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Auflistung Artikel in Fachzeitschriften nach Autor "Mahrhold, Stefan"
Anzeige der Publikationen 1-6 von 6
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2018-05-02ZeitschriftenartikelA lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency Stern, Daniel; Weisemann, Jasmin; Le Blanc, Alexander; von Berg, Laura; Mahrhold, Stefan; Piesker, Janett; Laue, Michael; Luppa, Peter B.; Dorner, Martin B.; Dorner, Brigitte G.; Rummel, AndreasThe exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of synaptic vesicle proteins embedded in the presynaptic membrane. ...
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2016-05-17ZeitschriftenartikelBotulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin Weisemann, Jasmin; Stern, Daniel; Mahrhold, Stefan; Dorner, Brigitte; Rummel, AndreasBotulinum neurotoxins (BoNTs) exhibit extraordinary potency due to their exquisite neurospecificity, which is achieved by dual binding to complex polysialo-gangliosides and synaptic vesicle proteins. The luminal domain 4 ...
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2019-04-02ZeitschriftenartikelFunctional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology von Berg, Laura; Stern, Daniel; Pauly, Diana; Mahrhold, Stefan; Weisemann, Jasmin; Jentsch, Lisa; Hansbauer, Eva-Maria; Müller, Christian; Avondet, Marc A.; Rummel, Andreas; Dorner, Martin B.; Dorner, Brigitte G.Botulinum neurotoxins (BoNTs) are the most potent toxins known and cause the life threatening disease botulism. Sensitive and broad detection is extremely challenging due to the toxins’ high potency and molecular heterogeneity ...
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2021-04-08ZeitschriftenartikelInnovative and Highly Sensitive Detection of Clostridium perfringens Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies Neumann, Thea; Krüger, Maren; Weisemann, Jasmin; Mahrhold, Stefan; Stern, Daniel; Dorner, Martin B.; Feraudet-Tarisse, Cécile; Pöhlmann, Christopher; Schulz, Katharina; Messelhäußer, Ute; Rimek, Dagmar; Gessler, Frank; Elßner, Thomas; Simon, Stéphanie; Rummel, Andreas; Dorner, Brigitte G.Clostridium perfringens enterotoxin (CPE) regularly causes food poisoning and antibioticassociated diarrhea; therefore, reliable toxin detection is crucial. To this aim, we explored stationary and mobile strategies to ...
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2016-06-13ZeitschriftenartikelN-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A Yao, Guorui; Zhang, Sicai; Mahrhold, Stefan; Lam, Kwok-ho; Stern, Daniel; Bagramyan, Karine; Perry, Kay; Kalkum, Markus; Rummel, Andreas; Dong, Min; Jin, RongshengBotulinum neurotoxin serotype A1 (BoNT/A1), a licensed drug widely used for medical and cosmetic applications, exerts its action by invading motoneurons. Here we report a 2.0-Å-resolution crystal structure of the BoNT/A1 ...
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2016-06-16ZeitschriftenartikelOnly the complex N559-glycan in SV2C mediates high affinity binding to botulinum neurotoxin serotype A1 Mahrhold, Stefan; Bergström, Tomas; Stern, Daniel; Dorner, Brigitte; Astot, Crister; Rummel, AndreasThe extraordinary potency of botulinum neurotoxins (BoNTs) is mediated by their high neurospecificity, targeting peripheral cholinergic motoneurons leading to flaccid paralysis and successive respiratory failure. Complex ...