Hepatitis B virus infections among children and adolescents in Germany: Migration background as a risk factor in a low seroprevalence population
dc.contributor.author | Cai, Wei | |
dc.contributor.author | Poethko-Müller, Christina | |
dc.contributor.author | Hamouda, Osamah | |
dc.contributor.author | Radun, Doris | |
dc.date.accessioned | 2018-05-07T14:53:55Z | |
dc.date.available | 2018-05-07T14:53:55Z | |
dc.date.created | 2011-10-14 | |
dc.date.issued | 2010-07-29 | none |
dc.identifier.other | http://edoc.rki.de/oa/articles/reGXTHdYqaEk/PDF/25aZV8eSflMM.pdf | |
dc.identifier.uri | http://edoc.rki.de/176904/970 | |
dc.description.abstract | Background: Data on hepatitis B (HB) infection prevalence among children and adolescents in Germany are scarce. We estimated seroprevalence of HB infection and assessed determinants for HB infection among children and adolescents in Germany from a representative population sample. Methods: From 2003 to 2006, the Robert Koch Institute conducted a nationwide cross-sectional Health Interview and Examination Survey for Children and Adolescents in Germany. Data on age, gender, migration background, and socioeconomic status were collected through questionnaires. A child was defined as having a 2-sided migration background if both parents, or the child and 1 parent, immigrated, and a 1-sided migration background if only 1 parent immigrated. Among children with migration background, a first-generation migrant was defined as born outside Germany; a second-generation migrant was born in Germany. Information on HB vaccination status was obtained from vaccination cards. Serologic samples from participants were tested for anti-hepatitis B core antigen (anti-HBc) and hepatitis B surface antigen. We performed weighted univariable and multivariable logistic regression analyses to assess determinants for HB infection. Results: Of 13,065 participants (3–17 years), 0.5% (95% confidence interval [CI], 0.4–0.7) were anti-HBc positive, among whom 38.7% (95% CI, 20.0–57.5) were hepatitis B surface antigen positive. Two-sided migration background and being a first- or second-generation migrant were significantly associated with anti-HBc positivity (odds ratio [OR]: 8.3, 95% CI: 4.0–17.4; OR: 11.0, 95% CI: 3.5–35.0; OR: 3.0, 95% CI: 1.2–7.3). No further determinants were found. Conclusions: HB infection is rare among children and adolescents in Germany. First- and second-generation migrant children can be considered to be at risk for HB infection, 2-sided migration background or being a first-generation migrant carried the greatest risk. Targeted testing for HB infection and early HB vaccination should be provided to immigrants' children. | eng |
dc.language.iso | eng | |
dc.publisher | Robert Koch-Institut, Infektionsepidemiologie | |
dc.subject | Adolescent | eng |
dc.subject | Humans | eng |
dc.subject | Female | eng |
dc.subject | Germany/epidemiology | eng |
dc.subject | Male | eng |
dc.subject | Population Surveillance | eng |
dc.subject | Risk Factors | eng |
dc.subject | Child | eng |
dc.subject | Seroepidemiologic Studies | eng |
dc.subject | Cross-Sectional Studies | eng |
dc.subject | Regression Analysis | eng |
dc.subject | Analysis of Variance | eng |
dc.subject | Child Preschool | eng |
dc.subject | Hepatitis B/epidemiology | eng |
dc.subject | Hepatitis B/prevention & control | eng |
dc.subject | Emigration and Immigration/statistics & numerical data | eng |
dc.subject | Hepatitis B/blood | eng |
dc.subject | Hepatitis B Antibodies/blood | eng |
dc.subject | Hepatitis B Core Antigens/blood | eng |
dc.subject | Hepatitis B Vaccines/administration & dosage | eng |
dc.subject | National Health Programs | eng |
dc.subject.ddc | 610 Medizin | |
dc.title | Hepatitis B virus infections among children and adolescents in Germany: Migration background as a risk factor in a low seroprevalence population | |
dc.type | periodicalPart | |
dc.identifier.urn | urn:nbn:de:0257-10015715 | |
dc.identifier.doi | 10.1097/INF.0b013e3181ef22d5 | |
dc.identifier.doi | http://dx.doi.org/10.25646/895 | |
local.edoc.container-title | Pediatric Infectious Disease Journal | |
local.edoc.container-text | Cai, W., Poethko-Müller, C., Hamouda, O., Radun, D. Hepatitis B virus infections among children and adolescents in Germany: Migration background as a risk factor in a low seroprevalence population (2011) Pediatric Infectious Disease Journal, 30 (1), pp. 19-24. | |
local.edoc.fp-subtype | Artikel | |
local.edoc.type-name | Zeitschriftenartikel | |
local.edoc.container-type | periodical | |
local.edoc.container-type-name | Zeitschrift | |
local.edoc.container-url | http://journals.lww.com/pidj/Abstract/2011/01000/Hepatitis_B_Virus_Infections_Among_Children_and.7.aspx | |
local.edoc.container-publisher-name | Lippincott, Williams & Wilkins | |
local.edoc.container-volume | 30 | |
local.edoc.container-issue | 1 | |
local.edoc.container-year | 2011 |