Zur Kurzanzeige

2010-11-11Zeitschriftenartikel DOI: 10.1002/eji.201040576
Reduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE
dc.contributor.authorGültner, Sandra
dc.contributor.authorKuhlmann, Tanja
dc.contributor.authorHesse, Amke
dc.contributor.authorWeber, Jan P.
dc.contributor.authorRiemer, Constanze
dc.contributor.authorBaier, Michael
dc.contributor.authorHutloff, Andreas
dc.date.accessioned2018-05-07T14:58:38Z
dc.date.available2018-05-07T14:58:38Z
dc.date.created2011-11-11
dc.date.issued2010-11-11none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reIpi6mmqlZd6/PDF/27Xajfo7Wp31I.pdf
dc.identifier.urihttp://edoc.rki.de/176904/996
dc.description.abstractThe αLβ2-integrin LFA-1 (CD11a/CD18) is known as an important molecule for leukocyte migration. However, the precise role of LFA-1 in the pathogenesis of EAE has so far remained unclear. We describe here the disease development in LFA-1(-/-) mice compared with WT controls. Ablation of LFA-1 resulted in more severe EAE with increased demyelination and increased numbers of myelin oligodendrocyte glycoprotein-reactive CD4(+) T cells in the CNS. However, the production of the pro-inflammatory cytokines IL-17 and IFN-γ was unchanged on the level of antigen-specific T cells. Interestingly, LFA-1-deficient mice showed a clearly reduced frequency of Treg in the inflamed CNS. Moreover, Treg counts in spleens and thymi of unimmunized LFA-1(-/-) mice were lower in comparison to the WT controls, indicating an impairment of Treg generation. In combination, these results suggest a substantial role of LFA-1 in Treg generation and subsequent expansion of effector T cells and highlight the importance of Treg in limiting EAE.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectAutoimmunityeng
dc.subjectNeuroimmunologyeng
dc.subjectTregeng
dc.subject.ddc610 Medizin
dc.titleReduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10016104
dc.identifier.doi10.1002/eji.201040576
dc.identifier.doihttp://dx.doi.org/10.25646/921
local.edoc.container-titleEuropean Journal of Immunology
local.edoc.container-textGültner, S., Kuhlmann, T., Hesse, A., Weber, J.P., Riemer, C., Baier, M., Hutloff, A. Reduced treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE (2010) European Journal of Immunology, 40 (12), pp. 3403-3412.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://onlinelibrary.wiley.com/doi/10.1002/eji.201040576/abstract
local.edoc.container-publisher-nameWiley
local.edoc.container-volume40
local.edoc.container-issue12
local.edoc.container-year2010

Zur Kurzanzeige