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Auflistung Artikel in Fachzeitschriften nach Autor "Mellmann, Alexander"
Anzeige der Publikationen 1-19 von 19
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2023-04-13ZeitschriftenartikelAktuelle molekulare Epidemiologie und Antibiotikaresistenzen von Clostridioides difficile in Deutschland im Jahr 2022 Berger, Fabian K.; Mellmann, Alexander; von Müller, Lutz; Gärtner, BarbaraClostridioides (C.) difficile ist der bedeutendste bakte¬rielle Erreger infektiöser nosokomialer Diarrhöen. Wichtigster Risikofaktor für eine Erkrankung ist die Gabe von Antibiotika, die die Darmflora schädigen – insbesondere ...
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2008-08-01ZeitschriftenartikelAnalysis of collection of hemolytic uremic syndrome-associated enterohemorrhagic Escherichia coli. Mellmann, Alexander; Bielaszewska, Martina; Köck, Robin; Friedrich, Alexander W.; Fruth, Angelika; Middendorf, Barbara; Harmsen, Dag; Schmidt, M. Alexander; Karch, HelgeMultilocus sequence typing of 169 non-O157 enterohemorrhagic Escherichia coli (EHEC) isolated from patients with hemolytic uremic syndrome (HUS) demonstrated 29 different sequence types (STs); 78.1% of these strains clustered ...
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2018-08-31ZeitschriftenartikelAttack of the clones: whole genome-based characterization of two closely related enterohemorrhagic Escherichia coli O26 epidemic lineages Karnisova, Lucia; Marejkova, Monika; Hrbackova, Hana; Mellmann, Alexander; Karch, Helge; Fruth, Angelika; Drevinek, Pavel; Blahova, Kveta; Bielaszewska, Martina; Nunvar, JaroslavBackground: Enterohemorrhagic Escherichia coli (EHEC) O26:H11/H−, the most common non-O157 serotype causing hemolytic uremic syndrome worldwide, are evolutionarily highly dynamic with new pathogenic clones emerging ...
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2018-04-05ZeitschriftenartikelAusbruchsuntersuchungen bei Clostridium (Clostridioides) difficile Berger, Fabian; Mellmann, Alexander; Müller, Lutz von; Gärtner, BarbaraClostridium difficile (neue Taxonomie Clostridioides difficile) kann neben leichten klinischen Verläufen auch schwerwiegende Infektionen verursachen. Im Krankenhausumfeld und anderen Einrichtungen des Gesundheitswesens, ...
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2011-06-22ZeitschriftenartikelCharacterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study Bielaszewska, Martina; Mellmann, Alexander; Zhang, Wenlan; Köck, Robin; Fruth, Angelika; Bauwens, Andreas; Peters, Georg; Karch, HelgeBackground: In an ongoing outbreak of haemolytic uraemic syndrome and bloody diarrhoea caused by a virulent Escherichia coli strain O104:H4 in Germany (with some cases elsewhere in Europe and North America), 810 cases ...
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2011-01-04ZeitschriftenartikelChromosomal instability in enterohaemorrhagic Escherichia coli O157:H7: impact on adherence, tellurite resistance and colony phenotype. Bielaszewska, Martina; Middendorf, Barbara; Tarr, Phillip I.; Zhang, Wenlan; Prager, Rita; Aldick, Thomas; Dobrindt, Ulrich; Karch, Helge; Mellmann, AlexanderTellurite (Tel) resistant enterohaemorrhagic Escherichia coli (EHEC) O157:H7 is a global pathogen. In strain EDL933 Tel resistance (Tel(R) ) is encoded by duplicate ter cluster in O islands (OI) 43 and 48, which also harbour ...
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2018-09-10ZeitschriftenartikelComparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398 Busche, Tobias; Hillion, Mélanie; Van Loi, Vu; Berg, David; Walther, Birgit; Semmler, Torsten; Strommenger, Birgit; Witte, Wolfgang; Cuny, Christiane; Mellmann, Alexander; Holmes, Mark A.; Kalinowski, Jörn; Adrian, Lorenz; Bernhardt, Jörg; Antelmann, HaikeThe spread of methicillin-resistant Staphylococcus aureus (MRSA) in the community, hospitals and in livestock is mediated by highly diverse virulence factors that include secreted toxins, superantigens, enzymes and ...
