2017-11-14Zeitschriftenartikel
Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors
Meixenberger, Karolin; Yousef, Kaveh Pouran; Smith, Maureen Rebecca; Somogyi, Sybille; Fiedler, Stefan; Bartmeyer, Barbara; Hamouda, Osamah; Bannert, Norbert; Kleist, Max von; Kücherer, Claudia
Background: Detailed knowledge of the evolutionary potential of polymorphic sites in a viral protein is important for understanding the development of drug resistance in the presence of an inhibitor. We therefore set ...