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2019-07-16Zeitschriftenartikel DOI: 10.25646/6332
Transmission of Porcine Circovirus 3 (PCV3) by Xenotransplantation of Pig Hearts into Baboons
Krüger, Luise
Längin, Matthias
Reichart, Bruno
Fiebig, Uwe
Kristiansen, Yannick
Prinz, Carolin
Kessler, Barbara
Egerer, Stefanie
Wolf, Eckhard
Abicht, Jan-Michael
Denner, Joachim
Porcine circovirus 3 (PCV3) is a newly described member of the virus family Circoviridae. PCV3 is highly distributed among pigs and wild boars worldwide. A sudden introduction of PCV3 was recently observed in a herd of triple genetically modified pigs generated for xenotransplantation. These animals were used as donor pigs for orthotopic heart transplantation into baboons. In four cases, PCV3-positive hearts were transplanted, and transmission of PCV3 to the recipient was observed. PCV3 was found in all organs of the recipient baboons and a higher virus load was found in animals with a longer survival time of the transplant, indicating replication of the virus. This is the first report showing trans-species transmission of PCV3 to baboons by transplantation of a heart from a PCV3-positive donor pig. Sequence analysis showed that PCV3a and PCV3b were present in the infected pigs and were transmitted. Experiments to infect human 293 cells with PCV3 failed.
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DOI
10.25646/6332
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http://dx.doi.org/10.25646/6332
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<a href="http://dx.doi.org/10.25646/6332">http://dx.doi.org/10.25646/6332</a>