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Auflistung Artikel in Fachzeitschriften nach Autor "Lewin, Astrid"
Anzeige der Publikationen 1-20 von 24
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2019-02-07ZeitschriftenartikelAnalysis of long non-coding RNA and mRNA expression in bovine macrophages brings up novel aspects of Mycobacterium avium subspecies paratuberculosis infections Gupta, Pooja; Peter, Sarah; Jung, Markus; Lewin, Astrid; Hemmrich-Stanisak, Georg; Franke, Andre; von Kleist, Max; Schütte, Christof; Einspanier, Ralf; Sharbati, Soroush; zur Bruegge, JenniferParatuberculosis is a major disease in cattle that severely affects animal welfare and causes huge economic losses worldwide. Development of alternative diagnostic methods is of urgent need to control the disease. Recent ...
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2023-06-01ZeitschriftenartikelAuswirkungen des Klimawandels auf wasserbürtige Infektionen und Intoxikationen Dupke, Susann; Buchholz, Udo; Fastner, Jutta; Förster, Christina; Frank, Christina; Lewin, Astrid; Rickerts, Volker; Selinka, Hans-Christoph
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2025-11-13ZeitschriftenartikelBiofilm formation by the global outbreak strain of Mycobacterium chimaera results in significantly reduced efficacy of standard disinfectants Oschmann, Anna Maria; Konrat, Katharina; Schaudinn, Christoph; Sohl, Genevieve; Wagner, Dirk; Lewin, Astrid; Arvand, MardjanBackground: In 2013, a global outbreak of Mycobacterium chimaera infections due to contaminated heater-cooler units emerged. This ongoing problem has highlighted the question of whether disinfection recommendations for ...
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2009-02-09ZeitschriftenartikelCharacterisation of porin genes from Mycobacterium fortuitum and their impact on growth Sharbati, Soroush; Schramm, Kira; Rempel, Sonja; Wang, Hwa; Andrich, Ronny; Tykiel, Verena; Kunisch, Ralph; Lewin, AstridBackground: Highly pathogenic mycobacteria like Mycobacterium tuberculosis are characterised by their slow growth and their ability to reside and multiply in the very hostile phagosomal environment and a correlation ...
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2024-07-09ZeitschriftenartikelClinical and genomic features of Mycobacterium avium complex: a multi-national European study Wetzstein, Nils; Diricks, Margo; Anton, Thomas B.; Andres, Sönke; Kuhns, Martin; Kohl, Thomas A.; Schwarz, Carsten; Lewin, Astrid; Kehrmann, Jan; Kahl, Barbara C.; Schmidt, Annika; Zimmermann, Stefan; Jansson, Moritz K.; Baron, Sophie A.; Schulthess, Bettina; Hogardt, Michael; Friesen, Inna; Niemann, Stefan; Wichelhaus, Thomas A.Background: The Mycobacterium avium complex (MAC) comprises the most frequent non-tuberculous mycobacteria (NTM) in Central Europe and currently includes twelve species. M. avium (MAV), M. intracellulare subsp. ...
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2020-04-21ZeitschriftenartikelCritical Role of Zur and SmtB in Zinc Homeostasis of Mycobacterium smegmatis Goethe, Elke; Laarmann, Kristin; Lührs, Janita; Jarek, Michael; Meens, Jochen; Lewin, Astrid; Goethe, RalphZinc homeostasis is crucial for bacterial cells, since imbalances affect viability. However, in mycobacteria, knowledge of zinc metabolism is incomplete. Mycobacterium smegmatis (MSMEG) is an environmental, nonpathogenic ...
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2005-11-08ZeitschriftenartikelDas langsame Wachstum von Mykobakterien - Mögliche Ursachen und Bedeutung für die Pathogenität Lewin, Astrid; Sharbati-Tehrani, SoroushDie Gattung Mycobacterium weist als charakteristische Eigenschaft lange sowie bei verschiedenen Spezies der Gattung stark voneinander abweichende Generationszeiten auf. Alle hochpathogenen Spezies wie der Tuberkuloseerreger ...
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2008-12-03ZeitschriftenartikelDetection of Balamuthia mandrillaris DNA by real-time PCR targeting the RNase P gene Kiderlen, Albrecht; Radam, Elke; Lewin, AstridBackground: The free-living amoeba Balamuthia mandrillaris may cause fatal encephalitis both in immunocompromised and in – apparently – immunocompetent humans and other mammalian species. Rapid, specific, sensitive, and ...
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2013-06-29ZeitschriftenartikelDormancy Associated Translation Inhibitor (DATIN/Rv0079) of Mycobacterium tuberculosis interacts with TLR2 and induces proinflammatory cytokine expression Kumar, Ashutosh; Lewin, Astrid; Rani, Pittu Sandhya; Qureshi, Insaf A.; Devi, Savita; Majid, Mohammad; Kamal, Elisabeth; Marek, Stefanie; Hasnain, Seyed E.; Ahmed, NiyazMycobacterium tuberculosis, the cause of tuberculosis in humans, is present approximately in one third of the world’s population, mostly in a dormant state. The proteins encoded by the dormancy survival regulon (DosR ...
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2024-03-27ZeitschriftenartikelGene knock-out in Mycobacterium abscessus using Streptococcus thermophilus CRISPR/Cas Akter, Suriya; Kamal, Elisabeth; Schwarz, Carsten; Lewin, AstridThe CRISPRi system using dCas9Sth1 from Streptococcus thermophilus developed for Mycobacterium tuberculosis and M. smegmatis was modified to allow gene knock-out in M. abscessus. Efficacy of the knock-out system was evaluated ...
