTI), however immunocompromised patients are at an increased risk for a severecourse of disease or fatal outcome. We therefore aimed to gain a betterunderstanding of the molecular epidemiology of influenza viruses from patientswith haematological disorders and their impact on the clinical course of disease.Molecular analysis using polymerase chain reaction (PCR) of nasopharyngeal swabswas performed for influenza virus in haematological patients at the HeidelbergUniversity Hospital. Clinical data was evaluated to identify associated risk factors.For phylogenetic analysis, the hemagglutinin (HA) gene was sequenced. Out of 159influenza positive patients, 117 patients developed upper RTI (influenza A:n= 73;influenza B:n= 44). Lower RTI was observed inn= 42 patients (26%),n= 22/42patients developed severe disease andn= 16/159 (10.1%) patients died. Risk factorsfor lower RTI were nosocomial infection (p= 0.02), viral shedding for≥14 days(p= 0.018), IgG levels <6 g/dL (p= 0.046), bacterial/fungal co‐infections (p< 0.001).Risk factors for fatal outcome were age≥65 years (p= 0.032), bacterial/fungal(p≤0.001) co‐infections and high viral load (p= 0.026). Sequencing of the HA gene(n= 115) revealed subtype A(H3N2) (n= 46), A(H1N1)pdm09 (n= 24), B/Victoria(n= 34), B/Yamagata (n= 11). There was no correlation between influenza (sub)typeand lower RTI. Influenza infection in haematological patients is associated withsignificant morbidity and mortality, the risk for aggravating co‐infections, prolongedviral shedding and nosocomial transmission emphasizing the need for infectioncontrol.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC-ND 3.0 DE) Namensnennung - Nicht-kommerziell - Keine Bearbeitung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/de/
dc.subjecthaematologic disordereng
dc.subjectinfluenza viruseng
dc.subjectmolecular epidemiologyeng
dc.subjectrisk factorseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleMolecular epidemiology and disease severity of influenza virus infection in patients with haematological disordersnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11359-6
dc.type.versionpublishedVersionnone
local.edoc.container-titleJournal o Medical Virologynone
local.edoc.container-issn1096-9071none
local.edoc.pages14none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://onlinelibrary.wiley.com/journal/10969071none
local.edoc.container-publisher-nameWileynone
local.edoc.container-volume95none
local.edoc.container-issue6none
local.edoc.container-reportyear2023none
dc.description.versionPeer Reviewednone

Show simple item record