Browsing Artikel in Fachzeitschriften by Author "Hölzer, Martin"
Now showing items 1-20 of 22
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2020-10-08ZeitschriftenartikelA decade of de novo transcriptome assembly: Are we there yet? Hölzer, MartinA decade ago, de novo transcriptome assembly evolved as a versatile and powerful approach to make evolutionary assumptions, analyse gene expression, and annotate novel transcripts, in particular, for non‐model organisms ...
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2020-10-08ZeitschriftenartikelA decade of de novo transcriptome assembly: Are we there yet? Hölzer, MartinA decade ago, de novo transcriptome assembly evolved as a versatile and power- ful approach to make evolutionary assumptions, analyse gene expression, and anno- tate novel transcripts, in particular, for non-model organisms ...
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2022-08-15ZeitschriftenartikelAdvancing Precision Vaccinology by Molecular and Genomic Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 in Germany, 2021 Oh, Djin-Ye; Hölzer, Martin; Paraskevopolou, Sofia; Tofimova, Maria; Hartkopf, Felix; Budt, Matthias; Wedde, Marianne; Richard, Hugues; Haldemann, Berit; Domaszewska, Teresa; Reiche, Janine; Keeren, Kathrin; Radonić, Aleksander; Ramos Calderón, Julia Patricia; Smith, Maureen Rebecca; Brinkmann, Annika; Trappe, Kathrin; Drechsel, Oliver; Klaper, Kathleen; Hein, Sascha; Hildt, Eberhardt; Haas, Walter; Calvignac-Spencer, Sébastien; Semmler, Torsten; Dürrwald, Ralf; Thürmer, Andrea; Drosten, Christian; Fuchs, Stephan; Kröger, Stefan; von Kleist, Max; Wolff, Thorsten; Integrated Molecular Surveillance for SARS-CoV-2 (IMS-SC2) Laboratory NetworkBackground Comprehensive pathogen genomic surveillance represents a powerful tool to complement and advance precision vaccinology. The emergence of the Alpha variant in December 2020 and the resulting efforts to track ...
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2022-03-03ZeitschriftenartikelAntibody escape and global spread of SARS-CoV-2 lineage A.27 Kaleta, Tamara; Kern, Lisa; Hong, Samuel Leandro; Hölzer, Martin; Kochs, Georg; Beer, Julius; Schnepf, Daniel; Schwemmle, Martin; Bollen, Nena; Kolb, Philipp; Huber, Magdalena; Ulferts, Svenja; Weigang, Sebastian; Dudas, Gytis; Alice, Wittig; Jaki, Lena; Padane, Abdou; Lagare, Adamou; Salou, Mounerou; Ozer, Egon Anderson; Nnaemeka, Ndodo; Odoom, John Kofi; Rutayisire, Robert; Benkahla, Alia; Akoua-Koffi, Chantal; Ouedraogo, Abdoul-Salam; Simon-Lorière, Etienne; Enouf, Vincent; Kröger, Stefan; Calvignac-Spencer, Sébastien; Baele, Guy; Panning, Marcus; Fuchs, JonasIn spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 ...
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2022-06-28ZeitschriftenartikelBAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors Sevdali, Eirini; Block, Violeta; Lataretu, Marie; Li, Huiying; Smulski, Christian R.; Briem, Jana-Susann; Heitz, Yannic; Fischer, Beate; Ramirez, Neftali-Jose; Grimbacher, Bodo; Jäck, Hans-Martin; Voll, Reinhard E.; Hölzer, Martin; Schneider, Pascal; Eibel, HermannBinding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the same levels of BAFFR, but only memory ...
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2022-07-14ZeitschriftenartikelComparative transcriptomics identifies candidate genes involved in the evolutionary transition from dehiscent to indehiscent fruits in Lepidium (Brassicaceae) Gramzow, Lydia; Klupsch, Katharina; Fernández-Pozo, Noé; Hölzer, Martin; Marz, Manja; Rensing, Stefan A.; Theißen, GünterBackground Fruits are the seed-bearing structures of flowering plants and are highly diverse in terms of morphology, texture and maturation. Dehiscent fruits split open upon maturation to discharge their seeds while ...
