edoc.rki.de - Open Access Publikationsserver: Neuzugänge
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2018-03-08ZeitschriftenartikelDiphtherie Vollständig aktualisierte Fassung vom Januar 2018. Erstveröffentlichung im Epidemiologischen Bulletin 6/2001.Im Epidemiologischen Bulletin 10/2018 ist der vollständig überarbeitete RKI-Ratgeber für Ärzte zu Diphtherie erschienen. Seit 2001 wurden dem Robert Koch-Institut rund 90 Diphtherie-Erkrankungen übermittelt. Das klinische ...
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2018-02-20ZeitschriftenartikelStrain-dependent effects of clinical echovirus 30 outbreak isolates at the blood-CSF barrier Background: Echovirus (E) 30 (E-30) meningitis is characterized by neuroinflammation involving immune cell pleocytosis at the protective barriers of the central nervous system (CNS). In this context, infection of the ...
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2018-03-05ZeitschriftenartikelIntravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA) Seeding and spread of beta-amyloid (Aβ) pathologies have been considered to be based on prion-like mechanisms. However, limited transmissibility of Aβ seeding activity upon peripheral exposure would represent a key difference ...
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2018-02-23ZeitschriftenartikelWhole Genome Sequence Analysis of CTX-M-15 Producing Klebsiella Isolates Allowed Dissecting a Polyclonal Outbreak Scenario Extended-spectrum β-lactamase (ESBL) producing Klebsiella pneumoniae pose an important threat of infection with increased morbidity and mortality, especially for immunocompromised patients. Here, we use the rise of ...
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2018-03-01ZeitschriftenartikelVorstellung aktueller Informationen zu DEMIS Das Deutsche Elektronische Melde- und Informationssystem für den Infektionsschutz (DEMIS) ist Thema im Epidemiologischen Bulletin 9/2018. Um die zukünftigen Nutzer von DEMIS, darunter Melder und den ÖGD, über den aktuellen ...
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2018-02-16ZeitschriftenartikelTularemia in Germany—A Re-emerging Zoonosis Tularemia, also known as “rabbit fever,” is a zoonosis caused by the facultative intracellular, gram-negative bacterium Francisella tularensis. Infection occurs through contact with infected animals (often hares), arthropod ...
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2018-02-23ZeitschriftenartikelThe zoonotic potential of Clostridium difficile from small companion animals and their owners Background: Clostridium difficile infections (CDI) in humans range from asymptomatic carriage to life-threatening intestinal disease. Findings on C. difficile in various animal species and an overlap in ribotypes (RTs) ...
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2018-02-13ZeitschriftenartikelHERVs New Role in Cancer: From Accused Perpetrators to Cheerful Protectors Initial indications that retroviruses are connected to neoplastic transformation were seen more than a century ago. This concept has also been tested for endogenized retroviruses (ERVs) that are abundantly expressed in ...
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2018-02-12ZeitschriftenartikelRecombinant IFN-γ from the bank vole Myodes glareolus: a novel tool for research on rodent reservoirs of zoonotic pathogens Rodent species like Myodes glareolus and Microtus spp. are natural reservoirs for many zoonotic pathogens causing human diseases and are gaining increasing interest in the field of eco-immunology as candidate animal models. ...
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2018-02-22ZeitschriftenartikelCorynebacterium ulcerans – ein Emerging Pathogen? Daten des Konsiliarlabors für Diphtherie 2011 – 2016Im Epidemiologischen Bulletin 8/2018 werden die Daten des Konsiliarlabors für Diphtherie aus den Jahren 2011-2016 vorgestellt. Während in der Prävakzine-Ära und heute noch in Ländern mit inadäquaten Impfquoten hauptsächlich ...
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2017-01-24ZeitschriftenartikelMRE bei Mensch und Tier: Übertragungswege und Infektionsrisiko Livestock asssoziierte MRSA (LA-MRSA) sind bei konventionell gehaltenen Nutztieren als nasale Besiedler weit verbreitet. Sie stellen innerhalb der Species S. aureus eine eigene Subpopulation dar (klonaler Komplex CC398) ...
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2018-02-02ZeitschriftenartikelEditorial: Parasite Infections: From Experimental Models to Natural Systems
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2017-11-08ZeitschriftenartikelBystanders intervene to impede grooming in Western chimpanzees and sooty mangabeys Grooming interactions benefit groomers, but may have negative consequences for bystanders. Grooming limits bystanders' grooming access and ensuing alliances could threaten the bystander's hierarchy rank or their previous ...
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2018-01-26ZeitschriftenartikelSoziale Unterschiede bei den Notarztdiagnosen Herzinfarkt und Schlaganfall Eine sozialräumliche Analyse in einer deutschen GroßstadtHintergrund: Dass Personen mit niedrigem sozioökonomischen Status ein höheres Krankheitsrisiko haben, trifft gerade mit Blick auf schwerwiegende und chronische Erkrankungen zu. Hinsichtlich akuter notfallmedizinischer ...
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2017-11-20ZeitschriftenartikelOrigin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8 USA300 is a pandemic clonal lineage of hypervirulent, community-acquired, methicillin-resistant Staphylococcus aureus (CA-MRSA) with specific molecular characteristics. Despite its high clinical relevance, the evolutionary ...
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2017-03-01ZeitschriftenartikelEvaluating the immunogenicity and safety of a BiondVax-developed universal influenza vaccine (Multimeric-001) either as a standalone vaccine or as a primer to H5N1 influenza vaccine Phase IIb study protocolIntroduction: Influenza is a major respiratory viral infection of humans with high mortality and morbidity rates and profound economic impact. Although influenza vaccines are generally updated yearly to match the viruses ...
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2017-12-07ZeitschriftenartikelMPA Portable: A Stand-Alone Software Package for Analyzing Metaproteome Samples on the Go Metaproteomics, the mass spectrometry-based analysis of proteins from multispecies samples faces severe challenges concerning data analysis and results interpretation. To overcome these shortcomings, we here introduce ...
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2017-11-10ZeitschriftenartikelCapturing virus evolution by proteomic bioinformatics: Hunting for characteristic mutations in the hepatitis E virus genome
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2016-11-25ZeitschriftenartikelCharacterization of guinea pig T cell responses elicited after EP-assisted delivery of DNA vaccines to the skin The skin is an ideal target tissue for vaccine delivery for a number of reasons. It is highly accessible, and most importantly, enriched in professional antigen presenting cells. Possessing strong similarities to human ...
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2017-11-27ZeitschriftenartikelEvaluating the Impact of Functional Genetic Variation on HIV-1 Control Background: Previous genetic association studies of human immunodeficiency virus-1 (HIV-1) progression have focused on common human genetic variation ascertained through genome-wide genotyping. Methods: We sought ...