Browsing Artikel in Fachzeitschriften by Author "Dorner, Brigitte G."
Now showing items 1-16 of 16
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2023-12-09ZeitschriftenartikelA bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity Stern, Daniel; Meyer, Tanja C.; Treindl, Fridolin; Mages, Hans Werner; Krüger, Maren; Skiba, Martin; Krüger, Jan Philipp; Zobel, Christian M.; Schreiner, Maximilian; Grossegesse, Marica; Rinner, Thomas; Peine, Caroline; Stoliaroff-Pépin, Anna; Harder, Thomas; Hofmann, Natalie; Michel, Janine; Nitsche, Andreas; Stahlberg, Silke; Kneuer, Antje; Sandoni, Anna; Kubisch, Ulrike; Schlaud, Martin; Mankertz, Annette; Schwarz, Tatjana; Corman, Victor M.; Müller, Marcel A.; Drosten, Christian; de la Rosa, Kathrin; Schaade, Lars; Dorner, Martin B.; Dorner, Brigitte G.Serological assays measuring antibodies against SARS-CoV-2 are key to describe the epidemiology, pathobiology or induction of immunity after infection or vaccination. Of those, multiplex assays targeting multiple antigens ...
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2018-05-02ZeitschriftenartikelA lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency Stern, Daniel; Weisemann, Jasmin; Le Blanc, Alexander; von Berg, Laura; Mahrhold, Stefan; Piesker, Janett; Laue, Michael; Luppa, Peter B.; Dorner, Martin B.; Dorner, Brigitte G.; Rummel, AndreasThe exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of synaptic vesicle proteins embedded in the presynaptic membrane. ...
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2018-08-01ZeitschriftenartikelBotulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58–K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities Sikorra, Stefan; Skiba, Martin; Dorner, Martin B.; Weisemann, Jasmin; Weil, Mirjam; Valdezate, Sylvia; Davletov, Bazbek; Rummel, Andreas; Dorner, Brigitte G.; Binz, ThomasIn the recent past, about 40 botulinum neurotoxin (BoNT) subtypes belonging to serotypes A, B, E, and F pathogenic to humans were identified among hundreds of independent isolates. BoNTs are the etiological factors of ...
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2022-02-02ZeitschriftenartikelConstruction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid Nowakowska, Maria B.; Selby, Katja; Przykopanski, Adina; Krüger, Maren; Krez, Nadja; Dorner, Brigitte G.; Dorner, Martin B.; Jin, Rongsheng; Minton, Nigel P.; Rummel, Andreas; Lindström, MiiaBotulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium botulinum, cause botulism, a rare but fatal illness affecting humans and animals. Despite causing a life-threatening disease, BoNT is a ...
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2023-01-18ZeitschriftenartikelCrystal structures of OrfX1, OrfX2 and the OrfX1–OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1 Gao, Linfeng; Lam, Kwok-ho; Liu, Shun; Przykopanski, Adina; Lübke, Johanna; Qi, Ruifeng; Krüger, Maren; Nowakowska, Maria B.; Selby, Katja; Douillard, François P.; Dorner, Martin B.; Perry, Kay; Linström, Miia; Dorner, Brigitte G.; Rummel, Andreas; Jin, RongshengBotulinum neurotoxins (BoNTs) are among the most lethal toxins known to humans, comprising seven established serotypes termed BoNT/A–G encoded in two types of gene clusters (ha and orfX) in BoNT-producing clostridia. The ...
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2021-01-13ZeitschriftenartikelDevelopment and Evaluation of an Immuno-MALDI-TOF Mass Spectrometry Approach for Quantification of the Abrin Toxin in Complex Food Matrices Livet, Sandrine; Worbs, Sylvia; Volland, Hervé; Simon, Stéphanie; Dorner, Martin B.; Fenaille, François; Dorner, Brigitte G.; Becher, FrançoisThe toxin abrin found in the seeds of Abrus precatorius has attracted much attention regarding criminal and terroristic misuse over the past decade. Progress in analytical methods for a rapid and unambiguous identification ...
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2021-04-18ZeitschriftenartikelDifferentiation, Quantification and Identification of Abrin and Abrus precatorius Agglutinin Worbs, Sylvia; Kampa, Bettina; Skiba, Martin; Hansbauer, Eva-Maria; Stern, Daniel; Volland, Hervé; Becher, François; Simon, Stéphanie; Dorner, Martin B.; Dorner, Brigitte G.Abrin, the toxic lectin from the rosary pea plant Abrus precatorius, has gained considerable interest in the recent past due to its potential malevolent use. However, reliable and easy-to-use assays for the detection and ...
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2019-04-02ZeitschriftenartikelFunctional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology von Berg, Laura; Stern, Daniel; Pauly, Diana; Mahrhold, Stefan; Weisemann, Jasmin; Jentsch, Lisa; Hansbauer, Eva-Maria; Müller, Christian; Avondet, Marc A.; Rummel, Andreas; Dorner, Martin B.; Dorner, Brigitte G.Botulinum neurotoxins (BoNTs) are the most potent toxins known and cause the life threatening disease botulism. Sensitive and broad detection is extremely challenging due to the toxins’ high potency and molecular heterogeneity ...
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2022-05-02ZeitschriftenartikelGenomic and Phenotypic Characterization of Clostridium botulinum Isolates from an Infant Botulism Case Suggests Adaptation Signatures to the Gut Douillard, François P.; Derman, Yağmur; Woudstra, Cédric; Selby, Karja; Maklin, Tommi; Dorner, Martin B.; Saxén, Harri; Dorner, Brigitte G.; Korkeala, Hannu; Lindström, MiiaIn early life, the immature human gut microbiota is prone to colonization by pathogens that are usually outcompeted by mature microbiota in the adult gut. Colonization and neurotoxin production by a vegetative Clostridium ...
