Artikel in Fachzeitschriften: Neuzugänge
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2020-12-07ZeitschriftenartikelFLEXIQuant-LF to quantify protein modification extent in label-free proteomics data Improvements in LC-MS/MS methods and technology have enabled the identification of thousands of modified peptides in a single experiment. However, protein regulation by post-translational modifications (PTMs) is not binary, ...
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2020-11-28ZeitschriftenartikelA Multi-Omics Protocol for Swine Feces to Elucidate Longitudinal Dynamics in Microbiome Structure and Function Swine are regarded as promising biomedical models, but the dynamics of their gastrointestinal microbiome have been much less investigated than that of humans or mice. The aim of this study was to establish an integrated ...
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2020-04-04ZeitschriftenartikelInterventions to Increase the Reachability of Migrants in Germany With Health Interview Surveys: Mixed-Mode Feasibility Study Background: Germany is a popular destination for immigrants, and migration has increased in recent years. It is therefore important to collect reliable data on migrants’ health. The Robert Koch Institute, Berlin, Germany, ...
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2021-01-25ZeitschriftenartikelAsymptomatic Infection of Marburg Virus Reservoir Bats Is Explained by a Strategy of Immunoprotective Disease Tolerance Marburg virus (MARV) is among the most virulent pathogens of primates, including humans. Contributors to severe MARV disease include immune response suppression and inflammatory gene dysregulation (“cytokine storm”), leading ...
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2021-01-29ZeitschriftenartikelVertrauen der Bevölkerung in staatliche Institutionen im ersten Halbjahr der Coronapandemie: Erkenntnisse aus dem Projekt COVID-19 Snapshot Monitoring (COSMO) Hintergrund: In der Coronaviruspandemie nehmen 2 Institutionen eine zentrale Rolle in der evidenzbasierten Einordnung des Geschehens für Politik und Bevölkerung ein. Das Robert Koch-Institut (RKI) koordiniert die ...
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2020-11-25ZeitschriftenartikelSource attribution of community-acquired cases of Legionnaires’ disease–results from the German LeTriWa study Introduction Sources of infection of most cases of community-acquired Legionnaires’ disease (CALD) are unknown. Objective Identification of sources of infection of CALD. Setting Berlin; December 2016–May ...
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2020-11-20ZeitschriftenartikelIncreasing the willingness to participate in organ donation through humorous health communication: (Quasi-) experimental evidence Increasing people’s willingness to donate organs after their death requires effective communication strategies. In two preregistered studies, we assessed whether humorous entertainment education formats on organ donation ...
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2020-12-10ZeitschriftenartikelRNAflow: An Effective and Simple RNA-Seq Differential Gene Expression Pipeline Using Nextflow RNA-Seq enables the identification and quantification of RNA molecules, often with the aim of detecting differentially expressed genes (DEGs). Although RNA-Seq evolved into a standard technique, there is no universal gold ...
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2020-12-09ZeitschriftenartikelA Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition Background Antibiotic-resistant Klebsiella pneumoniae are a major cause of hospital- and community-acquired infections, including sepsis, liver abscess, and pneumonia, driven mainly by the emergence of successful high-risk ...
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2021-01-25ZeitschriftenartikelImpact of the COVID-19 pandemic on quality of life and mental health in children and adolescents in Germany The COVID-19 pandemic has caused unprecedented changes in the lives of 1.6 billion children and adolescents. First non-representative studies from China, India, Brazil, the US, Spain, Italy, and Germany pointed to a negative ...
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2020-11-12ZeitschriftenartikelDifferential Efficacy of Novel Antiviral Substances in 3D and Monolayer Cell Culture Repurposing of approved drugs that target host functions also important for virus replication promises to overcome the shortage of antiviral therapeutics. Mostly, virus biology including initial screening of antivirals is ...
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2020-01-21ZeitschriftenartikelThe European tiered approach for virucidal efficacy testing – rationale for rapidly selecting disinfectants against emerging and re-emerging viral diseases When facing an emerging virus outbreak such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a quick reaction time is key to control the spread. It takes time to develop antivirals and vaccines, and implement ...
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2020-12-19ZeitschriftenartikelHow Many Older Informal Caregivers Are There in Europe? Comparison of Estimates of Their Prevalence from Three European Surveys Informal caregivers are people providing some type of unpaid, ongoing assistance to a person with a chronic illness or disability. Long-term care measures and policies cannot take place without taking into account the ...
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2020-12-04ZeitschriftenartikelRe-assembly of nineteenth-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the USA According to a recent article published in Genome Biology, Duggan and coworkers sequenced and partially assembled five genomes of smallpox vaccines from the nineteenth century. No information regarding the ends of genomes ...
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2020-12-24ZeitschriftenartikelFirst detection of bat-borne Issyk-Kul virus in Europe Bats have been gaining attention as potential reservoir hosts of numerous viruses pathogenic to animals and man. Issyk-Kul virus, a member of the family Nairoviridae, was first isolated in the 1970s from vespertilionid ...
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2020-12-31ZeitschriftenartikelReflections on key methodological decisions in national burden of disease assessments Background: Summary measures of population health are increasingly used in different public health reporting systems for setting priorities for health care and social service delivery and planning. Disability-adjusted ...
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2021-01-01ZeitschriftenartikelHeteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors Here, we report the topology-matched design of heteromultivalent nanostructures as potent and broad-spectrum virus entry inhibitors based on the host cell membrane. Initially, we investigate the virus binding dynamics to ...
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2020-10-08ZeitschriftenartikelA decade of de novo transcriptome assembly: Are we there yet? A decade ago, de novo transcriptome assembly evolved as a versatile and powerful approach to make evolutionary assumptions, analyse gene expression, and annotate novel transcripts, in particular, for non‐model organisms ...
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2020-10-09ZeitschriftenartikelMonoklonale Antikörper zur antiinfektiven Therapie Ein Jahrhundert lang wurde die Serumtherapie von Seren tierischen Ursprungs und Hyperimmunglobulinen dominiert. Obwohl seit Ende der Achtzigerjahre des letzten Jahrhunderts zahlreiche monoklonale Antikörper (MAB) insbesondere ...
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2020-12-22ZeitschriftenartikelSurgical hand preparation in an equine hospital: Comparison of general practice with a standardised protocol and characterisation of the methicillin-resistant Staphylococcus aureus recovered Presurgical hand asepsis is part of the daily routine in veterinary medicine. Nevertheless, basic knowledge seems to be low, even among specialised veterinary surgeons. The major objectives of our study were to assess ...