Zur Kurzanzeige

2016-03-01Zeitschriftenartikel DOI: 10.25646/2318
Assessment of Recombination in the S-segment Genome of Crimean-Congo Hemorrhagic Fever Virus in Iran
dc.contributor.authorChinikar, Sadegh
dc.contributor.authorShah-Hosseini, Nariman
dc.contributor.authorBouzari, Saeid
dc.contributor.authorShokrgozar, Mohammad Ali
dc.contributor.authorMostafavi, Ehsan
dc.contributor.authorJalali, Tahmineh
dc.contributor.authorKhakifirouz, Sahar
dc.contributor.authorGroschup, Martin H.
dc.contributor.authorNiedrig, Matthias
dc.date.accessioned2018-05-07T19:15:35Z
dc.date.available2018-05-07T19:15:35Z
dc.date.created2016-08-10
dc.date.issued2016-03-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reGD99wcaV1A/PDF/27j1gATTcZSHE.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2393
dc.description.abstractBackground: Crimean-Congo Hemorrhagic Fever Virus (CCHFV) belongs to genus Nairovirus and family Bunyaviridae. The main aim of this study was to investigate the extent of recombination in S-segment genome of CCHFV in Iran. Methods: Samples were isolated from Iranian patients and those available in GenBank, and analyzed by phyloge­netic and bootscan methods. Results: Through comparison of the phylogenetic trees based on full length sequences and partial fragments in the S-segment genome of CCHFV, genetic switch was evident, due to recombination event. Moreover, evidence of multi­ple recombination events was detected in query isolates when bootscan analysis was used by SimPlot software. Conclusion: Switch of different genomic regions between different strains by recombination could contribute to CCHFV diversification and evolution. The occurrence of recombination in CCHFV has a critical impact on epidemi­ological investigations and vaccine design.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Biologische Sicherheit
dc.subjectPhylogeneticeng
dc.subjectRecombinationeng
dc.subjectDiversityeng
dc.subjectCrimean Congo Hemorrhagic Fevereng
dc.subjectIraneng
dc.subject.ddc610 Medizin
dc.titleAssessment of Recombination in the S-segment Genome of Crimean-Congo Hemorrhagic Fever Virus in Iran
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10046431
dc.identifier.doihttp://dx.doi.org/10.25646/2318
local.edoc.container-titleJournal of Arthropod-Borne Diseases
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://jad.tums.ac.ir/index.php/jad/article/view/288
local.edoc.container-publisher-nameTehran University of Medical Sciences
local.edoc.container-volume10
local.edoc.container-issue1
local.edoc.container-year2016

Zur Kurzanzeige