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2021-04-08ZeitschriftenartikelInnovative and Highly Sensitive Detection of Clostridium perfringens Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies Neumann, Thea; Krüger, Maren; Weisemann, Jasmin; Mahrhold, Stefan; Stern, Daniel; Dorner, Martin B.; Feraudet-Tarisse, Cécile; Pöhlmann, Christopher; Schulz, Katharina; Messelhäußer, Ute; Rimek, Dagmar; Gessler, Frank; Elßner, Thomas; Simon, Stéphanie; Rummel, Andreas; Dorner, Brigitte G.Clostridium perfringens enterotoxin (CPE) regularly causes food poisoning and antibioticassociated diarrhea; therefore, reliable toxin detection is crucial. To this aim, we explored stationary and mobile strategies to ...
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2022-04-14ZeitschriftenartikelMALDI-TOF-MS-Based Identification of Monoclonal Murine Anti-SARS-CoV-2 Antibodies within One Hour Tscheuschner, Georg; Kaiser, Melanie N.; Lisec, Jan; Beslic, Denis; Muth, Thilo; Krüger, Maren; Mages, Hans Werner; Dorner, Brigitte G.; Knospe, Julia; Schenk, Jörg A.; Sellrie, Frank; Weller, Michael G.During the SARS-CoV-2 pandemic, many virus-binding monoclonal antibodies have been developed for clinical and diagnostic purposes. This underlines the importance of antibodies as universal bioanalytical reagents. However, ...
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2021-12-20ZeitschriftenartikelPreclinical evaluation of a candidate naked plasmid DNA vaccine against SARS-CoV-2 Lassaunière, Ria; Polacel, Charlotta; Gram, Gregers J.; Frische, Anders; Tingstedt, Jeanette Linnea; Krüger, Maren; Dorner, Brigitte G.; Cook, Anthony; Brown, Renita; Orekov, Tatyana; Putmon-Taylor, Tammy; Campbell, Tracey-Ann; Greenhouse, Jack; Pessaint, Laurent; Andersen, Hanne; Lewis, Mark G.; Fomsgaard, AndersNew generation plasmid DNA vaccines may be a safe, fast and simple emergency vaccine platform for preparedness against emerging viral pathogens. Applying platform optimization strategies, we tested the pre-clinical ...
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2018-06-26ZeitschriftenartikelReplacing the mouse bioassay for diagnostics and potency testing of botulinum neurotoxins – progress and challenges Stern, Daniel; von Berg, Laura; Skiba, Martin; Dorner, Martin B.; Dorner, Brigitte G.Botulinum neurotoxins (BoNTs) are the most potent toxins known and the causative agents of the rare but potentially life-threatening disease botulism. The elaborate mode of action of BoNTs at the molecular level, their ...
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2021-01-29ZeitschriftenartikelRicin Antibodies’ Neutralizing Capacity against Different Ricin Isoforms and Cultivars Orsini Delgado, Maria Lucia; Avril, Arnaud; Prigent, Julie; Dano, Julie; Rouaix, Audrey; Worbs, Sylvia; Dorner, Brigitte G.; Rougeaux, Clémence; Becher, François; Fenaille, François; Livet, Sandrine; Volland, Hervé; Tournier, Jean-Nicolas; Simon, StéphanieRicin, a highly toxic protein from Ricinus communis, is considered a potential biowarfare agent. Despite the many data available, no specific treatment has yet been approved. Due to their ability to provide immediate ...
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2021-05-25ZeitschriftenartikelStrengthening the United Nations Secretary-General’s Mechanism to an alleged use of bioweapons through a quality-assured laboratory response Appelt, Sandra; Rohleder, Anna-Maria; Ivernizzi, Cédric; Mikulak, Robert; Brinkmann, Annika; Nitsche, Andreas; Krüger, Maren; Dorner, Martin B.; Dorner, Brigitte G.; Scholz, Holger C.; Grunow, RolandThe cascade of innovations in biotechnology opens new pathways for biological warfare. The international laboratory network being developed under the UN Secretary-General’s Mechanism could provide vital evidence in case ...
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2023-03-13ZeitschriftenartikelVaccine effectiveness against severe COVID-19 during the Omicron wave in Germany: results from the COViK study Stoliaroff-Pepin, Anna; Peine, Caroline; Herath, Tim; Lachmann, Johannes; Hellenbrand, Wiebke; Perriat, Delphine; Dörre, Andreas; Michel, Janine; Grossegesse, Marica; Hofmann, Natalie; Rinner, Thomas; Kohl, Claudia; Brinkmann, Annika; Meyer, Tanja; Stern, Daniel; Treindl, Fridolin; Dorner, Brigitte G.; Hein, Sascha; Werel, Laura; Hildt, Eberhard; Gläser, Sven; Schühlen, Helmut; Isner, Caroline; Peric, Alexander; Ghouzi, Ammar; Reichardt, Annette; Janneck, Matthias; Lock, Guntram; Huster, Dominik; Grünewald, Thomas; Schaade, Lars; Wichmann, Ole; Harder, ThomasPurpose: COViK, a prospective hospital-based multicenter case-control study in Germany, aims to assess the effectiveness of COVID-19 vaccines against severe disease. Here, we report vaccine effectiveness (VE) against ...