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2014-01-10ZeitschriftenartikelHeteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6 Bielaszewska, Martina; Schiller, Roswitha; Lammers, Lydia; Bauwens, Andreas; Fruth, Angelika; Middendorf, Barbara; Schmidt, Alexander; Tarr, Phillip I.; Dobrindt, Ulrich; Karch, Helge; Mellmann, AlexanderExtraintestinal pathogenic and intestinal pathogenic (diarrheagenic) Escherichia coli differ phylogenetically and by virulence profiles. Classic theory teaches simple linear descent in this species, where non-pathogens ...
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2015-07-31ZeitschriftenartikelHighly Virulent Non-O157 Enterohemorrhagic Escherichia coli (EHEC) Serotypes Reflect Similar Phylogenetic Lineages, Providing New Insights into the Evolution of EHEC Eichhorn, Inga; Heidemanns, Katrin; Semmler, Torsten; Kinnemann, Bianca; Mellmann, Alexander; Harmsen, Dag; Anjum, Muna F.; Schmidt, Herbert; Fruth, Angelika; Valentin-Weigand, Peter; Heesemann, Jürgen; Suerbaum, Sebastian; Karch, Helge; Wieler, Lothar H.Enterohemorrhagic Escherichia coli (EHEC) is the causative agent of bloody diarrhea and extraintestinal sequelae in humans, most importantly hemolytic-uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). ...
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2017-02-03ZeitschriftenartikelHost cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury Bielaszewska, Martina; Rüter, Christian; Bauwens, Andreas; Greune, Lilo; Jarosch, Kevin-André; Steil, Daniel; Zhang, Wenlan; He, Xiaohua; Lloubes, Roland; Fruth, Angelika; Kim, Kwang Sik; Schmidt, M. Alexander; Dobrindt, Ulrich; Mellmann, Alexander; Karch, HelgeOuter membrane vesicles (OMVs) are important tools in bacterial virulence but their role in the pathogenesis of infections caused by enterohemorrhagic Escherichia coli (EHEC) O157, the leading cause of life-threatening ...
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2017-05-25ZeitschriftenartikelOngoing haemolytic uraemic syndrome (HUS) outbreak caused by sorbitol-fermenting (SF) Shiga toxinproducing Escherichia coli (STEC) O157, Germany, December 2016 to May 2017 Vygen-Bonnet, Sabine; Rosner, Bettina; Wilking, Hendrik; Fruth, Angelika; Prager, Rita; Kossow, A.; Lang, Christina; Simon, Sandra; Seidel, Juliane; Faber, Mirko; Schielke, Anika; Michaelis, Kai; Holzer, Alexandra; Kamphausen, R.; Kalhöfer, D.; Thole, S.; Mellmann, Alexander; Flieger, Antje; Stark, KlausWe report an ongoing, protracted and geographically dispersed outbreak of haemolytic uraemic syndrome (HUS) and gastroenteritis in Germany, involving 30 cases since December 2016. The outbreak was caused by the sorbitol-fermenting ...
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2017-11-20ZeitschriftenartikelOrigin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8 Strauß, Lena; Stegger, Marc; Akpaka, Patrick Eberechi; Alabi, Abraham; Breurec, Sebastien; Coombs, Geoffrey; Egyir, Beverly; Larsen, Anders Rhod; Laurent, Frederic; Monecke, Stefan; Peters, Georg; Skov, Robert; Strommenger, Birgit; Vandenesch, François; Schaumburg, Frieder; Mellmann, AlexanderUSA300 is a pandemic clonal lineage of hypervirulent, community-acquired, methicillin-resistant Staphylococcus aureus (CA-MRSA) with specific molecular characteristics. Despite its high clinical relevance, the evolutionary ...
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2009-09-01ZeitschriftenartikelPhylogeny and Disease Association of Shiga toxin-Producing Escherichia coli O91 Mellmann, Alexander; Fruth, Angelika; Friedrich, Alexander W.; Wieler, Lothar H.; Harmsen, Dag; Werber, Dirk; Middendorf, Barbara; Bielaszewska, Martina; Karch, HelgeThe diversity and relatedness of 100 Shiga toxin–producing Escherichia coli O91 isolates from different patients were examined by multilocus sequence typing. We identified 10 specific sequence types (ST) and 4 distinct ...
