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Browsing by Author "Radonić, Aleksandar"
Now showing items 1-20 of 22
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2011-01-03ZeitschriftenartikelAnionic Polysaccharides From Phototrophic Microorganisms Exhibit Antiviral Activities to Vaccinia Virus Radonić, Aleksandar; Thulke, Stefanie; Achenbach, John; Kurth, Andreas; Vreemann, Anna; König, Tanja; Walter, Christian; Possinger, Kurt; Nitsche, AndreasThe aim of the present study was to characterise anti-vaccinia virus activities of anionic exopolysaccharides TK V3 isolated from cyanobacterium Arthrospira platensis and an exopolysaccharide isolated from the rhodophyt ...
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2015-04-02ZeitschriftenartikelComparative Genomic Analysis of Two Novel Sporadic Shiga Toxin-Producing Escherichia coli O104:H4 Strains Isolated 2011 in Germany Tietze, Erhard; Dabrowski, Piotr Wojtek; Prager, Rita; Radonić, Aleksandar; Fruth, Angelika; Aurass, Philipp; Nitsche, Andreas; Mielke, Martin; Flieger, AntjeA large outbreak of gastrointestinal disease occurred in 2011 in Germany which resulted in almost 4000 patients with acute gastroenteritis or hemorrhagic colitis, 855 cases of a hemolytic uremic syndrome and 53 deaths. The ...
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2015-10-15ZeitschriftenartikelComparison of 454 Ultra-Deep Sequencing and Allele-Specific Real-Time PCR with Regard to the Detection of Emerging Drug-Resistant Minor HIV-1 Variants after Antiretroviral Prophylaxis for Vertical Transmission Hauser, Andrea; Kücherer, Claudia; Kunz, Andrea; Dabrowski, Piotr Wojtek; Radonić, Aleksandar; Nitsche, Andreas; Theuring, Stefanie; Bannert, Norbert; Sewangi, Julius; Mbezi, Paulina; Dugange, Festo; Harms, Gundel; Meixenberger, KarolinBackground: Pregnant HIV-infected women were screened for the development of HIV-1 drug resistance after implementation of a triple-antiretroviral transmission prophylaxis as recommended by the WHO in 2006. The study ...
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2019-10-11ZeitschriftenartikelDendritic Cells Generated From Mops condylurus, a Likely Filovirus Reservoir Host, Are Susceptible to and Activated by Zaire Ebolavirus Infection Edenborough, Kathryn M.; Bokelmann, Marcel; Lander, Angelika; Couacy-Hymann, Emmanuel; Lechner, Johanna; Drechsel, Oliver; Renard, Bernhard Y.; Radonić, Aleksandar; Feldmann, Heinz; Kurth, Andreas; Prescott, JosephEbola virus infection of human dendritic cells (DCs) induces atypical adaptive immune responses and thereby exacerbates Ebola virus disease (EVD). Human DCs, infected with Ebola virus aberrantly express low levels of the ...
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2017-11-20ZeitschriftenartikelDevelopment and preliminary evaluation of a multiplexed amplification and next generation sequencing method for viral hemorrhagic fever diagnostics Brinkmann, Annika; Ergünay, Koray; Radonić, Aleksandar; Tufan, Zeliha Kocak; Domingo, Cristina; Nitsche, AndreasBackground: We describe the development and evaluation of a novel method for targeted amplification and Next Generation Sequencing (NGS)-based identification of viral hemorrhagic fever (VHF) agents and assess the ...
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2022-04-04ZeitschriftenartikelEffects of caloric restriction on the gut microbiome are linked with immune senescence Sbierski-Kind, Julia; Grenkowitz, Sophia; Schlickeiser, Stephan; Sandforth, Arvid; Friedrich, Marie; Kunkel, Désirée; Glauben, Rainer; Brachs, Sebastian; Mai, Knut; Thürmer, Andrea; Radonić, Aleksandar; Drechsel, Oliver; Turnbaugh, Peter J.; Bisanz, Jordan E.; Volk, Hans-Dieter; Spranger, Joachim; von Schwarzenberg, Reiner JumpertzBackground Caloric restriction can delay the development of metabolic diseases ranging from insulin resistance to type 2 diabetes and is linked to both changes in the composition and metabolic function of the gut ...