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2021-05-12ZeitschriftenartikelComparison of Illumina and Oxford Nanopore Technology for genome analysis of Francisella tularensis, Bacillus anthracis, and Brucella suis Linde, Jörg; Brangsch, Hanka; Hölzer, Martin; Thomas, Christine; Elschner, Mandy C.; Melzer, Falk; Tomaso, HerbertBackground Bacterial epidemiology needs to understand the spread and dissemination of strains in a One Health context. This is important for highly pathogenic bacteria such as Bacillus anthracis, Brucella species, and ...
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2020-11-04ZeitschriftenartikelComputational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research Hufsky, Franziska; Lamkiewicz, Kevin; Almeida, Alexandre; Aouacheria, Abdel; Arighi, Cecilia; Bateman, Alex; Baumbach, Jan; Beerenwinkel, Niko; Brandt, Christian; Cacciabue, Marco; Chuguransky, Sara; Drechsel, Oliver; Finn, Robert D; Fritz, Adrian; Fuchs, Stephan; Hattab, Georges; Hauschild, Anne-Christin; Heider, Dominik; Hoffmann, Marie; Hölzer, Martin; Hoops, Stefan; Kaderali, Lars; Kalvari, Ioanna; von Kleist, Max; Kmiecinski, Renó; Kühnert, Denise; Lasso, Gorka; Libin, Pieter; List, Markus; Löchel, Hannah F.; Martin, Maria J.; Martin, Roman; Matschinske, Julian; McHardy, Alice C.; Mendes, Pedro; Mistry, Jaina; Navratil, Vincent; Nawrocki, Eric P.; O'Toole, Áine Niamh; Ontiveros-Palacios, Nancy; Petrov, Anton I; Rangel-Pineros, Guillermo; Redaschi, Nicole; Reimering, Susanne; Reinert, Knut; Reyes, Alejandro; RIchardson, Lorna; Robertson, David L.; Sadegh, Sepideh; Singer, Joshua B.; Theys, Kristof; Upton, Chris; Welzel, Marius; Williams, Lowri; Marz, ManjaSARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of coronaviruses has been studied for many years. ...
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2021-12-16ZeitschriftenartikelContext-aware genomic surveillance reveals hidden transmission of a carbapenemase-producing Klebsiella pneumoniae Viehweger, Adrian; Blumenscheit, Christian; Lippmann, Norman; Wyres, Kelly L.; Brandt, Christian; Hans, Jörg B.; Hölzer, Martin; Irber, Luiz; Gatermann, Sören; Lübbert, Christoph; Pletz, Mathias W.; Holt, Kathryn E.; König, BrigitteGenomic surveillance can inform effective public health responses to pathogen outbreaks. However, integration of non-local data is rarely done. We investigate two large hospital outbreaks of a carbapenemase-carrying ...
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2022-03-14ZeitschriftenartikelCorrigendum: poreCov - An Easy to Use, Fast, and Robust Workflow for SARS CoV-2 Genome Reconstruction via Nanopore Sequencing Brandt, Christian; Krautwurst, Sebastian; Spott, Riccardo; Lohde, Mara; Jundzill, Mateusz; Marquet, Mike; Hölzer, Martin
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2022-02-16ZeitschriftenartikelEditorial: The Transition Era to New Sequencing Technologies and Their Application to Integrative Omics in Molecular Surveillance Hölzer, Martin; Escobar-Zepeda, Alejandra; Linde, Jörg; Horn, Fabian
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2022-01-04ZeitschriftenartikelInvestigation of a Limited but Explosive COVID-19 Outbreak in a German Secondary School Baumgarte, Sigrid; Hartkopf, Felix; Hölzer, Martin; von Kleist, Max; Neitz, Sabine; Kriegel, Martin; Bollongino, KirstenThe role of schools as a source of infection and driver in the coronavirus-pandemic has been controversial and is still not completely clarified. To prevent harm and disadvantages for children and adolescents, but also ...
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2023-01-04ZeitschriftenartikelNanopore-Based Enrichment of Antimicrobial Resistance Genes – A Case-Based Study Viehweger, Adrian; Marquet, Mike; Hölzer, Martin; Dietze, Nadine; Pletz, Mathias W.; Brandt, ChristianRapid screening of hospital admissions to detect asymptomatic carriers of resistant bacteria can prevent pathogen outbreaks. However, the resulting isolates rarely have their genome sequenced due to cost constraints and ...
