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Auflistung Artikel in Fachzeitschriften nach Autor "Aebischer, Toni"
Anzeige der Publikationen 1-20 von 31
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2017-05-12ZeitschriftenartikelA third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH Osman, Mohamed; Mistry, Anoop; Keding, Ada; Gabe, Rhian; Cook, Elizabeth; Forrester, Sarah; Wiggins, Rebecca; Marco, Stefania Di; Colloca, Stefano; Siani, Loredana; Cortese, Riccardo; Smith, Deborah F.; Aebischer, Toni; Kaye, Paul M.Background: Visceral leishmaniasis (VL or kala azar) is the most serious form of human leishmaniasis, responsible for over 20,000 deaths annually, and post kala azar dermal leishmaniasis (PKDL) is a stigmatizing skin ...
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2016-11-14ZeitschriftenartikelAsymptomatic only at first sight: malaria infection among schoolchildren in highland Rwanda Sifft, Kevin C.; Geus, Dominik; Mukampunga, Caritas; Mugisha, Jean Claude; Habarugira, Felix; Fraundorfer, Kira; Bayingana, Claude; Ndoli, Jules; Umulisa, Irenee; Karema, Corine; Samson-Himmelstjerna, George von; Aebischer, Toni; Martus, Peter; Sendegeya, Augustin; Gahutu, Jean Bosco; Mockenhaupt, Frank P.Background: Plasmodium infection and malaria in school children are increasingly recognized as a relevant public health problem, but data on actual prevalence and health consequences are insufficient. The present study ...
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2017-03-27ZeitschriftenartikelChanges to cholesterol trafficking in macrophages by Leishmania parasites infection Semini, Geo; Paape, Daniel; Paterou, Athina; Schroeder, Juliane; Barrios-Llerena, Martin; Aebischer, ToniLeishmania spp. are protozoan parasites that are transmitted by sandfly vectors during blood sucking to vertebrate hosts and cause a spectrum of diseases called leishmaniases. It has been demonstrated that host cholesterol ...
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2018-05-18ZeitschriftenartikelComment on “The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans” Krücken, Jürgen; Fraundorfer, Kira; Mugisha, Jean Claude; Ramünke, Sabrina; Sifft, Kevin C.; Geus, Dominik; Habarugira, Felix; Ndoli, Jules; Sendegeya, Augustin; Mukampunga, Caritas; Aebischer, Toni; McKay-Demeler, Janina; Gahutu, Jean Bosco; Mockenhaupt, Frank P.; von Samson-Himmelstjerna, GeorgA recent publication by Levecke et al. (Int. J. Parasitol, 2018, 8, 67–69) provides important insights into the kinetics of worm expulsion from humans following treatment with albendazole. This is an important aspect of ...
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2011-05-19ZeitschriftenartikelContribution of proteomics of Leishmania spp. to the understanding of differentiation, drug resistance mechanisms, vaccine and drug development Paape, Daniel; Aebischer, ToniLeishmania spp., protozoan parasites with a digenetic life cycle, cause a spectrum of diseases in humans. Recently several Leishmania spp. have been sequenced which significantly boosted the number and quality of proteomic ...
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2010-10-31ZeitschriftenartikelDirect Visualization of Peptide/MHC Complexes at the Surface and in the Intracellular Compartments of Cells Infected In Vivo by Leishmania major Muraille, Eric; Gounon, Pierre; Cazareth, Julie; Hoebeke, Johan; Lippuner, Christoph; Davalos-Misslitz, Ana; Aebischer, Toni; Muller, Sylviane; Glaichenhaus, Nicolas; Mougneau, EvelyneProtozoa and bacteria infect various types of phagocytic cells including macrophages, monocytes, dendritic cells and eosinophils. However, it is not clear which of these cells process and present microbial antigens in vivo ...
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2021-11-23ZeitschriftenartikelDissection of Barrier Dysfunction in Organoid-Derived Human Intestinal Epithelia Induced by Giardia duodenalis Holthaus, David; Kraft, Martin R.; Krug, Susanne M.; Wolf, Silver; Müller, Antonia; Delgado-Betancourt, Estefanía; Schorr, Madeleine; Holland, Gudrun; Knauf, Felix; Schulzke, Joerg-Dieter; Aebischer, Toni; Klotz, ChristianBACKGROUND & AIMS: The protozoa Giardia duodenalis is a major cause of gastrointestinal illness worldwide, but un- derlying pathophysiological mechanisms remain obscure, partly due to the absence of adequate cellular ...
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2018-02-02ZeitschriftenartikelEditorial: Parasite Infections: From Experimental Models to Natural Systems Aebischer, Toni; Matuschewski, Kai; Hartmann, Susanne
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2014-07-11ZeitschriftenartikelEpidemiology of Giardia duodenalis infection in ruminant livestock and children in the Ismailia province of Egypt: insights by genetic characterization Helmy, Yosra A.; Klotz, Christian; Wilking, Hendrik; Krücken, Jürgen; Nöckler, Karsten; Samson-Himmelstjerna, Georg von; Zessin, Karl-H.; Aebischer, ToniBackground: Giardia duodenalis is a common flagellated protozoan parasite that infects the small intestine of a wide range of vertebrate hosts. This study aimed to determine whether tracing of G. duodenalis isolates by ...
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2015-09-24ZeitschriftenartikelFirst Draft Genome Sequence of Balamuthia mandrillaris, the Causative Agent of Amoebic Encephalitis Detering, H.; Aebischer, Toni; Dabrowski, Piotr Wojtek; Radonić, Aleksandar; Nitsche, Andreas; Renard, Bernhard Y.; Kiderlen, AlbrechtThe free-living amoeba Balamuthia mandrillaris is a rare but highly lethal agent of amoebic encephalitis in humans and many other mammalian species. Here, we announce the first draft genome sequence of the original 1990 ...
