Browsing Artikel in Fachzeitschriften by Author "Nübel, Ulrich"
Now showing items 1-20 of 22
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2007-11-15ZeitschriftenartikelA case of Clostridium difficile-associated disease due to the highly virulent clone of Clostridium difficile PCR ribotype 027, March 2007 in Germany Zaiß, Henning; Weile, J.; Ackermann, G.; Kuijper, Ed J.; Witte, Wolfgang; Nübel, Ulrich
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2013-01-08ZeitschriftenartikelA genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic Holden, Matthew T.G.; Hsu, Li-Yang; Kurt, Kevin; Weinert, Lucy A.; Mather, Alison E.; Harris, Simon R.; Strommenger, Birgit; Layer, Franziska; Witte, Wolfgang; Lencastre, Herminia de; Skov, Robert; Westh, Henrik; Zemličková, Helena; Coombs, Geoffrey; Kearns, Angela M.; Hill, Robert L.R.; Edgeworth, Jonathan; Gould, Ian; Gant, Vanya; Cooke, Jonathan; Edwards, Giles F.; McAdam, Paul R.; Templeton, Kate E.; McCann, Angela; Nübel, UlrichThe widespread use of antibiotics in association with high-density clinical care has driven the emergence of drug-resistant bacteria that are adapted to thrive in hospitalized patients. Of particular concern are globally ...
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2010-04-08ZeitschriftenartikelA Timescale for Evolution, Population Expansion, and Spatial Spread of an Emerging Clone of Methicillin-Resistant Staphylococcus aureus Nübel, Ulrich; Dordel, Janina; Kurt, Kevin; Strommenger, Birgit; Westh, Henrik; Shukla, Sanjay K.; Zemličková, Helena; Leblois, Raphaël; Wirth, Thierry; Jombart, Thibaut; Balloux, François; Witte, WolfgangDue to the lack of fossil evidence, the timescales of bacterial evolution are largely unknown. The speed with which genetic change accumulates in populations of pathogenic bacteria, however, is a key parameter that is ...
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2011-05-05ZeitschriftenartikelAntibiotic resistance and molecular epidemiology of Staphylococcus aureus in Nigeria Shittu, Adebayo; Okon, Kenneth; Adesida, Solayide; Oyedara, Omotayo; Witte, Wolfgang; Strommenger, Birgit; Layer, Franziska; Nübel, UlrichBackground: Staphylococcus aureus is an important pathogen causing a wide range of infections in the hospital and community setting. In order to have adequate information for treatment of S. aureus infections, it is crucial ...
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2009-06-15ZeitschriftenartikelCharacterization of methicillin-resistant Staphylococcus aureus (MRSA) isolates from hospitals in KwaZulu-Natal (KZN) province, Republic of South Africa Shittu, Adebayo; Nübel, Ulrich; Udo, Edet; Lin, Johnson; Steven, Sedio GaogakweEpidemiological data based on phenotypic and molecular characterization of methicillin-resistant Staphylococcus aureus (MRSA) in sub-Saharan Africa are limited. This investigation studied 61 MRSA isolates obtained from 13 ...
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2016-06-17ZeitschriftenartikelComparison of six commercial kits to extract bacterial chromosome and plasmid DNA for MiSeq sequencing Becker, Laura; Steglich, Matthias; Fuchs, Stephan; Werner, Guido; Nübel, UlrichWe compared commercial kits for extraction of genomic DNA from the Gram-negative bacterium Klebsiella pneumoniae for subsequent Miseq sequencing. Purification of DNA was based on matrix binding (silica or anion exchange ...
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2015-07-09ZeitschriftenartikelComplete Genome Sequence of a CTX-M-15-Producing Klebsiella pneumoniae Outbreak Strain from Multilocus Sequence Type 514 Becker, Laura; Bunk, Boyke; Eller, Christoph; Steglich, Matthias; Pfeifer, Yvonne; Werner, Guido; Nübel, UlrichWe report here the genome sequence of a multidrug-resistant Klebsiella pneumoniae strain, which caused an outbreak in a neonatal ward in 2011. The genome consists of a single chromosome (5,278 kb) and three plasmids (362 ...
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2015-03-12ZeitschriftenartikelComprehensive molecular, genomic and phenotypic analysis of a major clone of Enterococcus faecalis MLST ST40 Zischka, Melanie; Künne, Carsten T.; Blom, Jochen; Wobser, Dominique; Sakιnç, Türkân; Schmidt-Hohagen, Kerstin; Dabrowski, Piotr Wojtek; Nitsche, Andreas; Hübner, Johannes; Hain, Torsten; Chakraborty, Trinad; Linke, Burkhard; Goesmann, Alexander; Voget, Sonja; Daniel, Rolf; Schomburg, Dietmar; Hauck, Rüdiger; Hafez, Hafez M.; Tielen, Petra; Bender, Jennifer K.; Steglich, Matthias; Nübel, Ulrich; Witte, Wolfgang; Werner, GuidoBackground: Enterococcus faecalis is a multifaceted microorganism known to act as a beneficial intestinal commensal bacterium. It is also a dreaded nosocomial pathogen causing life-threatening infections in hospitalised ...
