Browsing Artikel in Fachzeitschriften by Author "Damaso, Clarissa R."

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2018-07-26Zeitschriftenartikel

Beyond the myths: Novel findings for old paradigms in the history of the smallpox vaccine

Esparza, José; Nitsche, Andreas; Damaso, Clarissa R.

The discovery of smallpox vaccination by Edward Jenner in 1796 gave a new perspective to science in the struggle against this devastating disease. Smallpox has claimed hundreds of millions of lives over the centuries. ...
2020-06-03Zeitschriftenartikel

Early smallpox vaccine manufacturing in the United States: Introduction of the “animal vaccine” in 1870, establishment of “vaccine farms”, and the beginnings of the vaccine industry

Esparza, José; Lederman, Seth; Nitsche, Andreas; Damaso, Clarissa R.

For the first 80–90 years after Jenner’s discovery of vaccination in 1796, the main strategy used to disseminate and maintain the smallpox vaccine was arm-to-arm vaccination, also known as Jennerian or humanized vaccination. ...
2017-11-11Zeitschriftenartikel

Equination (inoculation of horsepox): An early alternative to vaccination (inoculation of cowpox) and the potential role of horsepox virus in the origin of the smallpox vaccine

Esparza, José; Schrick, Livia; Damaso, Clarissa R.; Nitsche, Andreas

For almost 150 years after Edward Jenner had published the “Inquiry” in 1798, it was generally assumed that the cowpox virus was the vaccine against smallpox. It was not until 1939 when it was shown that vaccinia, the ...
2023-09-20Zeitschriftenartikel

Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox vaccines

Souza, Aline R. V.; Brinkmann, Annika; Esparza, José; Nitsche, Andreas; Damaso, Clarissa R.

Vaccinia virus is the active component of all modern smallpox vaccines after the mid-20th century, but it is uncertain to what extent cowpox, vaccinia, and horsepox viruses were used to produce vaccines before then. Genome ...
2020-12-04Zeitschriftenartikel

Re-assembly of nineteenth-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the USA

Brinkmann, Annika; Souza, Aline R. V.; Esparza, José; Nitsche, Andreas; Damaso, Clarissa R.

According to a recent article published in Genome Biology, Duggan and coworkers sequenced and partially assembled five genomes of smallpox vaccines from the nineteenth century. No information regarding the ends of genomes ...