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2021-09-21ZeitschriftenartikelGenetic diversification of persistent Mycobacterium abscessus within cystic fibrosis patients Lewin, Astrid; Kamal, Elisabeth; Semmler, Torsten; Winter, Katja; Kaiser, Sandra; Schäfer, Hubert; Mao, Lei; Eschenhagen, Patience; Grehn, Claudia; Bender, Jennifer; Schwarz, CarstenMycobacterium (M.) abscessus infections in Cystic Fibrosis (CF) patients cause a deterioration of lung function. Treatment of these multidrug-resistant pathogens is associated with severe side-effects, while frequently ...
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2012-09-11ZeitschriftenartikelIllegitimate recombination: An efficient method for random mutagenesis in Mycobacterium avium subsp. hominissuis Khattak, Faisal A.; Kumar, Ashutosh; Kamal, Elisabeth; Kunisch, Ralph; Lewin, AstridBackground: The genus Mycobacterium (M.) comprises highly pathogenic bacteria such as M. tuberculosis as well as environmental opportunistic bacteria called non-tuberculous mycobacteria (NTM). While the incidence of ...
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2023-06-01ZeitschriftenartikelImpact of climate change on waterborne infections and intoxications Dupke, Susann; Buchholz, Udo; Fastner, Jutta; Förster, Christina; Frank, Christina; Lewin, Astrid; Rickerts, Volker; Selinka, Hans-Christoph
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2024-01-20ZeitschriftenartikelImpact of Mycobacteroides abscessus colony morphology on biofilm formation and antimicrobial resistance Oschmann-Kadenbach, Anna Maria; Schaudinn, Claudia; Borst, Leonard; Schwarz, Carsten; Konrat, Katharina; Arvand, Mardjan; Lewin, AstridMycobacteroides abscessus is one of the most resistant bacteria so far known and causes severe and hard to treat lung infections in predisposed patients such as those with Cystic Fibrosis (CF). Further, it causes nosocomial ...
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2011-05-24ZeitschriftenartikelIntegrated MicroRNA-mRNA-Analysis of Human Monocyte Derived Macrophages upon Mycobacterium avium subsp. hominissuis Infection Sharbati, Jutta; Lewin, Astrid; Kutz-Lohroff, Barbara; Kamal, Elisabeth; Einspanier, Ralf; Sharbati, SoroushBackground: Many efforts have been made to understand basal mechanisms of mycobacterial infections. Macrophages are the first line of host immune defence to encounter and eradicate mycobacteria. Pathogenic species have ...
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2018-04-03ZeitschriftenartikelMALDI Spectra Database for Rapid Discrimination and Subtyping of Mycobacterium kansasii Murugaiyan, Jayaseelan; Lewin, Astrid; Kamal, Elisabeth; Bakuła, Zofia; Ingen, Jakko van; Ulmann, Vit; Barañano, Miren J. Unzaga; Humięcka, Joanna; Safianowska, Aleksandra; Roesler, Uwe H.; Jagielski, TomaszMycobacterium kansasii is an emerging non-tuberculous mycobacterial (NTM) pathogen capable of causing severe lung disease. Of the seven currently recognized M. kansasii genotypes (I-VII), genotypes I and II are most prevalent ...
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2017-01-03ZeitschriftenartikelMetabolic phenotype of clinical and environmental Mycobacterium avium subsp. hominissuis isolates Sanchini, Andrea; Dematheis, Flavia; Semmler, Torsten; Lewin, AstridBackground: Mycobacterium avium subsp. hominissuis (MAH) is an emerging opportunistic human pathogen. It can cause pulmonary infections, lymphadenitis and disseminated infections in immuno-compromised patients. In ...
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2022-08-08ZeitschriftenartikelMolecular Epidemiology of Mycobacterium abscessus Isolates Recovered from German Cystic Fibrosis Patients Wetzstein, Nils; Diricks, Margo; Kohl, Thomas A.; Wichelhaus, Thomas A.; Andres, Sönke; Paulowski, Laura; Schwarz, Carsten; Lewin, Astrid; Kehrmann, Jan; Kahl, Barbara C.; Dichtl, Karl; Hügel, Christian; Eickmeier, Olaf; Smaczny, Christina; Schmidt, Annika; Zimmermann, Stefan; Nährlich, Lutz; Hafkemeyer, Sylvia; Niemann, Stefan; Maurer, Florian P.; Hogardt, MichaelInfections due to Mycobacterium abscessus are a major cause of mortality and morbidity in cystic fibrosis (CF) patients. Furthermore, M. abscessus has been suspected to be involved in person-to-person transmissions. In ...
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2020-01-29ZeitschriftenartikelMutation on lysX from Mycobacterium avium hominissuis impacts the host–pathogen interaction and virulence phenotype Kirubakar, Greana; Schäfer, Hubert; Rickerts, Volker; Schwarz, Carsten; Lewin, AstridThe lysX gene from Mycobacterium avium hominissuis (MAH) is not only involved in cationic antimicrobial resistance but also regulates metabolic activity. An MAH lysX deficient mutant was shown to exhibit a metabolic shift ...
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2012-06-13ZeitschriftenartikelMycobacterium tuberculosis DosR Regulon Gene Rv0079 Encodes a Putative, ‘Dormancy Associated Translation Inhibitor (DATIN)’ Kumar, Ashutosh; Majid, Mohammad; Kunisch, Ralph; Rani, Pittu Sandhya; Qureshi, Insaf A.; Lewin, Astrid; Hasnain, Seyed E.; Ahmed, NiyazMycobacterium tuberculosis is a major human pathogen that has evolved survival mechanisms to persist in an immune-competent host under a dormant condition. The regulation of M. tuberculosis metabolism during latent infection ...