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2019-07-16Zeitschriftenartikel DOI: 10.25646/6332
Transmission of Porcine Circovirus 3 (PCV3) by Xenotransplantation of Pig Hearts into Baboons
dc.contributor.authorKrüger, Luise
dc.contributor.authorLängin, Matthias
dc.contributor.authorReichart, Bruno
dc.contributor.authorFiebig, Uwe
dc.contributor.authorKristiansen, Yannick
dc.contributor.authorPrinz, Carolin
dc.contributor.authorKessler, Barbara
dc.contributor.authorEgerer, Stefanie
dc.contributor.authorWolf, Eckhard
dc.contributor.authorAbicht, Jan-Michael
dc.contributor.authorDenner, Joachim
dc.date.accessioned2019-10-25T07:15:27Z
dc.date.available2019-10-25T07:15:27Z
dc.date.issued2019-07-16none
dc.identifier.other10.3390/v11070650
dc.identifier.urihttp://edoc.rki.de/176904/6344
dc.description.abstractPorcine circovirus 3 (PCV3) is a newly described member of the virus family Circoviridae. PCV3 is highly distributed among pigs and wild boars worldwide. A sudden introduction of PCV3 was recently observed in a herd of triple genetically modified pigs generated for xenotransplantation. These animals were used as donor pigs for orthotopic heart transplantation into baboons. In four cases, PCV3-positive hearts were transplanted, and transmission of PCV3 to the recipient was observed. PCV3 was found in all organs of the recipient baboons and a higher virus load was found in animals with a longer survival time of the transplant, indicating replication of the virus. This is the first report showing trans-species transmission of PCV3 to baboons by transplantation of a heart from a PCV3-positive donor pig. Sequence analysis showed that PCV3a and PCV3b were present in the infected pigs and were transmitted. Experiments to infect human 293 cells with PCV3 failed.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectporcine circovirus 3 (PCV3)eng
dc.subjectpigseng
dc.subjectnon-human primateseng
dc.subjectxenotransplantationeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleTransmission of Porcine Circovirus 3 (PCV3) by Xenotransplantation of Pig Hearts into Baboonsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/6344-2
dc.identifier.doihttp://dx.doi.org/10.25646/6332
dc.type.versionpublishedVersionnone
local.edoc.container-titleVirusesnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/1999-4915/11/7/650/htmnone
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume7none
local.edoc.container-issue650none
local.edoc.container-reportyear2019none
local.edoc.container-year2019none
local.edoc.container-firstpage1none
local.edoc.container-lastpage11none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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