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Anzeige der Publikationen 1181-1200 von 11528
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2018-08-01ZeitschriftenartikelBotulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58–K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities In the recent past, about 40 botulinum neurotoxin (BoNT) subtypes belonging to serotypes A, B, E, and F pathogenic to humans were identified among hundreds of independent isolates. BoNTs are the etiological factors of ...
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2016-05-17ZeitschriftenartikelBotulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin Botulinum neurotoxins (BoNTs) exhibit extraordinary potency due to their exquisite neurospecificity, which is achieved by dual binding to complex polysialo-gangliosides and synaptic vesicle proteins. The luminal domain 4 ...
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2009-12-21ZeitschriftenartikelBreaking the waves: modelling the potential impact of Public Health measures to defer the epidemic peak of novel influenza A/H1N1 Background: On June 11, 2009, the World Health Organization declared phase 6 of the novel influenza A/H1N1 pandemic. Although by the end of September 2009, the novel virus had been reported from all continents, the impact ...
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2009-11-30ZeitschriftenartikelBreakthrough zygomycosis on posaconazole prophylaxis after allogeneic stem cell transplantation. Antifungal prophylaxis with posaconazole (POS) has been shown to decrease the mortality associated with invasive fungal infections in high-risk patients. We report on a patient, with severe graft-versus-host disease after ...
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2019-11-01ZeitschriftenartikelBreast cancer incidence and mortality before and after implementation of the German mammography screening program Effective population‐based mammography screening should impact breast cancer (BC) incidence, age and stage‐specific incidence and BC mortality. We aim to investigate such effects in a time period of 10 years after ...
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2014-05-01ZeitschriftenartikelBreast-feeding and maternal risk of type 2 diabetes: a prospective study and meta-analysis Aims/hypothesis: We aimed to examine the association between breast-feeding and maternal risk of type 2 diabetes and to investigate whether this association is mediated by anthropometric and biochemical factors. Methods: ...
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2016-12-14ZeitschriftenartikelBreastfeeding monitoring in Germany - What contribution can the data from KiGGS provide? A continuous breastfeeding monitoring is essential as it enables reports on changes in breastfeeding behaviour. The German Health Interview and Examination Survey for Children and Adolescents (KiGGS), which is conducted ...
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2016-09-16ZeitschriftenartikelBrincidofovir clearance of acyclovir-resistant herpes simplex virus-1 and adenovirus infection after stem cell transplantation Infections with adenovirus (AdV) and herpesviruses can result in considerable morbidity and mortality in pediatric hematopoietic stem cell transplant (SCT) recipients. Herpes simplex virus (HSV) reactivations are usually ...
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2018-10-22ZeitschriftenartikelBringing together what belongs together: Optimizing murine infection models by using mouse-adapted Staphylococcus aureus strains Staphylococcus (S.) aureus is a leading cause of bacterial infection world-wide, and currently no vaccine is available for humans. Vaccine development relies heavily on clinically relevant infection models. However, the ...
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2021-01-17ZeitschriftenartikelBromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein The new coronavirus, SARS-CoV-2, transmits rapidly from human-to-human resulting in the ongoing pandemic. SARS-CoV-2 infects angiotensin-converting enzyme 2 (ACE-2) expressing lung, heart, kidney, intestine, gall bladder, ...
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1997-02-01ZeitschriftenartikelBrucellose-Erkrankungen in Deutschland
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2016-08-04ZeitschriftenartikelBrucellosis in a refugee who migrated from Syria to Germany and lessons learnt, 2016 A teenage woman migrating from Syria arrived in May 2015 in Germany. She gave birth to a healthy child in early 2016, but became febrile shortly after delivery. Blood cultures revealed Brucella melitensis. In retrospect, ...
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2013-06-01ZeitschriftenartikelBSE-associated Prion-Amyloid Cardiomyopathy in Primates Prion amyloidosis occurred in the heart of 1 of 3 macaques intraperitoneally inoculated with bovine spongiform encephalopathy prions. This macaque had a remarkably long duration of disease and signs of cardiac distress. ...
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2021-04-20ZeitschriftenartikelBugs That Can Resist Antibiotics but Not Men: Gender-Specific Differences in Notified Infections and Colonisations in Germany, 2010–2019 Data from surveillance networks show that men have a higher incidence rate of infections with anti-microbial-resistant (AMR) pathogens than women. We systematically analysed data of infections and colonisations with AMR ...
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2000-05-15DatensatzBundes-Gesundheitssurvey 1998 (BGS98) Der Bundes-Gesundheitssurvey 1998 (BGS98) wurde von 1997 bis 1999 vom Robert Koch-Institut durchgeführt. Dabei wurden Gesundheitsdaten von 7.124 Personen zwischen 18 und 79 Jahren aus 120 Städten und Gemeinden in ganz ...
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2003-06-11Berichte und sonstige TexteBundes-Gesundheitssurvey: Alkohol Im vorliegenden Bericht wird das Alkoholkonsumverhalten der deutschen Wohnbevölkerung unter Berücksichtigung der »tolerierbaren oberen Alkoholzufuhrmengen« (TOAM) untersucht. Analysegrundlage sind die Daten des ...
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2003-11-14Berichte und sonstige TexteBundes-Gesundheitssurvey: Arzneimittelgebrauch Dieser Bericht beschreibt u.a. das Arzneimittelverbrauchs- bzw. Verordnungsgeschehen in der Bundesrepublik Deutschland und leistet einen wichtigen epidemiologischen Beitrag zur Arzneimittelsicherheit. Selbstangaben zur ...
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2003-01-01Berichte und sonstige TexteBundes-Gesundheitssurvey: Bausteine der Gesundheitssurveillance in Deutschland Neben ausgewählten Ergebnissen aus den einzelnen Modulen des BGS98 werden seine Zielstellung und Methodik erläutert. Dieses Heft bildet den Auftakt einer Serie von Publikationen, in denen zukünftig Ergebnisse aus den Surveys ...
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2003-02-27Berichte und sonstige TexteBundes-Gesundheitssurvey: Körperliche Aktivität Dieses Heft gibt einen Überblick über das körperliche Aktivitätsverhalten in Deutschland anhand des Bundes-Gesundheitssurveys 1998.
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2006-06-07Berichte und sonstige TexteBundes-Gesundheitssurvey: Soziale Unterschiede im Rauchverhalten und in der Passivrauchbelastung in Deutschland Der Tabakkonsum stellt am Anfang des 21. Jahrhunderts das bedeutendste einzelne Gesundheitsrisiko in den entwickelten Industrienationen dar. Der vorliegende GBE-Beitrag befasst sich mit der Frage, welche sozialen Unterschiede ...