2024-05-31Zeitschriftenartikel
Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models
Hynds, Robert E.; Huebner, Ariana; Pearce, David R.; Hill, Mark S.; Akarca, Ayse U.; Moore, David A.; Ward, Sophia; Gowers, Kate H. C.; Karasaki, Takahiro; Al Bakir, Maise; Wilson, Gareth A.; Pich, Oriol; Martínez-Ruiz, Carlos; Md Mukarram Hossain, A. S.; Pearce, Simon P.; Sivakumar, Monica; Ben Aissa, Assma; Grönroos, Eva; Chandrasekharan, Deepak; Kolluri, Krishna K.; Towns, Rebecca; Wang, Kaiwen; Cook, Daniel E.; Bosshard-Carter, Leticia; Naceur-Lombardelli, Cristina; Rowan, Andrew J.; Verriah, Selvaraju; Litchfield, Kevin; Crosbie, Philip A. J.; Dive, Caroline; Quezada, Sergio A.; Janes, Sam M.; Jamal-Hanjani, Mariam; Marafioti, Teresa; TRACERx consortium; McGranahan, Nicholas
Patient-derived xenograft (PDX) models are widely used in cancer research. To investigate the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX models from 22 patients enrolled in the TRACERx ...
