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2016-03-01Zeitschriftenartikel DOI: 10.25646/2318
Assessment of Recombination in the S-segment Genome of Crimean-Congo Hemorrhagic Fever Virus in Iran
Chinikar, Sadegh
Shah-Hosseini, Nariman
Bouzari, Saeid
Shokrgozar, Mohammad Ali
Mostafavi, Ehsan
Jalali, Tahmineh
Khakifirouz, Sahar
Groschup, Martin H.
Niedrig, Matthias
Background: Crimean-Congo Hemorrhagic Fever Virus (CCHFV) belongs to genus Nairovirus and family Bunyaviridae. The main aim of this study was to investigate the extent of recombination in S-segment genome of CCHFV in Iran. Methods: Samples were isolated from Iranian patients and those available in GenBank, and analyzed by phyloge­netic and bootscan methods. Results: Through comparison of the phylogenetic trees based on full length sequences and partial fragments in the S-segment genome of CCHFV, genetic switch was evident, due to recombination event. Moreover, evidence of multi­ple recombination events was detected in query isolates when bootscan analysis was used by SimPlot software. Conclusion: Switch of different genomic regions between different strains by recombination could contribute to CCHFV diversification and evolution. The occurrence of recombination in CCHFV has a critical impact on epidemi­ological investigations and vaccine design.
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DOI
10.25646/2318
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http://dx.doi.org/10.25646/2318
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<a href="http://dx.doi.org/10.25646/2318">http://dx.doi.org/10.25646/2318</a>