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2022-11-17ZeitschriftenartikelLatin American Internet Survey for Men who have Sex with Men (LAMIS-2018): Design, methods and implementation Despite men-who-have-sex-with-men (MSM) from Latin America (LA) are still a vulnerable population for known health-related conditions and social problems, availability of comparable data across LA countries for assessment ...
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2022-07-27ZeitschriftenartikelFew Amino Acid Mutations in H6 Influenza A Virus From South American Lineage Increase Viral Replication Efficiency in Poultry In chickens, infections due to influenza A virus (IAV) can be mild to severe and lethal. The study of IAV infections in poultry has been mostly limited to strains from the North American and Eurasian lineages, whereas ...
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2022-11-10ZeitschriftenartikelPost-COVID-19-associated morbidity in children, adolescents, and adults: A matched cohort study including more than 157,000 individuals with COVID-19 in Germany Background Long-term health sequelae of the Coronavirus Disease 2019 (COVID-19) are a major public health concern. However, evidence on post-acute COVID-19 syndrome (post-COVID-19) is still limited, particularly for ...
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2022-04-04ZeitschriftenartikelEffects of caloric restriction on the gut microbiome are linked with immune senescence Background Caloric restriction can delay the development of metabolic diseases ranging from insulin resistance to type 2 diabetes and is linked to both changes in the composition and metabolic function of the gut ...
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2022-07-17ZeitschriftenartikelMolecular epidemiology and genotype-specific disease severity of hepatitis E virus infections in Germany, 2010–2019 Zoonotic hepatitis E virus (HEV) is endemic in Europe. Genotype 3 (HEV-3) is predominant but information on subtype distribution, trends and clinical implications in Germany is scarce. We analysed 936 HEV RNA positive ...
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2022-09-21Zeitschriftenartikel3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseases Pandemic outbreaks of viruses such as influenza virus or SARS-CoV-2 are associated with high morbidity and mortality and thus pose a massive threat to global health and economics. Physiologically relevant models are needed ...
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2022-12-08ZeitschriftenartikelImbalance of peptidoglycan biosynthesis alters the cell surface charge of Listeria monocytogenes The bacterial cell wall is composed of a thick layer of peptidoglycan and cell wall polymers, which are either embedded in the membrane or linked to the peptidoglycan backbone and referred to as lipoteichoic acid (LTA) and ...
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2022-12-15ZeitschriftenartikelAnalysing cerebrospinal fluid with explainable deep learning: From diagnostics to insights Aim Analysis of cerebrospinal fluid (CSF) is essential for diagnostic workup of patients with neurological diseases and includes differential cell typing. The current gold standard is based on microscopic examination ...
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2022-10-07ZeitschriftenartikelKinetics of the reduction of Creutzfeldt–Jakob disease prion seeding activity by steam sterilization support the use of validated 134°C programmes Background Prions are renowned for their distinct resistance to chemical or physical inactivation, including steam sterilization. Impaired efficacy of inactivation poses a risk to patients for iatrogenic transmission ...
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2022-07-07ZeitschriftenartikelA shift from travel-associated cases to autochthonous transmission with Berlin as epicentre of the monkeypox outbreak in Germany, May to June 2022 By 22 June 2022, 521 cases of monkeypox were notified in Germany. The median age was 38 years (IQR: 32–44); all cases were men. In Berlin, where 69% of all cases occurred, almost all were men who have sex with men. Monkeypox ...
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2022-03-07ZeitschriftenartikelPathways of Parental Education on Children's and Adolescent's Body Mass Index: The Mediating Roles of Behavioral and Psychological Factors Aim: The increasing body mass index (BMI) often followed by overweight and obesity is a global health problem of the 21st century. Children and adolescents with lower socioeconomic status are more affected than their ...
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2022-06-28ZeitschriftenartikelBAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors Binding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the same levels of BAFFR, but only memory ...
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2022-03-15ZeitschriftenartikelFirst Report of a Methicillin-Resistant, High-Level Mupirocin-Resistant Staphylococcus argenteus We describe the identification of a methicillin-resistant, high-level mupirocin-resistant Staphylococcus argenteus. The isolate (1801221) was characterized as t6675-ST2250-SCCmecIVc, and whole-genome sequencing revealed ...
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202-05-31ZeitschriftenartikelOrigin and Global Expansion of Mycobacterium tuberculosis Complex Lineage 3 Tuberculosis still causes 1.5 million deaths annually and is mainly caused by Mycobacterium tuberculosis complex strains belonging to three evolutionary modern lineages (Lineages 2–4). While Lineage 2 and Lineage 4 virtually ...
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2022-10-20ZeitschriftenartikelWater flow through bone: Neutron tomography reveals differences in water permeability between osteocytic and anosteocytic bone material Vertebrate bones are made of a nanocomposite consisting of water, mineral and organics. Water helps bone material withstand mechanical stress and participates in sensation of external loads. Water diffusion across vertebrae ...
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2022-09-01ZeitschriftenartikelSARS-CoV-2 variants and the risk of pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 among children in Germany Purpose To investigate the relationship between the risk of pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in children and the predominance of different SARS-CoV-2 variants ...
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2022-11-10ZeitschriftenartikelParticipatory development and implementation of inclusive digital health communication on COVID-19 with homeless people Introduction: People experiencing homelessness (PEH) are disproportionally affected by the COVID-19 pandemic. The realities of their daily lives have been given little consideration in the pandemic response. They are not ...
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2022-03-04ZeitschriftenartikelMethodological guidance for rapid reviews in healthcare: A scoping review The aim of the present work was to identify published methodological guidance for rapid reviews (RRs) and to analyze the recommendations with regard to time-saving measures. A literature search was performed in PubMed and ...
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2022-06-01ZeitschriftenartikelSocial Inequalities in the Association between Social Infrastructure and Mental Health: An Observational Cross-Sectional Analysis of Children and Adolescents in Germany The mental health (MH) of especially children and adolescents with low socioeconomic status (SES) benefits from access to greenspaces. This study aimed at investigating social inequalities in the association between several ...
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2022-06-20ZeitschriftenartikelEditorial: Humanitarian Health in Conflict and Violence Settings