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2021-05-31Zeitschriftenartikel
Low Proportion of Linezolid and Daptomycin Resistance Among Bloodborne Vancomycin-Resistant Enterococcus faecium and Methicillin-Resistant Staphylococcus aureus Infections in Europe
dc.contributor.authorMarkwart, Robby
dc.contributor.authorWillrich, Niklas
dc.contributor.authorEckmanns, Tim
dc.contributor.authorWerner, Guido
dc.contributor.authorAyobami, Olaniyi
dc.date.accessioned2022-02-01T10:46:04Z
dc.date.available2022-02-01T10:46:04Z
dc.date.issued2021-05-31none
dc.identifier.other10.3389/fmicb.2021.664199
dc.identifier.urihttp://edoc.rki.de/176904/9313
dc.description.abstractVancomycin-resistant Enterococcus faecium (VREF) and methicillin-resistant Staphylococcus aureus (MRSA) are associated with significant health burden. We investigated linezolid and daptomycin resistance among VREF and MRSA in the EU/EEA between 2014 and 2018. Descriptive statistics and multivariable logistic regression were used to analyze 6,949 VREF and 35,131 MRSA blood isolates from patients with bloodstream infection. The population-weighted mean proportion of linezolid resistance in VREF and MRSA between 2014 and 2018 was 1.6% (95% CI 1.33–2.03%) and 0.28% (95% CI 0.32–0.38%), respectively. Daptomycin resistance in MRSA isolates was similarly low [1.1% (95% CI 0.75–1.6%)]. On the European level, there was no temporal change of daptomycin and linezolid resistance in MRSA and VREF. Multivariable regression analyses showed that there was a higher likelihood of linezolid and daptomycin resistance in MRSA (aOR: 2.74, p < 0.001; aOR: 2.25, p < 0.001) and linezolid in VREF (aOR: 1.99, p < 0.001) compared to their sensitive isolates. The low proportion of linezolid and daptomycin resistance in VREF and MRSA suggests that these last-resort antibiotics remain effective and will continue to play an important role in the clinical management of these infections in Europe. However, regional and national efforts to contain antimicrobial resistance should continue to monitor the trend through strengthened surveillance that includes genomic surveillance for early warning and action.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectvancomycin-resistant Enterococcus faeciumeng
dc.subjectmethicillin-resistant Staphylococcus aureuseng
dc.subjectdaptomycineng
dc.subjectlinezolideng
dc.subjectlast-resort antibioticseng
dc.subjectantimicrobial resistanceeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleLow Proportion of Linezolid and Daptomycin Resistance Among Bloodborne Vancomycin-Resistant Enterococcus faecium and Methicillin-Resistant Staphylococcus aureus Infections in Europenone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/9313-6
dc.type.versionpublishedVersionnone
local.edoc.container-titleMicrobiologynone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.664199/fullnone
local.edoc.container-publisher-nameFrontiersnone
local.edoc.container-volume12none
local.edoc.container-year2021none
local.edoc.container-firstpage1none
local.edoc.container-lastpage12none
dc.description.versionPeer Reviewednone

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