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2022-03-22ZeitschriftenartikelNear Chromosome-Level Genome Assembly and Annotation of Rhodotorula babjevae Strains Reveals High Intraspecific Divergence Martín-Hernández, Giselle C.; Müller, Bettina; Brandt, Christian; Hölzer, Martin; Viehweger, Adrian; Passoth, VolkmarThe genus Rhodotorula includes basidiomycetous oleaginous yeast species. Rhodotorula babjevae can produce compounds of biotechnological interest such as lipids, carotenoids, and biosurfactants from low value substrates ...
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2021-07-28ZeitschriftenartikelporeCov-An Easy to Use, Fast, and Robust Workflow for SARS-CoV-2 Genome Reconstruction via Nanopore Sequencing Brandt, Christian; Krautwurst, Sebastian; Spott, Riccardo; Lohde, Mara; Jundzill, Mateusz; Marquet, Mike; Hölzer, MartinIn response to the SARS-CoV-2 pandemic, a highly increased sequencing effort has been established worldwide to track and trace ongoing viral evolution. Technologies, such as nanopore sequencing via the ARTIC protocol are ...
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2021-07-21ZeitschriftenartikelRise and Fall of SARS-CoV-2 Lineage A.27 in Germany Calvignac-Spencer, Sébastien; Budt, Matthias; Huska, Matthew; Richard, Hugues; Leipold, Luca; Grabenhenrich, Linus; Semmler, Torsten; von Kleist, Max; Kröger, Stefan; Wolff, Thorsten; Hölzer, MartinHere, we report on the increasing frequency of the SARS-CoV-2 lineage A.27 in Germany during the first months of 2021. Genomic surveillance identified 710 A.27 genomes in Germany as of 2 May 2021, with a vast majority ...
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2020-12-10ZeitschriftenartikelRNAflow: An Effective and Simple RNA-Seq Differential Gene Expression Pipeline Using Nextflow Lataretu, Marie; Hölzer, MartinRNA-Seq enables the identification and quantification of RNA molecules, often with the aim of detecting differentially expressed genes (DEGs). Although RNA-Seq evolved into a standard technique, there is no universal gold ...
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2020-12-10ZeitschriftenartikelRNAflow: An Effective and Simple RNA-Seq Differential Gene Expression Pipeline Using Nextflow Lataretu, Marie; Hölzer, MartinRNA-Seq enables the identification and quantification of RNA molecules, often with the aim of detecting differentially expressed genes (DEGs). Although RNA-Seq evolved into a standard technique, there is no universal gold ...
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2021-01-26ZeitschriftenartikelRUNX3 Transcript Variants Have Distinct Roles in Ovarian Carcinoma and Differently Influence Platinum Sensitivity and Angiogenesis Heinze, Karolin; Hölzer, Martin; Ungelenk, Martin; Gerth, Melanie; Thomale, Jürgen; Heller, Regine; Morden, Claire R.; McManus, Kirk J.; Mosig, Alexander S.; Dürst, Matthias; Runnebaum, Ingo B.; Häfner, NormanThe prognosis of late-stage epithelial ovarian cancer (EOC) patients is affected by chemotherapy response and the malignant potential of the tumor cells. In earlier work, we identified hypermethylation of the runt-related ...
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2021-03-05ZeitschriftenartikelSARS-CoV-2-Varianten: Evolution im Zeitraffer Oh, Djin-Ye; Kröger, Stefan; Wedde, Marianne; Hartkopf, Felix; Budt, Matthias; Seifried, Janna; Radonic, Aleksandar; Belarbi, Essia; Hölzer, Martin; Böttcher, Sindy; Schubert, Grit; Kaiser, Sandra; Sachse, Andreas; Drechsel, Oliver; Grajcar, Romina; Huska, Matthew; Lanxin, Zhan; Domaszewska, Teresa; Zhang, Lanxin; Brinkmann, Annika; Yahosseini, Kyanoush; Grabenhenrich, Linus; Hamouda, Osamah; Dürrwald, Ralf; Haas, Walter; Calvignac-Spencer, Sébastien; Semmler, Torsten; Schaade, Lars; Mielke, Martin; von Kleist, Max; Fuchs, Stephan; Wieler, Lothar H.; Wolff, ThorstenDas Betacoronavirus SARS-CoV-2 gelangte höchstwahrscheinlich als zoonotischer Erreger gegen Ende 2019 in die menschliche Bevölkerung, vermutlich in Form einer einzelnen Transmission (monophyletischer Ursprung) aus einem ...