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2007-06-01Zeitschriftenartikel DOI: 10.1086/517503
Successful termination of a furunculosis outbreak due to lukS-lukF-positive, methicillin-susceptible Staphylococcus aureus in a German village by stringent decolonization, 2002-2005
dc.contributor.authorWiese-Posselt, Miriam
dc.contributor.authorHeuck, Dagmar
dc.contributor.authorDraeger, Andreas
dc.contributor.authorMielke, Martin
dc.contributor.authorWitte, Wolfgang
dc.contributor.authorAmmon, Andrea
dc.contributor.authorHamouda, Osamah
dc.date.accessioned2018-05-07T13:50:09Z
dc.date.available2018-05-07T13:50:09Z
dc.date.created2010-04-23
dc.date.issued2007-06-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reVrLAMlWIyjM/PDF/27rm6XhhpDtys.pdf
dc.identifier.urihttp://edoc.rki.de/176904/626
dc.description.abstractBackground: Skin infections due to Staphylococcus aureus have recently become a public concern, mainly because of emerging resistance against widely used antibiotics and specific virulence determinants. Strains harboring the lukS-lukF gene (which codes for Panton-Valentine leukocidin) are frequently associated with severe furunculosis. Generally applicable strategies for the control of community outbreaks of furunculosis have not been defined. Methods: We report the investigation and successful termination of an outbreak of furunculosis due to lukS-lukF-positive S. aureus in a German village (n=144). Nasal swab specimens were obtained from village residents. A retrospective cohort study was conducted. Nasally colonized persons, persons who had current furuncles or who had experienced relapsing furuncles since 2002, and their family members underwent stringent decolonization measures using mupirocin nasal ointment and disinfecting wash solution. Multiple nasal swab specimens were obtained to monitor the long-term outcome of decolonization measures. Results: From January 1998 through December 2004, 42 cases and 59 relapses of furunculosis were identified by active case finding. Of 140 participants tested, 51 (36%) were found to be nasally colonized with S. aureus. In 9 participants, the strain was positive for lukS-lukF. No methicillin resistance was detected. Risk of furunculosis was associated with contact with case patients (relative risk, 6.8; 95% confidence interval, 3.2-14.3) and nasal colonization with a lukS-lukF-positive strain of S. aureus (relative risk, 3.6; 95% confidence interval, 2.3-5.9). Passive surveillance implemented in January 2005 did not detect any case of lukS-lukF-positive, S. aureus-associated furuncles in this village. Conclusion: This report describes a successful strategy for terminating the transmission of epidemic strains of S. aureus among a nonhospitalized population.ger
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectAdolescenteng
dc.subject80 and overeng
dc.subjectPreschooleng
dc.subjectNewborneng
dc.subjectBacterialeng
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectGermanyeng
dc.subjectMaleeng
dc.subjectMiddle Agedeng
dc.subjectRisk Factorseng
dc.subjectChildeng
dc.subjectAdulteng
dc.subjectCohort Studieseng
dc.subjectAgedeng
dc.subjectInfanteng
dc.subjectRetrospective Studieseng
dc.subjectDrug Resistanceeng
dc.subjectDisease Outbreaks/prevention & controleng
dc.subjectAnti-Bacterial Agents/therapeutic useeng
dc.subjectBacterial Proteins/geneticseng
dc.subjectFurunculosis/drug therapyeng
dc.subjectFurunculosis/epidemiologyeng
dc.subjectFurunculosis/microbiologyeng
dc.subjectLeukocidins/geneticseng
dc.subjectMethicillin Resistanceeng
dc.subjectMicrobial Sensitivity Testseng
dc.subjectMupirocin/administration & dosageeng
dc.subjectMupirocin/therapeutic useeng
dc.subjectStaphylococcus aureus/drug effectseng
dc.subjectStaphylococcus aureus/geneticseng
dc.subjectStaphylococcus aureus/isolation & purificationeng
dc.subjectTreatment Outcomeeng
dc.subject.ddc610 Medizin
dc.titleSuccessful termination of a furunculosis outbreak due to lukS-lukF-positive, methicillin-susceptible Staphylococcus aureus in a German village by stringent decolonization, 2002-2005
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-1008397
dc.identifier.doi10.1086/517503
dc.identifier.doihttp://dx.doi.org/10.25646/551
local.edoc.container-titleClinical Infectious Diseases
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.journals.uchicago.edu
local.edoc.container-publisher-nameUniversity of Chicago Press
local.edoc.container-volume44
local.edoc.container-issue11
local.edoc.container-year2007

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