Artikel in Fachzeitschriften: Neuzugänge
Anzeige der Publikationen 241-260 von 4620
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2023-02-16ZeitschriftenartikelComparative effectiveness of contact tracing interventions in the context of the COVID-19 pandemic: a systematic review Contact tracing is a non-pharmaceutical intervention (NPI) widely used in the control of the COVID-19 pandemic. Its effectiveness may depend on a number of factors including the proportion of contacts traced, delays in ...
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2022-12-21ZeitschriftenartikelGenetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia The effectiveness of metronidazole against the tetraploid intestinal parasite Giardia lamblia is dependent on its activation/inactivation within the cytoplasm. There are several activating enzymes, including pyruvate ...
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2023-02-10ZeitschriftenartikelDisease severity in hospitalized COVID-19 patients: comparing routine surveillance with cohort data from the LEOSS study in 2020 in Germany Introduction Studies investigating risk factors for severe COVID-19 often lack information on the representativeness of the study population. Here, we investigate factors associated with severe COVID-19 and compare the ...
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2023-04-02ZeitschriftenartikelMonitoring the SARS-CoV-2 Pandemic: Prevalence of Antibodies in a Large, Repetitive Cross-Sectional Study of Blood Donors in Germany—Results from the SeBluCo Study 2020–2022 SARS-CoV-2 serosurveillance is important to adapt infection control measures and estimate the degree of underreporting. Blood donor samples can be used as a proxy for the healthy adult population. In a repeated cross-sectional ...
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2023-09-28ZeitschriftenartikelAktualisierung der Empfehlungen der STIKO zur Standardimpfung von Personen ≥ 60 Jahre sowie zur Indikationsimpfung von Risikogruppen gegen Pneumokokken und die dazugehörige wissenschaftliche Begründung Erkrankungen durch S. pneumoniae gehören zu den häufigsten bakteriellen Atemwegsinfektionen weltweit. Auch in Deutschland sind Hospitalisierungen und Todesfälle aufgrund von Pneumokokken-Infektionen häufig. Personen ≥ 60 ...
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2023-11-23ZeitschriftenartikelAuf dem Weg zum Ende von AIDS? Die HIV-Epidemie in Deutschland Vor 40 Jahren wurde das Humane Immundefizienz-Virus (HIV) erstmals als das Virus identifiziert und beschrieben, welches das erworbene Immunschwächesyndrom AIDS (Acquired Immunodeficiency Syndrome) verursacht. Vor diesem ...
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2023-11-23ZeitschriftenartikelEinfluss des Kriegs in der Ukraine auf gemeldete HIV-Neudiagnosen in Deutschland Die HIV-Prävalenz in der Ukraine wurde im Jahr 2019 bezogen auf die Gesamtbevölkerung auf 0,9 – 1,0 % geschätzt, wobei die Prävalenz in bestimmten vulnerablen Gruppen deutlich höher liegen dürfte. Durch den Angriffskrieg ...
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2023-02-11ZeitschriftenartikelDistinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19 Prolonged lung pathology has been associated with COVID-19, yet the cellular and molecular mechanisms behind this chronic inflammatory disease are poorly understood. In this study, we combine advanced imaging and spatial ...
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2023-02-06ZeitschriftenartikelVisualization of SARS-CoV-2 particles in naso/oropharyngeal swabs by thin section electron microscopy Background SARS-CoV-2 replicates efficiently in the upper airways of humans and produces high loads of virus RNA and, at least in the initial phase after infection, many infectious virus particles. Studying virus ...
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2023-01-18ZeitschriftenartikelCrystal structures of OrfX1, OrfX2 and the OrfX1–OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1 Botulinum neurotoxins (BoNTs) are among the most lethal toxins known to humans, comprising seven established serotypes termed BoNT/A–G encoded in two types of gene clusters (ha and orfX) in BoNT-producing clostridia. The ...
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2023-02-10ZeitschriftenartikelSituational pathogen avoidance mediates the impact of social connectedness on preventive measures during the COVID-19 pandemic During the COVID-19 pandemic, physical distancing was one of the more important behaviours for reducing the spread of the virus. The present study investigated the influence on pathogen avoidance of familiarity with other ...
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2022-01-11ZeitschriftenartikelPrioritizing health information for national health reporting - a Delphi study of the Joint Action on Health Information (InfAct) Background Health information (HI) strategies exist in several EU Member States, however, they mainly focus on technical issues and improving governance rather than on content-related priority setting. There is also ...
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2022-01-14ZeitschriftenartikelEpidemiologie der Virushepatitiden A bis E in Deutschland Mit Virushepatitis A bis E werden verschiedene infektiöse Entzündungen des Leberparenchyms bezeichnet, die durch die Hepatitisviren A bis E (HAV, HBV, HCV, HDV und HEV) ausgelöst werden. Zwar ähneln sich die Krankheitsbilder, ...
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2022-01-14ZeitschriftenartikelSARS-CoV-2 outbreaks in hospitals and long-term care facilities in Germany: a national observational study Background Outbreaks of coronavirus disease (COVID-19) in hospitals and long-term care facilities (LTCFs) pose serious public health threats. We analysed how frequency and size of SARS-CoV-2 outbreaks in hospitals and ...
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2022-01-13ZeitschriftenartikelCost-savings and potential cost-savings through the distribution of generic antiretroviral drugs within the statutory health insurance market of Germany between January 2017 and June 2019 Background: Recent patent losses for antiretroviral drugs (ARV) have led to the debate of cost-saving through the replacement of patented drugs with generic drugs. The split of recommended single-tablet regimens (STR) ...
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2021-12-23ZeitschriftenartikelNumerical approaches for the rapid analysis of prophylactic efficacy against HIV with arbitrary drug-dosing schemes Pre-exposure prophylaxis (PrEP) is an important pillar to prevent HIV transmission. Because of experimental and clinical shortcomings, mathematical models that integrate pharmacological, viral- and host factors are ...
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2022-01-08ZeitschriftenartikelChanges in healthcare seeking and lifestyle in old aged individuals during COVID-19 lockdown in Germany: the population-based AugUR study Background: Containment measures in the COVID-19 pandemic protected individuals at high risk, particularly individuals at old age, but little is known about how these measures affected health-related behavior of old ...
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2023-11-16ZeitschriftenartikelZur Situation bei wichtigen Infektionskrankheiten – Importierte Infektionskrankheiten 2022 Der im Epidemiologischen Bulletin 46/2023 veröffentlichte Bericht zu reiseassoziierten Erkrankungen 2022 basiert auf den Meldedaten gemäß Infektionsschutzgesetz, die dem RKI mit Datenstand 1. März 2023 übermittelt wurden. ...
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2023-05-18ZeitschriftenartikelStrengthening national public health institutes: a systematic review on institution building in the public sector Introduction: Strong and efficient institutions are vital to the development of well-functioning governments and strong societies. The term “institution building” encompasses the creation, support, development, and ...
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2023-05-12ZeitschriftenartikelCombination of whole genome sequencing and supervised machine learning provides unambiguous identification of eae-positive Shiga toxin-producing Escherichia coli Introduction: The objective of this study was to develop, using a genome wide machine learning approach, an unambiguous model to predict the presence of highly pathogenic STEC in E. coli reads assemblies derived from ...