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2022-12-21ZeitschriftenartikelGenetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia Saghuag, Christina S.; Gamlem, Astrid L.; Hauge, Kirsti B.; Vahokoski, Juha; Klotz, Christian; Langeland, Nina; Hanevik, Kurt; Aebischer, ToniThe effectiveness of metronidazole against the tetraploid intestinal parasite Giardia lamblia is dependent on its activation/inactivation within the cytoplasm. There are several activating enzymes, including pyruvate ...
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2020-12-18ZeitschriftenartikelGenetic Diversity of the Flavohemoprotein Gene of Giardia lamblia: Evidence for High Allelic Heterozygosity and Copy Number Variation Saghaug, C. S.; Klotz, Christian; Kallio, J. P.; Aebischer, Toni; Langeland, N.; Hanevik, K.Purpose: The flavohemoprotein (gFlHb) in Giardia plays an important role in managing nitrosative and oxidative stress, and potentially also in virulence and nitroimidazole drug tolerance. The aim of this study was to analyze ...
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2012-03-23ZeitschriftenartikelGenetic Evidence of Functional Ficolin-2 Haplotype as Susceptibility Factor in Cutaneous Leishmaniasis Assaf, Amal; Hoang, Tong Van; Faik, Imad; Aebischer, Toni; Kremsner, Peter G.; Kun, Jürgen F. J.; Velavan, T. P.Background: Ficolin-2 coded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity. In this study, we analyzed five functional polymorphisms of the FCN2 gene for their possible association ...
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2019-05-10ZeitschriftenartikelGenetic variation in metronidazole metabolism and oxidative stress pathways in clinical Giardia lamblia assemblage A and B isolates Saghaug, Christina S.; Klotz, Christian; Kallio, Juha P.; Brattbakk, Hans-Richard; Stokowy, Tomasz; Aebischer, Toni; Kursula, Inari; Langeland, Nina; Hanevik, KurtPurpose: Treatment-refractory Giardia cases have increased rapidly within the last decade. No markers of resistance nor a standardized susceptibility test have been established yet, but several enzymes and their pathways ...
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2013-04-15ZeitschriftenartikelGiardia duodenalis arginine deiminase modulates the phenotype and cytokine secretion of human dendritic cells by depletion of arginine and formation of ammonia Banik, Stefanie; Viveros, Pablo Renner; Seeber, Frank; Klotz, Christian; Ignatius, Ralf; Aebischer, ToniDepletion of arginine is a recognized strategy that pathogens use to evade immune effector mechanisms. Depletion depends on microbial enzymes such as arginases, which are considered virulence factors. The effect is mostly ...
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2017-09-26ZeitschriftenartikelGiardia's Epithelial Cell Interaction In Vitro: Mimicking Asymptomatic Infection? Kraft, Martin R.; Klotz, Christian; Bücker, Roland; Schulzke, Jörg-Dieter; Aebischer, ToniThe protozoan parasite Giardia duodenalis is responsible for more than 280 million cases of gastrointestinal complaints (“giardiasis”) every year, worldwide. Infections are acquired orally, mostly via uptake of cysts in ...
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2021-02-22ZeitschriftenartikelHarmonization of Protocols for Multi-Species Organoid Platforms to Study the Intestinal Biology of Toxoplasma gondii and Other Protozoan Infections Holthaus, David; Delgado-Betancourt, Estefanía; Aebischer, Toni; Seeber, Frank; Klotz, ChristianThe small intestinal epithelium is the primary route of infection for many protozoan parasites. Understanding the mechanisms of infection, however, has been hindered due to the lack of appropriate models that recapitulate ...
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2012-06-12ZeitschriftenartikelHigh Prevalence of Giardia duodenalis Assemblage B Infection and Association with Underweight in Rwandan Children Ignatius, Ralf; Gahutu, Jean Bosco; Klotz, Christian; Steininger, Christian; Shyirambere, Cyprien; Lyng, Michel; Musemakweri, Andre; Aebischer, Toni; Martus, Peter; Harms, Gundel; Mockenhaupt, Frank P.Background: Giardia duodenalis is highly endemic in East Africa but its effects on child health, particularly of submicroscopic infections, i.e., those below the threshold of microscopy, and of genetic subgroups ...
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2013-08-19ZeitschriftenartikelHigh Sensitivity of Giardia duodenalis to Tetrahydrolipstatin (Orlistat) In Vitro Hahn, Juliane; Seeber, Frank; Kolodziej, Herbert; Ignatius, Ralf; Laue, Michael; Aebischer, Toni; Klotz, ChristianGiardiasis, a gastrointestinal disease caused by Giardia duodenalis, is currently treated mainly with nitroimidazoles, primarily metronidazole (MTZ). Treatment failure rates of up to 20 percent reflect the compelling need ...
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2013-11-04ZeitschriftenartikelIncreased expression of CD25, CD83, and CD86, and secretion of IL-12, IL-23, and IL-10 by human dendritic cells incubated in the presence of Toll-like receptor 2 ligands and Giardia duodenalis Obendorf, Janine; Viveros, Pablo Renner; Fehlings, Michael; Klotz, Christian; Aebischer, Toni; Ignatius, RalfBackground: Effects of Giardia duodenalis on dendritic cell (DC) functions may contribute to the pathogenesis of chronic giardiasis. G. duodenalis lysate has been shown to inhibit the activation of murine DCs through ...