edoc.rki.de - Open Access Publikationsserver: Neuzugänge
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2024-04-04ZeitschriftenartikelProtein G affinity chromatography is an underrated but very potent purification method for a broad range of species-independent and tag-less Fab-fragments Because of their superior properties for certain biological applications small antibody derivatives like fragment of antigen binding (Fab) have found widespread use in basic research and as therapeutics. However, generation ...
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2024-08-06ZeitschriftenartikelRoutine Data Analysis of HIV Pre-Exposure Prophylaxis Use and Rates of Sexually Transmitted Infections Since Coverage of HIV Pre-Exposure Prophylaxis by the Statutory Health Insurance in Germany Human immunodeficiency virus pre-exposure prophylaxis (PrEP) is considered as an effective protection against a human immunodeficiency virus (HIV) infection. However, it is still unclear, how PrEP use is associated with ...
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2024-03-03ZeitschriftenartikelAntimicrobial susceptibility prediction from genomes: a dream come true? Genome-based diagnostics provides relevant information to guide patient treatment and support pathogen and resistance surveillance. Recently, Coll et al. introduced a curated database for predicting antimicrobial resistance ...
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2023-03-29ZeitschriftenartikelDiminishing benefits of urban living for children and adolescents’ growth and development Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1,2,3,4,5,6. Here we used data from 2,325 population-based studies, with measurements of height and weight from ...
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2023-07-19ZeitschriftenartikelEnterovirus A71-associated acute flaccid paralysis in a pediatric patient: a case report Background: Enterovirus A71 is one of the causative agents of hand, foot, and mouth disease, which is usually a self-limiting disease. Complications of enterovirus infection are also very rare. However, when such ...
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2023-11-09ZeitschriftenartikelLysinibacillus irui sp. nov., isolated from Iru, fermented African locust beans A Gram-positive, motile, aerobic, rod-shaped, endospore-forming strain designated IRB4-01T was isolated from fermented African locust beans (Iru) obtained from Bodija market in the city of Ibadan, southwestern Nigeria, ...
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2023-12-10ZeitschriftenartikelAreas with high HIV prevalence: A spatial analysis of nationwide claims data in Germany Objective: We aimed to identify spatial clusters of high HIV prevalence in Germany. Methods: Using nationwide outpatient claims data comprising information of about 88% of the total German population (N = 72 041 683), ...
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2023-04-19ZeitschriftenartikelNorovirus acute gastroenteritis amongst US and European travellers to areas of moderate to high risk of travellers’ diarrhoea: a prospective cohort study Background: Acute gastroenteritis (AGE) is a major medical condition for travellers worldwide, particularly travellers to low- and middle-income countries. Norovirus (NoV) is the most common cause of viral AGE in older ...
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2023-01-07ZeitschriftenartikelSuccessful Treatment of Complicated Influenza A(H3N2) Virus Infection and Rhabdomyolysis with Compassionate Use of IV Zanamivir In 2019, EMA licensed intravenous (IV) zanamivir for severe influenza virus infection in children over 6 months as well as adults. Prior to that, it was possible via a compassionate use program. We present successful ...
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2023-09-07ZeitschriftenartikelMicroRNAs As Novel Biomarkers and Potential Therapeutic Options for Inflammatory Cardiomyopathy Aims: Inflammation of the heart is a complex biological and pathophysiological response of the immune system to a variety of injuries leading to tissue damage and heart failure. MicroRNAs (miRNAs) emerge as pivotal ...
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2023-05-30ZeitschriftenartikelDetection of bornavirus-reactive antibodies and BoDV-1 RNA only in encephalitis patients from virus endemic areas: a comparative serological and molecular sensitivity, specificity, predictive value, and disease duration correlation study Purpose: Human Borna disease virus (BoDV-1) encephalitis is an emerging disease in Germany. This study investigates the spectrum of human BoDV-1 infection, characterizes anti-BoDV-1-antibodies and kinetics, and compares ...
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2023-07-28ZeitschriftenartikelInequalities in the burden of non-communicable diseases across European countries: a systematic analysis of the Global Burden of Disease 2019 study Background: Although overall health status in the last decades improved, health inequalities due to non-communicable diseases (NCDs) persist between and within European countries. There is a lack of studies giving ...
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2023-10-06ZeitschriftenartikelInteractive polar diagrams for model comparison Objective: Evaluating the performance of multiple complex models, such as those found in biology, medicine, climatology, and machine learning, using conventional approaches is often challenging when using various evaluation ...
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2023-04-04ZeitschriftenartikelHeterozygosity for cervid S138N polymorphism results in subclinical CWD in gene-targeted mice and progressive inhibition of prion conversion Prions are proteinaceous infectious particles that replicate by structural conversion of the host-encoded cellular prion protein (PrPC), causing fatal neurodegenerative diseases in mammals. Species-specific amino acid ...
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2023-02-21ZeitschriftenartikelLate Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses Toxoplasma gondii oocysts, which are shed in large quantities in the feces from infected felines, are very stable in the environment, resistant to most inactivation procedures, and highly infectious. The oocyst wall provides ...
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2023-10-14ZeitschriftenartikelCryptic susceptibility to penicillin/β-lactamase inhibitor combinations in emerging multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages Global spread of multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages underscores the need for new therapeutic strategies. Here we show that many S. epidermidis isolates belonging to these lineages ...
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2023-07-31ZeitschriftenartikelAdvancing Precision Medicine in Myocarditis: Current Status and Future Perspectives in Endomyocardial Biopsy-Based Diagnostics and Therapeutic Approaches The diagnosis and specific and causal treatment of myocarditis and inflammatory cardiomyopathy remain a major clinical challenge. Despite the rapid development of new imaging techniques, endomyocardial biopsies remain the ...
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2023-06-26ZeitschriftenartikelGenomic Evidence of mcr-1.26 IncX4 Plasmid Transmission between Poultry and Humans Colistin is still commonly used and misused in animal husbandry driving the evolution and dissemination of transmissible plasmid-mediated colistin resistance (mcr). mcr-1.26 is a rare variant and, so far, has only been ...
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2023-04-20ZeitschriftenartikelProtective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease: a systematic review and meta-regression Background: The global surge in the omicron (B.1.1.529) variant has resulted in many individuals with hybrid immunity (immunity developed through a combination of SARS-CoV-2 infection and vaccination). We aimed to ...
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2023-11-27ZeitschriftenartikelWhy are different estimates of the effective reproductive number so different? A case study on COVID-19 in Germany The effective reproductive number Rt has taken a central role in the scientific, political, and public discussion during the COVID-19 pandemic, with numerous real-time estimates of this quantity routinely published. ...