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2006-07-01Zeitschriftenartikel DOI: 10.25646/467
Chemoprophylaxis and Malaria Death Rates
dc.contributor.authorKrause, Gérard
dc.contributor.authorSchöneberg, Irene
dc.contributor.authorAltmann, Doris
dc.contributor.authorStark, Klaus
dc.date.accessioned2018-05-07T13:34:44Z
dc.date.available2018-05-07T13:34:44Z
dc.date.created2009-12-18
dc.date.issued2006-07-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/re21cJSxJgQv2/PDF/29OSmosxC2QsA.pdf
dc.identifier.urihttp://edoc.rki.de/176904/542
dc.description.abstractTo determine the effect of chemoprophylaxis on the case-fatality rate of malaria, we analyzed all cases of Plasmodium falciparum malaria in nonimmune persons reported from 1993 to 2004 in Germany. In univariate and multivariate logistic regression analysis, we determined the effect of age, sex, chemoprophylaxis, chemoprophylactic regimen, compliance for chemoprophylactic regimen, exposure prophylaxis, country of infection, and year of reporting on the outcome. Of 3,935 case-patients, 116 (3%) died of malaria. Univariate analysis showed significant associations with death for chemoprophylaxis with chloroquine plus proguanil compared to no chemoprophylaxis. The multivariate model showed that patients who had taken chemoprophylaxis were less likely to die compared to those who had not taken chemoprophylaxis, adjusted for patient age and reporting year. The study demonstrated that chemoprophylaxis significantly reduced fatality rates among nonimmune malaria patients and supports the importance of existing guidelines for malaria prevention.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectGermanyeng
dc.subjectTraveleng
dc.subjectMaleeng
dc.subjectRisk Factorseng
dc.subjectMultivariate Analysiseng
dc.subjectRetrospective Studieseng
dc.subjectOdds Ratioeng
dc.subjectMalariaeng
dc.subjectFalciparum/mortalityeng
dc.subjectTime Factorseng
dc.subjectAntimalarials/therapeutic useeng
dc.subjectFalciparum/drug therapyeng
dc.subject.ddc610 Medizin
dc.titleChemoprophylaxis and Malaria Death Rates
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-1004405
dc.identifier.doihttp://dx.doi.org/10.25646/467
local.edoc.container-titleEmerging Infectious Diseases
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.cdc.gov/ncidod/eid/vol12no03/05-0736.htm
local.edoc.container-publisher-nameCenters for Disease Control and Prevention
local.edoc.container-volume12
local.edoc.container-issue3
local.edoc.container-year2006

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