Zur Kurzanzeige

2003-01-01Zeitschriftenartikel DOI: 10.1084/jem.20020632
Expression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10
dc.contributor.authorLöhning, Max
dc.contributor.authorHutloff, Andreas
dc.contributor.authorKallinich, Tilmann
dc.contributor.authorMages, Hans Werner
dc.contributor.authorBonhagen, Kerstin
dc.contributor.authorRadbruch, Andreas
dc.contributor.authorHamelmann, Eckard
dc.contributor.authorKroczek, Richard
dc.date.accessioned2018-05-07T17:29:53Z
dc.date.available2018-05-07T17:29:53Z
dc.date.created2014-02-17
dc.date.issued2003-01-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reZDtDvZJCtYs/PDF/24MnYr7pUsddk.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1821
dc.description.abstractThe studies performed to date analyzed the overall participation of the inducible costimulator (ICOS) in model diseases, but did not yield information on the nature and function of ICOS-expressing T cells in vivo. We examined ICOS+ T cells in the secondary lymphoid organs of nonmanipulated mice, in the context of an “unbiased” immune system shaped by environmental antigens. Using single cell analysis, ICOSlow cells were found to be loosely associated with the early cytokines interleukin (IL)-2, IL-3, IL-6, and interferon (IFN)-γ. ICOSmedium cells, the large majority of ICOS+ T cells in vivo, were very tightly associated with the synthesis of the T helper type 2 (Th2) cytokines IL-4, IL-5, and IL-13, and these cells exhibited potent inflammatory effects in vivo. In contrast, ICOShigh T cells were highly and selectively linked to the anti-inflammatory cytokine IL-10. Overall, these data seem to indicate that ICOS cell surface density serves as a regulatory mechanism for the release of cytokines with different immunological properties. Further in vivo functional experiments with in vitro–activated T cells strongly suggested that the ICOS+ population, although representing in vivo only around 10% of T cells bearing early or late activation markers, nevertheless encompasses virtually all effector T cells, a finding with major diagnostic and therapeutic implications.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectInbred BALB Ceng
dc.subjectDifferentiationeng
dc.subjectAnimalseng
dc.subjectMiceeng
dc.subjectPhenotypeeng
dc.subjectAdoptive Transfereng
dc.subjectAnti-Inflammatory Agents/metabolismeng
dc.subjectAntigenseng
dc.subjectT-Lymphocyte/geneticseng
dc.subjectT-Lymphocyte/metabolism*eng
dc.subjectCD4-Positive T-Lymphocytes/immunology*eng
dc.subjectCytokines/biosynthesiseng
dc.subjectInducible T-Cell Co-Stimulator Proteineng
dc.subjectInflammation/etiology*eng
dc.subjectInflammation/immunologyeng
dc.subjectInflammation Mediators/metabolismeng
dc.subjectInterleukin-10/biosynthesis*eng
dc.subjectLymphocyte Activationeng
dc.subjectLymphoid Tissue/immunologyeng
dc.subjectTransgeniceng
dc.subjectOvalbumin/immunologyeng
dc.subjectTh2 Cells/immunologyeng
dc.subject.ddc610 Medizin
dc.titleExpression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10035092
dc.identifier.doi10.1084/jem.20020632
dc.identifier.doihttp://dx.doi.org/10.25646/1746
local.edoc.container-titleJournal of Experimental Medicine
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://jem.rupress.org/content/197/2/181
local.edoc.container-publisher-nameRockefeller University Press
local.edoc.container-volume197
local.edoc.container-issue2
local.edoc.container-year2003

Zur Kurzanzeige