Browsing Artikel in Fachzeitschriften by Author "Spengler, Jessica R."
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2021-01-25ZeitschriftenartikelAsymptomatic Infection of Marburg Virus Reservoir Bats Is Explained by a Strategy of Immunoprotective Disease Tolerance Guito, Jonathan C.; Prescott, Joseph B.; Arnold, Catherine E.; Amman, Brian R.; Schuh, Amy J.; Spengler, Jessica R.; Sealy, Tara K.; Harmon, Jessica R.; Coleman-McCray, JoAnn D.; Kulcsar, Kirsten A.; Nagle, Elyse R.; Kumar, Raina; Palacios, Gustavo; Sanchez-Lockhart, Mariano; Towner, Jonathan S.Marburg virus (MARV) is among the most virulent pathogens of primates, including humans. Contributors to severe MARV disease include immune response suppression and inflammatory gene dysregulation (“cytokine storm”), leading ...
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2019-12-04ZeitschriftenartikelRousette Bat Dendritic Cells Overcome Marburg Virus-Mediated Antiviral Responses by Upregulation of Interferon-Related Genes While Downregulating Proinflammatory Disease Mediators Prescott, Joseph; Guito, Jonathan C.; Spengler, Jessica R.; Arnold, Catherine E.; Schuh, Amy J.; Amman, Brian R.; Sealy, Tara K.; Guerrero, Lisa W.; Palacios, Gustavo F.; Sanchez-Lockhart, Mariano; Albariño, Cesar G.; Towner, Jonathan S.Dysregulated and maladaptive immune responses are at the forefront of human diseases caused by infection with zoonotic viral hemorrhagic fever viruses. Elucidating mechanisms of how the natural animal reservoirs of these ...
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2020-02-22ZeitschriftenartikelThe Utility of Human Immune System Mice for High-Containment Viral Hemorrhagic Fever Research Wozniak, David Maximilian; Lavender, Kerry J.; Prescott, Joseph; Spengler, Jessica R.Human immune system (HIS) mice are a subset of humanized mice that are generated by xenoengraftment of human immune cells or tissues and/or their progenitors into immunodeficient mice. Viral hemorrhagic fevers (VHFs) cause ...