Browsing by Title
Now showing items 81-100 of 11425
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2022-05-25ZeitschriftenartikelA Federated and Distributed Data Management Infrastructure to Enable Public Health Surveillance from Intensive Care Unit Data The Robert Koch Institute (RKI) monitors the actual number of COVID-19 patients requiring intensive care from aggregated data reported by hospitals in Germany. So far, there is no infrastructure to make use of individual ...
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2016-09-29ZeitschriftenartikelA Field-Deployable Reverse Transcription Recombinase Polymerase Amplification Assay for Rapid Detection of the Chikungunya Virus Background: Chikungunya virus (CHIKV) is a mosquito-borne virus currently transmitted in about 60 countries. CHIKV causes acute flu-like symptoms and in many cases prolonged musculoskeletal and joint pain. Detection of ...
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2016-01-12ZeitschriftenartikelA Follow-Up of the Multicenter Collaborative Study on HIV-1 Drug Resistance and Tropism Testing Using 454 Ultra Deep Pyrosequencing Background: Ultra deep sequencing is of increasing use not only in research but also in diagnostics. For implementation of ultra deep sequencing assays in clinical laboratories for routine diagnostics, intra- and ...
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2013-09-12ZeitschriftenartikelA Food Handler-Associated, Foodborne Norovirus GII.4 Sydney 2012-Outbreak Following a Wedding Dinner, Austria, October 2012 On October 12, 2012, the provincial public health directorate of Salzburg reported a suspected norovirus (NV) outbreak among guests of a wedding-reception. The investigation aimed to confirm the causative agent, to identify ...
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2015-04-09ZeitschriftenartikelA Gateway-Based System for Fast Evaluation of Protein-Protein Interactions in Bacteria Protein-protein interactions are important layers of regulation in all kingdoms of life. Identification and characterization of these interactions is one challenging task of the post-genomic era and crucial for understanding ...
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2013-01-08ZeitschriftenartikelA genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic The widespread use of antibiotics in association with high-density clinical care has driven the emergence of drug-resistant bacteria that are adapted to thrive in hospitalized patients. Of particular concern are globally ...
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2022-09StudienarbeitA health economic evaluation of prostate-specific antigen-based risk-stratified prostate cancer screening strategies in Germany Prostate cancer (PCa) screening remains a controversial topic. The value of population-based screening in reducing premature deaths remains unclear, primarily due to over-diagnosis and overtreatments. However, with an ...
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2017-01-12ZeitschriftenartikelA joint cross-border investigation of a cluster of multidrug-resistant tuberculosis in Austria, Romania and Germany in 2014 using classic, genotyping and whole genome sequencing methods: lessons learnt Molecular surveillance of multidrug-resistant tuberculosis (MDR-TB) using 24-loci MIRU-VNTR in the European Union suggests the occurrence of international transmission. In early 2014, Austria detected a molecular MDR-TB ...
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2020-12-09ZeitschriftenartikelA Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition Background Antibiotic-resistant Klebsiella pneumoniae are a major cause of hospital- and community-acquired infections, including sepsis, liver abscess, and pneumonia, driven mainly by the emergence of successful high-risk ...
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2017-10-31ZeitschriftenartikelA large proportion of people who inject drugs are susceptible to hepatitis B: Results from a bio-behavioural study in eight German cities Background: People who inject drugs (PWID) are at high risk of hepatitis B virus (HBV) infection by sharing needles and drug use paraphernalia. In Germany, no routine surveillance of HBV prevalence and vaccination ...
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2018-05-02ZeitschriftenartikelA lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency The exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of synaptic vesicle proteins embedded in the presynaptic membrane. ...
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2019-01-16ZeitschriftenartikelA Listeria monocytogenes ST2 clone lacking chitinase ChiB from an outbreak of non-invasive gastroenteritis An outbreak with a remarkable Listeria monocytogenes clone causing 163 cases of non-invasive listeriosis occurred in Germany in 2015. Core genome multi locus sequence typing grouped non-invasive outbreak isolates and ...
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2010-03-23ZeitschriftenartikelA longitudinal study of urinary dipstick parameters in wild chimpanzees (Pan troglodytes verus) in Côte d'ivoire We performed 796 dip-stick tests on urine from 100 wild West African chimpanzees (Pan troglodytes verus) from 4 habituated groups in the tropical rain forest of Taï National Park, Cote d'Ivoire, to establish reference ...
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2016-01-22ZeitschriftenartikelA Look into the Melting Pot: The mecC-Harboring Region Is a Recombination Hot Spot in Staphylococcus stepanovicii Introduction: Horizontal gene transfer (HGT) is an important driver for resistance- and virulence factor accumulation in pathogenic bacteria such as Staphylococcus aureus. Methods: Here, we have investigated the ...
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2013-07-16ZeitschriftenartikelA Mouse Model for Human Norovirus Human noroviruses (HuNoVs) cause significant morbidity and mortality worldwide. However, despite substantial efforts, a small-animal model for HuNoV has not been described to date. Since "humanized" mice have been successfully ...
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2014-08-07ZeitschriftenartikelA multi-country outbreak of Salmonella Newport gastroenteritis in Europe associated with watermelon from Brazil, confirmed by whole genome sequencing: October 2011 to January 2012 In November 2011, the presence of Salmonella Newport in a ready-to-eat watermelon slice was confirmed as part of a local food survey in England. In late December 2011, cases of S. Newport were reported in England, Wales, ...
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2020-11-28ZeitschriftenartikelA Multi-Omics Protocol for Swine Feces to Elucidate Longitudinal Dynamics in Microbiome Structure and Function Swine are regarded as promising biomedical models, but the dynamics of their gastrointestinal microbiome have been much less investigated than that of humans or mice. The aim of this study was to establish an integrated ...
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2023-05-11ZeitschriftenartikelA multicentre external quality assessment: A first step to standardise PCR protocols for the diagnosis of histoplasmosis and coccidioidomycosis Background In-house real-time PCR (qPCR) is increasingly used to diagnose the so-called endemic mycoses as commercial assays are not widely available. Objectives To compare the performance of different molecular ...
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2014-08-14ZeitschriftenartikelA multicentre sero-behavioural survey for hepatitis B and C, HIV and HTLV among people who inject drugs in Germany using respondent driven sampling Background: People who inject drugs are at high risk for hepatitis B, hepatitis C and HIV. HTLV was reported by neighboring countries to be prevalent in this population, but the situation for Germany is unclear. To ...
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2006-01-27ZeitschriftenartikelA New Bacillus anthracis Found in Wild Chimpanzees and a Gorilla from West and Central Africa