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2023-05-11ZeitschriftenartikelPlasmid-vermittelte Colistinresistenz bei Mitarbeitenden in putenhaltenden Betrieben Scharlach, Martina; Rocker, Dagmar; Claußen, Katja; Effelsberg, Natalie; Müller, Ilona; Egelkamp, Richard; Roth, Sara; Mellmann, Alexander; Köck, RobinDas Polymyxin-Antibiotikum Colistin ist in Deutschland seit 2012 als (Last-Line-)Antibiotikum für die systemische Therapie schwerer Infektionen mit multiresistenten Erregern zugelassen. 2016 wurde erstmals das Plasmid-vermittelte ...
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2021-11-27ZeitschriftenartikelPrevalence and zoonotic transmission of colistin-resistant and carbapenemase-producing Enterobacterales on German pig farms Effelsberg, Natalie; Kobusch, Iris; Linnemann, Sabrina; Hofmann, Franka; Schollenbruch, Hannah; Mellmann, Alexander; Boelhauve, Marc; Köck, Robin; Cuny, ChristianeThe treatment of infections due to colistin-resistant (Col-E) and carbapenemase-producing (CPE) Enterobacterales challenges clinicians both in human and veterinary medicine. Preventing zoonotic transmission of these ...
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2011-07-20ZeitschriftenartikelProspective genomic characterization of the German enterohemorrhagic escherichia coli O104:H4 outbreak by rapid next generation sequencing technology. Mellmann, Alexander; Harmsen, Dag; Cummings, Craig A.; Zentz, Emily B.; Leopold, Shana R.; Rico, Alain; Prior, Karola; Szczepanowski, Rafael; Ji, Yongmei; Zhang, Wenlan; McLaughlin, Stephen F.; Henkhaus, John K.; Leopold, Benjamin; Bielaszewska, Martina; Prager, Rita; Brzoska, Pius M.; Moore, Richard L.; Guenther, Simone; Rothberg, Jonathan M.; Karch, HelgeAn ongoing outbreak of exceptionally virulent Shiga toxin (Stx)-producing Escherichia coli O104:H4 centered in Germany, has caused over 830 cases of hemolytic uremic syndrome (HUS) and 46 deaths since May 2011. Serotype ...
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2011-11-18ZeitschriftenartikelSynergistic Adaptive Mutations in the Hemagglutinin and Polymerase Acidic Protein Lead to Increased Virulence of Pandemic 2009 H1N1 Influenza A Virus in Mice Seyer, Roman; Hrincius, Eike R.; Ritzel, Dorothea; Abt, Marion; Mellmann, Alexander; Marjuki, Henju; Kühn, Joachim; Wolff, Thorsten; Ludwig, Stephan; Ehrhardt, ChristinaInfluenza impressively reflects the paradigm of a viral disease in which continued evolution of the virus is of paramount importance for annual epidemics and occasional pandemics in humans. Because of the continuous threat ...
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2019-11-21ZeitschriftenartikelÜberarbeitung der RKI Empfehlungen für die Wiederzulassung zu Gemeinschaftseinrichtungen gemäß § 34 IfSG nach EHEC-Infektion Pörtner, Kirsten; Fruth, Angelika; Flieger, Antje; Middendorf-Bauchart, Barbara; Mellmann, Alexander; Falkenhorst, GerhardInfektionen mit Enterohämorrhagischen E. coli (EHEC) verlaufen meist ohne schwere Komplikationen, können aber zu blutigen Durchfällen und in seltenen Fällen zum lebensbedrohlichen hämolytisch-urämischen Syndrom (HUS) führen. ...
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2015-08-18ZeitschriftenartikelVirulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain Kunsmann, Lisa; Rüter, Christian; Bauwens, Andreas; Greune, Lilo; Glüder, Malte; Kemper, Björn; Fruth, Angelika; Wai, Sun Nyunt; He, Xiaohua; Lloubes, Roland; Schmidt, M. Alexander; Dobrindt, Ulrich; Mellmann, Alexander; Karch, Helge; Bielaszewska, MartinaThe highly virulent Escherichia coli O104:H4 that caused the large 2011 outbreak of diarrhoea and haemolytic uraemic syndrome secretes blended virulence factors of enterohaemorrhagic and enteroaggregative E. coli, but their ...