Auflistung nach Titel
Anzeige der Publikationen 3764-3783 von 11519
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2017-06-30ZeitschriftenartikelEstablishing an ICD-10 code based SARI-surveillance in Germany – description of the system and first results from five recent influenza seasons Background: Syndromic surveillance of severe acute respiratory infections (SARI) is important to assess seriousness of disease as recommended by WHO for influenza. In 2015 the Robert Koch Institute (RKI) started to ...
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2014-01-01MasterarbeitEstablishment and evaluation of a feline foamy virus subviral particle-based vaccine strategy for induction of neutralizing antibodies against HIV-1 35 million people died due to the acquired immunodeficiency syndrome (AIDS) since the outbreak of the HIV pandemic. Despite intensive research, developing an immu-nogen to induce broadly neutralizing antibodies (bnAbs) ...
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2016-07-01MasterarbeitEstablishment of a method for the detection of proviral cDNA of HERV-K(HML-2) Humane endogene Retroviren (HERVs) konnten viele Millionen Jahre lang Proviren in die menschliche Keimbahn integrieren. Jedoch führten im Laufe der Jahre Mutationen, Deletionen und Rekombinationen zu deren Inaktivierung. ...
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2021-10-27ZeitschriftenartikelEstablishment of a Publicly Available Core Genome Multilocus Sequence Typing Scheme for Clostridium perfringens Clostridium perfringens is a spore-forming anaerobic pathogen responsible for a variety of histotoxic and intestinal infections in humans and animals. High-resolution genotyping aiming to identify bacteria at strain level ...
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2017-02-09ZeitschriftenartikelEstablishment of a voluntary electronic Chlamydia trachomatis laboratory surveillance system in Germany, 2008 to 2014 Chlamydia trachomatis (CT) infections are not reportable in Germany and limited data on prevalence are available. CT screening has been offered free of charge to pregnant women since 1995 and to all women under 25 years ...
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2010-06-11ZeitschriftenartikelEstimated and measured BMI and self-perceived body image of adolescents in Germany: part 1 - general implications for correcting prevalence estimations of overweight and obesity. Objective: This study examines the degree of divergence between BMI calculated from subjective assessments and BMI calculated from measured height and weight as a function of gender and body image. Methods: In the German ...
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2013-07-16ZeitschriftenartikelEstimates of Excess Medically Attended Acute Respiratory Infections in Periods of Seasonal and Pandemic Influenza in Germany from 2001/02 to 2010/11 Background: The number of patients seeking health care is a central indicator that may serve several different purposes: (1) as a proxy for the impact on the burden of the primary care system; (2) as a starting point ...
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2021-06-29ZeitschriftenartikelEstimates of Toxoplasmosis Incidence Based on Healthcare Claims Data, Germany, 2011–2016 Toxoplasmosis is a zoonotic infection contracted through Toxoplasma gondii–contaminated food, soil, or water. Seroprevalence in Germany is high, but estimates of disease incidence are scarce. We investigated incidences for ...
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2019-04-25ZeitschriftenartikelEstimating age-specific vaccine effectiveness using data from a large measles outbreak in Berlin, Germany, 2014/15: evidence for waning immunity Background Measles elimination is based on 95% coverage with two doses of a measles-containing vaccine (MCV2), high vaccine effectiveness (VE) and life-long vaccine-induced immunity. Longitudinal analysis of antibody ...
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2009-06-11ZeitschriftenartikelEstimating the regional distribution of men who have sex with men (MSM) based on Internet surveys Background: Measurement of prevalence and incidence of infections in a hard to reach population like men who have sex with men (MSM) is hampered by its unknown size and regional distribution. Population-based surveys ...
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2013-10-03ZeitschriftenartikelEstimating the size of the MSM populations for 38 European countries by calculating the survey-surveillance discrepancies (SSD) between self-reported new HIV diagnoses from the European MSM internet survey (EMIS) and surveillance-reported HIV diagnoses among MSM in 2009 Background: Comparison of rates of newly diagnosed HIV infections among MSM across countries is challenging for a variety of reasons, including the unknown size of MSM populations. In this paper we propose a method of ...
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2014-03-01ZeitschriftenartikelEstimating the under-reporting of norovirus illness in Germany utilizing enhanced awareness of diarrhoea during a large outbreak of Shiga toxin-producing E. coli O104:H4 in 2011 – a time series analysis Background: Laboratory-confirmed norovirus illness is reportable in Germany since 2001. Reported case numbers are known to be undercounts, and a valid estimate of the actual incidence in Germany does not exist. An ...
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2014-08-22ZeitschriftenartikelEstimating Trends in the Proportion of Transmitted and Acquired HIV Drug Resistance in a Long Term Observational Cohort in Germany Objective: We assessed trends in the proportion of transmitted (TDR) and acquired (ADR) HIV drug resistance and associated mutations between 2001 and 2011 in the German ClinSurv-HIV Drug Resistance Study. Method: ...
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2016-07-29ZeitschriftenartikelEstimating true incidence of O157 and non-O157 Shiga toxin-producing Escherichia coli illness in Germany based on notification data of haemolytic uraemic syndrome Shiga toxin-producing Escherichia coli (STEC) is an important cause of gastroenteritis (GE) and haemolytic uraemic syndrome (HUS). Incidence of STEC illness is largely underestimated in notification data, particularly of ...
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2012-04-26ZeitschriftenartikelEstimating vaccination coverage in the absence of immunisation registers – the German experience Immunisation registers are regarded as an appropriate solution to measure vaccination coverage on a population level. In Germany, a decentralised healthcare system and data protection regulations constrain such an approach. ...
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2016-11-18ZeitschriftenartikelEstimation of influenza-attributable medically attended acute respiratory illness by influenza type/subtype and age, Germany, 2001/02–2014/15 Background: The total burden of influenza in primary care is difficult to assess. The case definition of medically attended “acute respiratory infection” (MAARI) in the German physician sentinel is sensitive; however, ...
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2019-07-24ZeitschriftenartikelEstimation of influenza‐ and respiratory syncytial virus‐attributable medically attended acute respiratory infections in Germany, 2010/11‐2017/18 Background The burden of influenza in primary care is difficult to assess, since most patients with symptoms of a respiratory infection are not tested. The case definition of “medically attended acute respiratory infection” ...
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2014-12-01MasterarbeitEtablierung einer Komplett-Genom-RT-PCR und Next-Generation-Sequencing für full-length Genome von HIV-1 Die globale HIV-1 Epidemie wird durch die geografisch unterschiedliche Verbreitung von 9 HIV-1 Subtypen (A-D, F-H, J, K) und derzeit 72 zirkulierenden rekombinanten Formen (CRF) charakterisiert. Die genetische Diversität ...
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2019-01-28BachelorarbeitEtablierung einer subtypgenerischen HIV-1 envelope PCR zur Bestimmung des Korezeptor-Tropismus aus Plasma und dried fluid spots Die Entwicklung antiretroviraler Medikamente förderte in den letzten Jahren sowohl die Prävention von HIV als auch die Verbesserung des Krankheitsbildes infizierter Patienten. Im Angesicht, der sich entwickelnden Resistenzen ...
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2015-01-01BachelorarbeitEtablierung eines sensitiven quantitativen Nachweises proviraler HIV-1 – DNA zur Lokalisation der HIV-1 - Reservoire Auch im Jahr 2013 sind noch ca. 1,5 Millionen Menschen durch HIV/AIDS gestorben. Seit Jahrzehnten wird nun schon an der Bekämpfung der HI-Viren geforscht und gearbeitet. Der-zeit klinisch angewandte Antiretrovirale Therapien ...