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2014-05-14ZeitschriftenartikelFatal Monkeypox in Wild-Living Sooty Mangabey, Côte d’Ivoire, 2012 Radonić, Aleksandar; Metzger, Sonja; Dabrowski, Piotr Wojtek; Couacy-Hymann, Emmanuel; Schünadel, Livia; Kurth, Andreas; Mätz-Rensing, Kerstin; Boesch, Christophe; Leendertz, Fabian; Nitsche, AndreasWe isolated a monkeypox virus from a wild-living monkey, a sooty mangabey, found dead in Taï National Park, Côte d’Ivoire, in March 2012. The whole-genome sequence obtained from this isolate and directly from clinical ...
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2020-12-24ZeitschriftenartikelFirst detection of bat-borne Issyk-Kul virus in Europe Brinkmann, Annika; Kohl, Claudia; Radonić, Aleksandar; Dabrowski, Piotr Wojtek; Mühldorfer, Kristin; Nitsche, Andreas; Wibbelt, Gudrun; Kurth, AndreasBats have been gaining attention as potential reservoir hosts of numerous viruses pathogenic to animals and man. Issyk-Kul virus, a member of the family Nairoviridae, was first isolated in the 1970s from vespertilionid ...
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2015-09-24ZeitschriftenartikelFirst Draft Genome Sequence of Balamuthia mandrillaris, the Causative Agent of Amoebic Encephalitis Detering, H.; Aebischer, Toni; Dabrowski, Piotr Wojtek; Radonić, Aleksandar; Nitsche, Andreas; Renard, Bernhard Y.; Kiderlen, AlbrechtThe free-living amoeba Balamuthia mandrillaris is a rare but highly lethal agent of amoebic encephalitis in humans and many other mammalian species. Here, we announce the first draft genome sequence of the original 1990 ...
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2019-11-06ZeitschriftenartikelGenetic Diversity and Spatial Segregation of Francisella tularensis Subspecies holarctica in Germany Appelt, Sandra; Köppen, Kristin; Radonić, Aleksandar; Drechsel, Oliver; Jacob, Daniela; Grunow, Roland; Heuner, KlausFrancisella tularensis is an intracellular pleomorphic bacterium and the causative agent of tularemia, a zoonotic disease with a wide host range. Among the F. tularensis subspecies, especially F. tularensis subsp. holarctica ...
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2011-11-30ZeitschriftenartikelGenome analysis of bat adenovirus 2: Indications of interspecies transmission Kohl, Claudia; Vidovszky, Márton Z.; Mühldorfer, Kristin; Dabrowski, Piotr Wojtek; Radonić, Aleksandar; Nitsche, Andreas; Wibbelt, Gudrun; Kurth, Andreas; Harrach, BalázsThe genome of bat adenovirus 2 was sequenced and analyzed. It is similar in size (31,616 bp) to the genomes of bat adenovirus 3 and canine adenoviruses 1 and 2. These four viruses are monophyletic and share an identical ...
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2013-12-03ZeitschriftenartikelGenome-Wide Comparison of Cowpox Viruses Reveals a New Clade Related to Variola Virus Dabrowski, Piotr Wojtek; Radonić, Aleksandar; Kurth, Andreas; Nitsche, AndreasZoonotic infections caused by several orthopoxviruses (OPV) like monkeypox virus or vaccinia virus have a significant impact on human health. In Europe, the number of diagnosed infections with cowpox viruses (CPXV) is ...
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2014-12-30ZeitschriftenartikelInvestigating the zoonotic origin of the West African Ebola epidemic Saéz, Almudena Marí; Weiss, Sabrina; Nowak, Kathrin; Lapeyre, Vincent; Zimmermann, Fee; Düx, Ariane; Kühl, Hjalmar S.; Kaba, Moussa; Regnaut, Sebastien; Merkel, Kevin; Sachse, Andreas; Thiesen, Ulla; Villányi, Lili; Boesch, Christophe; Dabrowski, Piotr Wojtek; Radonić, Aleksandar; Nitsche, Andreas; Leendertz, Siv Aina J.; Petterson, Stefan; Becker, Stephan; Schaade, Lars; Fahr, Jakob; Gogarten, Jan F.; Calvignac-Spencer, Sébastien; Leendertz, FabianThe severe Ebola virus disease epidemic occurring in West Africa stems from a single zoonotic transmission event to a 2‐year‐old boy in Meliandou, Guinea. We investigated the zoonotic origins of the epidemic using wildlife ...
