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Anzeige der Publikationen 4096-4115 von 11520
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2019-06-25ZeitschriftenartikelGeneralization of the small-world effect on a model approaching the Erdős–Rényi random graph The famous Watts–Strogatz (WS) small-world network model does not approach the Erdős–Rényi (ER) random graph model in the limit of total randomization which can lead to confusion and complicates certain analyses. In this ...
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2011-04-28ZeitschriftenartikelGeneration and characterisation of monoclonal antibodies against influenza virus A, subtype H5N1 The emergence of highly pathogenic avian influenza A virus (HPAIV) subtype H5N1 in 1997 has since resulted in large outbreaks in poultry and in transmission from poultry to humans, mostly in southeast Asia, but also in ...
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2015-11-26ZeitschriftenartikelGeneration and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test The detection and identification of botulinum neurotoxins (BoNT) is complex due to the existence of seven serotypes, derived mosaic toxins and more than 40 subtypes. Expert laboratories currently use different technical ...
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2017-07-14ZeitschriftenartikelGeneric amplification and next generation sequencing reveal Crimean-Congo hemorrhagic fever virus AP92-like strain and distinct tick phleboviruses in Anatolia, Turkey Background: Ticks are involved with the transmission of several viruses with significant health impact. As incidences of tick-borne viral infections are rising, several novel and divergent tick- associated viruses have ...
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2021-09-21ZeitschriftenartikelGenetic diversification of persistent Mycobacterium abscessus within cystic fibrosis patients Mycobacterium (M.) abscessus infections in Cystic Fibrosis (CF) patients cause a deterioration of lung function. Treatment of these multidrug-resistant pathogens is associated with severe side-effects, while frequently ...
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2017-02-01ZeitschriftenartikelGenetic Diversity and New Lineages of Dengue Virus Serotypes 3 and 4 in Returning Travelers, Germany, 2006–2015 During 2006–2015, we analyzed 70 dengue virus (DENV) strains isolated from febrile travelers returning to Germany. High genetic diversity, including multiple co-circulating DENV lineages and emerging new lineages of DENV-3 ...
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2019-11-06ZeitschriftenartikelGenetic Diversity and Spatial Segregation of Francisella tularensis Subspecies holarctica in Germany Francisella tularensis is an intracellular pleomorphic bacterium and the causative agent of tularemia, a zoonotic disease with a wide host range. Among the F. tularensis subspecies, especially F. tularensis subsp. holarctica ...
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2022-12-21ZeitschriftenartikelGenetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia The effectiveness of metronidazole against the tetraploid intestinal parasite Giardia lamblia is dependent on its activation/inactivation within the cytoplasm. There are several activating enzymes, including pyruvate ...
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2021-03-24ZeitschriftenartikelGenetic Diversity of Enteric Viruses in Children under Five Years Old in Gabon Enteric viruses are the leading cause of diarrhea in children globally. Identifying viral agents and understanding their genetic diversity could help to develop effective preventive measures. This study aimed to determine ...
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2020-12-18ZeitschriftenartikelGenetic Diversity of the Flavohemoprotein Gene of Giardia lamblia: Evidence for High Allelic Heterozygosity and Copy Number Variation Purpose: The flavohemoprotein (gFlHb) in Giardia plays an important role in managing nitrosative and oxidative stress, and potentially also in virulence and nitroimidazole drug tolerance. The aim of this study was to analyze ...
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2012-03-23ZeitschriftenartikelGenetic Evidence of Functional Ficolin-2 Haplotype as Susceptibility Factor in Cutaneous Leishmaniasis Background: Ficolin-2 coded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity. In this study, we analyzed five functional polymorphisms of the FCN2 gene for their possible association ...
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2015-10-05ZeitschriftenartikelGenetic identification of cytomegaloviruses in a rural population of Côte d’Ivoire Background: Cytomegaloviruses (CMVs) are herpesviruses that infect many mammalian species, including humans. Infection generally passes undetected, but the virus can cause serious disease in individuals with impaired ...
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2023-02-01Berichte und sonstige TexteGenetic Organization of Acquired Antimicrobial Resistance Genes and Detection of Resistance-Mediating Mutations in a Gallibacterium anatis Isolate from a Calf Suffering from a Respiratory Tract Infection Gallibacterium (G.) anatis isolates associated with respiratory diseases in calves and har- boring acquired antimicrobial resistance genes have been described in Belgium. The aim of this study was to analyze the genetic ...
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2009-04-22ZeitschriftenartikelGenetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007. The variability between respiratory syncytial virus (RSV) strains is one of the features of RSV infections that might contribute to the ability of the virus to infect people repeatedly and cause yearly outbreaks. To study ...
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2018-01-14ZeitschriftenartikelGenetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection Aim: To investigate possible effects of IRF5 polymorphisms in the 3’ UTR region of the IFR5 locus on susceptibility to hepatitis B virus (HBV) infection and progression of liver diseases among clinically classified ...
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2019-05-10ZeitschriftenartikelGenetic variation in metronidazole metabolism and oxidative stress pathways in clinical Giardia lamblia assemblage A and B isolates Purpose: Treatment-refractory Giardia cases have increased rapidly within the last decade. No markers of resistance nor a standardized susceptibility test have been established yet, but several enzymes and their pathways ...
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2019-11-15ZeitschriftenartikelGenetic, Epigenetic and Phenotypic Diversity of Four Bacillus velezensis Strains Used for Plant Protection or as Probiotics Bacillus velezensis strains are applied as ecologically safe biopesticides, plant growth promoting rhizobacteria (PGPR), and in veterinary probiotics. They are abundant in various environments including soil, plants, marine ...
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2005-01-24ZeitschriftenartikelGenetical and functional investigation of fliC genes encoding flagellar serotype H4 in wildtype strains of Escherichia coli and in a laboratory E. coli K-12 strain expressing flagellar antigen type H48 Background: Serotyping of O-(lipopolysaccharide) and H-(flagellar) antigens is a wideley used method for identification of pathogenic strains and clones of Escherichia coli. At present, 176 O- and 53 H-antigens are ...
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2019-01Berichte und sonstige TexteGenetische Beratung und Inanspruchnahme GenBIn2 Die genetische Beratung wird durch das Gendiagnostikgesetz und die Richtlinie über die Anforderungen an die Qualifikation zur und Inhalte der genetischen Beratung der Gendiagnostik-Kommission beim Robert Koch-Institut ...
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2015-01-14ZeitschriftenartikelGenetische Information und Prävention