Browsing by Title
Now showing items 4432-4451 of 12214
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2021-01-19ZeitschriftenartikelGenome-Based Analyses of Fitness Effects and Compensatory Changes Associated with Acquisition of blaCMY-, blaCTX-M-, and blaOXA-48/VIM-1-Containing Plasmids in Escherichia coli Background: Resistance plasmids are under selective conditions beneficial for the bacterial host, but in the absence of selective pressure, this carriage may cause fitness costs. Compensation of this fitness burden is ...
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2018-05-02ZeitschriftenartikelGenome-based analysis of Carbapenemase-producing Klebsiella pneumoniae isolates from German hospital patients, 2008-2014 Background By using whole genome sequence data we aimed at describing a population snapshot of carbapenemase-producing K. pneumoniae isolated from hospitalized patients in Germany between 2008 and 2014. Methods We ...
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2021-05-08ZeitschriftenartikelGenome-Based Analysis of Klebsiella spp. Isolates from Animals and Food Products in Germany, 2013–2017 The increase in infections with multidrug-resistant and virulent Klebsiella pneumoniae (K. pneumoniae) strains poses a serious threat to public health. However, environmental reservoirs and routes of transmission for ...
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2020-03-09ZeitschriftenartikelGenome-based Salmonella serotyping as the new gold standard Salmonella enterica is the second most reported bacterial cause of food-borne infections in Europe. Therefore molecular surveillance activities based on pathogen subtyping are an important measure of controlling Salmonellosis ...
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2021-04-22ZeitschriftenartikelGenome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide ...
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2021-02-15ZeitschriftenartikelGenome-Wide Association Studies for the Detection of Genetic Variants Associated With Daptomycin and Ceftaroline Resistance in Staphylococcus aureus Background: As next generation sequencing (NGS) technologies have experienced a rapid development over the last decade, the investigation of the bacterial genetic architecture reveals a high potential to dissect causal ...
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2013-12-03ZeitschriftenartikelGenome-Wide Comparison of Cowpox Viruses Reveals a New Clade Related to Variola Virus Zoonotic infections caused by several orthopoxviruses (OPV) like monkeypox virus or vaccinia virus have a significant impact on human health. In Europe, the number of diagnosed infections with cowpox viruses (CPXV) is ...
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2021-05-14ZeitschriftenartikelGenome‑wide insights into population structure and host specifcity of Campylobacter jejuni The zoonotic pathogen Campylobacter jejuni is among the leading causes of foodborne diseases worldwide. While C. jejuni colonises many wild animals and livestock, persistence mechanisms enabling the bacterium to adapt to ...
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2022-08-03ZeitschriftenartikelGenomic Analysis of Acinetobacter baumannii Isolates Carrying OXA-23 and OXA-58 Genes from Animals Reveals ST1 and ST25 as Major Clonal Lineages Acinetobacter baumannii is increasingly being recognized as a relevant pathogen for animals with a putative zoonotic impact. This study aimed at identifying and characterizing carbapenemase-producing A. baumannii from ...
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2022-02-22ZeitschriftenartikelGenomic analysis of the zoonotic ST73 lineage containing avian and human extraintestinal pathogenic Escherichia coli (ExPEC) Extraintestinal pathogenic Escherichia coli (ExPEC) is a globally distributed pathogen, with uropathogenic E. coli (UPEC) and sepsis-associated E. coli (SEPEC) pathotypes particularly involved in human and companion animal ...
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2019-12-03ZeitschriftenartikelGenomic and Functional Characterization of Poultry Escherichia coli From India Revealed Diverse Extended-Spectrum β-Lactamase-Producing Lineages With Shared Virulence Profiles Extended-spectrum β-lactamases (ESBLs) form the most important resistance determinants prevalent worldwide. Data on ESBL-producing Escherichia coli from poultry and livestock are scarce in India. We present data on the ...
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2022-05-02ZeitschriftenartikelGenomic and Phenotypic Characterization of Clostridium botulinum Isolates from an Infant Botulism Case Suggests Adaptation Signatures to the Gut In early life, the immature human gut microbiota is prone to colonization by pathogens that are usually outcompeted by mature microbiota in the adult gut. Colonization and neurotoxin production by a vegetative Clostridium ...
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2021-04-01ZeitschriftenartikelGenomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-Producing Escherichia coli Strains From Healthy Food Animals Across Europe The role of livestock animals as a putative source of ESBL/pAmpC E. coli for humans is a central issue of research. In a large-scale pan-European surveillance, 2,993 commensal Escherichia spp. isolates were recovered from ...
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2011-07-14ZeitschriftenartikelGenomic expression libraries for the identification of cross-reactive orthopoxvirus antigens. Increasing numbers of human cowpox virus infections that are being observed and that particularly affect young nonvaccinated persons have renewed interest in this zoonotic disease. Usually causing a self-limiting local ...
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2022-05-03ZeitschriftenartikelGenomic Sequencing and Analysis of a Novel Human Cowpox Virus With Mosaic Sequences From North America and Old World Orthopoxvirus Orthopoxviruses (OPXVs) not only infect their natural hosts, but some OPXVs can also cause disease in humans. Previously, we partially characterized an OPXV isolated from an 18-year-old male living in Northern Norway. ...
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2017-03-16ZeitschriftenartikelGenomsequenzdaten von Tuberkulosebakterien für die Tuberkuloseüberwachung – Anforderungen und Perspektiven Bericht über einen Workshop am Robert Koch-Institut
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2016-09-01MasterarbeitGenotypische Bestimmung des HIV-1 Ko-Rezeptorgebrauchs bei HIV-Neudiagnosen zur Unterscheidung von kürzlich erworbenen und chronischen Infektionen Für einen effizienten Viruseintritt bindet das Humane Immundefizienzvirus (HIV) über das Hüllprotein gp120 den immunogenen Rezeptor CD4 sowie den Ko-Rezeptor CCR5 oder CXCR4 auf Immunzellen. Entsprechend des Ko-Rezeptorgebrauchs ...
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2000-02-01ZeitschriftenartikelGentechnisch veränderte Pflanzen der “Zweiten und Dritten Generation”: Was können wir erwarten? Die gentechnisch veränderten Pflanzen werden aufgrund ihrer gentechnischen Veränderungen klassifiziert und fünf verschiedenen Anwendungsgebieten zugeordnet. Während die gentechnisch veränderten Pflanzen des Anwendungsgebietes ...
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2022-03-17ZeitschriftenartikelGeo-Spatial Characteristics of 567 Places of Tick-Borne Encephalitis Infection in Southern Germany, 2018–2020 Tick-borne encephalitis (TBE) is a growing public health problem with increasing incidence and expanding risk areas. Improved prevention requires better understanding of the spatial distribution and ecological determinants ...
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2022-02-04ZeitschriftenartikelGeographical differences of carbapenem non-susceptible Enterobacterales and Acinetobacter spp. in Germany from 2017 to 2019 Background Since May 2016, infection and colonisation with carbapenem non-susceptible Acinetobacter spp. (CRA) and Enterobacterales (CRE) have to be notified to health authorities in Germany. The aim of our study was ...