2020-09-12Zeitschriftenartikel
Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir
Patasic, Lea; Seifried, Janna; Bezler, Valerie; Kaljanac, Marcell; Schneider, Irene C.; Schmitz, Heike; Tondera, Christiane; Hartmann, Jessica; Hombach, Andreas; Buchholz, Christian J.; Abken, Hinrich; König, Renate; Cichutek, Klaus
Chimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and ...