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2012-08-14ZeitschriftenartikelIsolation and characterization of three Mammalian orthoreoviruses from European bats. Kohl, Claudia; Lesnik, René; Brinkmann, Annika; Ebinger, Arnt; Radonić, Aleksandar; Nitsche, Andreas; Mühldorfer, Kristin; Wibbelt, Gudrun; Kurth, AndreasIn recent years novel human respiratory disease agents have been described in South East Asia and Australia. The causative pathogens were classified as pteropine orthoreoviruses with strong phylogenetic relationship to ...
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2019-03-15ZeitschriftenartikelMolecular identification of the source of an uncommon tularaemia outbreak, Germany, autumn 2016 Jacob, Daniela; Köppen, Kristin; Radonić, Aleksandar; Haldemann, Berit; Zanger, Philipp; Heuner, Klaus; Grunow, RolandBackground In 2016, an uncommon outbreak of oropharyngeal tularaemia involving six human cases occurred in Germany, caused by drinking contaminated fresh must after a grape harvest. Aim We describe the details of ...
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2013-06-01ZeitschriftenartikelNovel Mycobacterium tuberculosis Complex Isolate from a Wild Chimpanzee Coscolla, Mireia; Lewin, Astrid; Metzger, Sonja; Mätz-Rennsing, Kerstin; Calvignac-Spencer, Sébastien; Nitsche, Andreas; Dabrowski, Piotr Wojtek; Radonić, Aleksandar; Niemann, Stefan; Parkhill, Julian; Couacy-Hymann, Emmanuel; Feldman, Julia; Comas, Iñaki; Boesch, Christophe; Gagneux, Sebastien; Leendertz, FabianTuberculosis (TB) is caused by gram-positive bacteria known as the Mycobacterium tuberculosis complex (MTBC). MTBC include several human-associated lineages and several variants adapted to domestic and, more rarely, wild ...
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2014-12-15ZeitschriftenartikelProtocol for Metagenomic Virus Detection in Clinical Specimens Kohl, Claudia; Brinkmann, Annika; Dabrowski, Piotr Wojtek; Radonić, Aleksandar; Nitsche, Andreas; Kurth, AndreasSixty percent of emerging viruses have a zoonotic origin, making transmission from animals a major threat to public health. Prompt identification and analysis of these pathogens are indispensable to taking action toward ...
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2011-11-09ZeitschriftenartikelRNA interference inhibits replication of tick-borne encephalitis virus in vitro. Achazi, Katharina; Patel, Pranav; Paliwal, Ravish; Radonić, Aleksandar; Niedrig, Matthias; Mantke, Oliver DonosoEach year, up to 10,000 cases of infections with the flavivirus tick-borne encephalitis (TBE) virus that affect the central nervous system are reported in Europe and Asia. Due to the potentially severe adverse effects of ...
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2018-08-15ZeitschriftenartikelSilent Witness: Dual-Species Transcriptomics Reveals Epithelial Immunological Quiescence to Helminth Larval Encounter and Fostered Larval Development Ebner, Friederike; Kuhring, Mathias; Radonić, Aleksandar; Midha, Ankur; Renard, Bernhard Y.; Hartmann, SusanneGastrointestinal nematodes are among the most prevalent parasites infecting humans and livestock worldwide. Infective larvae of the soil-transmitted nematode Ascaris spp. enter the host and start tissue migration by crossing ...
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2021-04-01ZeitschriftenartikelThe virome ofGerman bats: comparing virus discovery approaches Kohl, Claudia; Brinkmann, Annika; Radonić, Aleksandar; Dabrowski, Piotr Wojtek; Mühldorfer, Kristin; Nitsche, Andreas; Wibbelt, Gudrun; Kurth, AndreasBats are known to be reservoirs of several highly pathogenic viruses. Hence, the interest in bat virus discovery has been increasing rapidly over the last decade. So far, most studies have focused on a single type of virus ...