2010-07-29Zeitschriftenartikel DOI: 10.1097/INF.0b013e3181ef22d5
Hepatitis B virus infections among children and adolescents in Germany: Migration background as a risk factor in a low seroprevalence population
Background: Data on hepatitis B (HB) infection prevalence among children and adolescents in Germany are scarce. We estimated seroprevalence of HB infection and assessed determinants for HB infection among children and adolescents in Germany from a representative population sample. Methods: From 2003 to 2006, the Robert Koch Institute conducted a nationwide cross-sectional Health Interview and Examination Survey for Children and Adolescents in Germany. Data on age, gender, migration background, and socioeconomic status were collected through questionnaires. A child was defined as having a 2-sided migration background if both parents, or the child and 1 parent, immigrated, and a 1-sided migration background if only 1 parent immigrated. Among children with migration background, a first-generation migrant was defined as born outside Germany; a second-generation migrant was born in Germany. Information on HB vaccination status was obtained from vaccination cards. Serologic samples from participants were tested for anti-hepatitis B core antigen (anti-HBc) and hepatitis B surface antigen. We performed weighted univariable and multivariable logistic regression analyses to assess determinants for HB infection. Results: Of 13,065 participants (3–17 years), 0.5% (95% confidence interval [CI], 0.4–0.7) were anti-HBc positive, among whom 38.7% (95% CI, 20.0–57.5) were hepatitis B surface antigen positive. Two-sided migration background and being a first- or second-generation migrant were significantly associated with anti-HBc positivity (odds ratio [OR]: 8.3, 95% CI: 4.0–17.4; OR: 11.0, 95% CI: 3.5–35.0; OR: 3.0, 95% CI: 1.2–7.3). No further determinants were found. Conclusions: HB infection is rare among children and adolescents in Germany. First- and second-generation migrant children can be considered to be at risk for HB infection, 2-sided migration background or being a first-generation migrant carried the greatest risk. Targeted testing for HB infection and early HB vaccination should be provided to immigrants' children.
No license information
Show related Items with similar Title, Author, Creator or Subject.
2015-07-06ZeitschriftenartikelOccult Hepatitis B Virus Infection in Nigerian Blood Donors and Hepatitis B Virus Transmission Risks Oluyinka, Opaleye O.; Tong, Hoang Van; Tien, Sy Bui; Fagbami, Ademola H.; Adekanle, Olusegun; Ojurongbe, Olusola; Bock, Thomas; Kremsner, Peter G.; Velavan, Thirumalaisamy P.Background: Occult hepatitis B virus infection (OBI) characterized by the absence of detectable HBsAg remains a potential threat in blood safety. We investigated the actual prevalence, viral factors and genotype of OBI ...
2014-05-16ZeitschriftenartikelMolecular Epidemiology and Genotyping of Hepatitis B Virus of HBsAg-Positive Patients in Oman Baqlani, Said Ali Al; Sy, Bui Tien; Ratsch, Boris A.; Naamani, Khalid Al; Awaidy, Salah Al; Busaidy, Suleiman Al; Pauli, Georg; Bock, ThomasBackground: Hepatitis B virus (HBV) infection is a major global health burden with distinct geographic public health significance. Oman is a country with intermediate HBV carrier prevalence; however, little is known ...
2013-10-18ZeitschriftenartikelHigh Prevalence and Significance of Hepatitis D Virus Infection among Treatment-Naïve HBsAg-Positive Patients in Northern Vietnam Sy, Bui Tien; Ratsch, Boris A.; Toan, Nguyen Linh; Song, Le Huu; Wollboldt, Christian; Bryniok, Agnes; Nguyen, Hung Minh; Luong, Hoang Van; Velavan, Thirumalaisamy P.; Wedemeyer, Heiner; Kremsner, Peter G.; Bock, ThomasBackground: Hepatitis D virus (HDV) infection is considered to cause more severe hepatitis than hepatitis B virus (HBV) monoinfection. With more than 9.5 million HBV-infected people, Vietnam will face an enormous health ...