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2012-01-18ZeitschriftenartikelEvaluation of adding a second marker to overcome Staphylococcus aureus spa-typing homoplasies Basset, P.; Nübel, Ulrich; Witte, Wolfgang; Blanc, D. S.The utility of sequencing a second highly variable locus in addition to the spa gene (e.g., double-locus sequence typing [DLST]) was investigated to overcome limitations of a Staphylococcus aureus single-locus typing method. ...
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2010-04-01ZeitschriftenartikelFluoroquinolone Resistance and Clostridium difficile, Germany Zaiß, Henning; Witte, Wolfgang; Nübel, UlrichWe characterized 670 Clostridium diffi cile isolates collected from patients in 84 hospitals in Germany in 2008. PCR ribotyping showed high prevalence of ribotype 001 and restricted dissemination of ribotype 027 strains. ...
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2011-10-07ZeitschriftenartikelFrom types to trees: Reconstructing the spatial spread of Staphylococcus aureus based on DNA variation Nübel, Ulrich; Strommenger, Birgit; Layer, Franziska; Witte, WolfgangTracing the spatial spread of pathogens is a key objective of molecular infectious disease epidemiology. Accordingly, a wide range of genotyping approaches have been used to monitor the dissemination of Staphylococcus ...
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2012-07-02ZeitschriftenartikelHigh Resolution Discrimination of Clinical Mycobacterium tuberculosis Complex Strains Based on Single Nucleotide Polymorphisms Homolka, Susanne; Projahn, Michaela; Feuerriegel, Silke; Ubben, Tanja; Diel, Roland; Nübel, Ulrich; Niemann, StefanRecently, the diversity of the Mycobacterium tuberculosis complex (MTBC) population structure has been described in detail. Based on geographical separation and specific host pathogen co-evolution shaping MTBC virulence ...
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2013-01-31ZeitschriftenartikelMRSA Transmission on a Neonatal Intensive Care Unit: Epidemiological and Genome-Based Phylogenetic Analyses Nübel, Ulrich; Nachtnebel, Matthias; Falkenhorst, Gerhard; Benzler, Justus; Hecht, Jochen; Kube, Michael; Bröcker, Felix; Moelling, Karin; Bührer, Christoph; Gastmeier, Petra; Piening, Brar; Behnke, Michael; Dehnert, Manuel; Layer, Franziska; Witte, Wolfgang; Eckmanns, TimBackground: Methicillin-resistant Staphylococcus aureus (MRSA) may cause prolonged outbreaks of infections in neonatal intensive care units (NICUs). While the specific factors favouring MRSA spread on neonatal wards are ...
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2021KonferenzveröffentlichungNeeds for an Integration of Specific Data Sources and Items – First Insights of a National Survey Within the German Center for Infection Research Jakob, Carolin E.M.; Stecher, Melanie; Fuhrmann, Sandra; Wingen-Heimann, Sebastian; Heinen, Stephanie; Anton, Gabriele; Behnke, Michael; Behrends, Uta; Boeker, Martin; Castell, Stefanie; Demski, Hans; Diefenbach, Maximilian; Falgenhauer, Jane C.; Fritzenwanker, Moritz; Gastmeier, Petra; Gerhard, Markus; Glöckner, Stephan; Golubovic, Mira; Gunsenheimer-Bartmeyer, Barbara; Ingenerf, Josef; Kaiser, Rolf; Körner, Marie-Luise; Loag, Wibke; McHardy, Alice; Molitor, Ernst; Nübel, Ulrich; Pritsch, Michael; Ramharter, Michael; Rieg, Sigbert R.; Rupp, Jan; Schindler, Daniela; Schwudke, Dominik; Spinner, Christoph; Stottmeier, Benjamin; Vehreschild, Maria; Willmann, Matthias; Vehreschild, Jörg J.State-subsidized programs develop medical data integration centers in Germany. To get infection disease (ID) researchers involved in the process of data sharing, common interests and minimum data requirements were prioritized. ...
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2014-02-04ZeitschriftenartikelPhylogenetic Analysis of Staphylococcus aureus CC398 Reveals a Sub-Lineage Epidemiologically Associated with Infections in Horses Abdelbary, Mohamed M. H.; Wittenberg, Anne; Cuny, Christiane; Layer, Franziska; Kurt, Kevin; Wieler, Lothar H.; Walther, Birgit; Skov, Robert; Larsen, Jesper; Hasman, Henrik; Fitzgerald, J. Ross; Smith, Tara C.; Wagenaar, J. A.; Pantosti, Annalisa; Hallin, Marie; Struelens, Marc J.; Edwards, Giles; Böse, R.; Nübel, Ulrich; Witte, WolfgangIn the early 2000s, a particular MRSA clonal complex (CC398) was found mainly in pigs and pig farmers in Europe. Since then, CC398 has been detected among a wide variety of animal species worldwide. We investigated the ...
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2012-03-09ZeitschriftenartikelSingle-Nucleotide Polymorphism Genotyping Identifies a Locally Endemic Clone of Methicillin-Resistant Staphylococcus aureus Nübel, Ulrich; Nitsche, Andreas; Layer, Franziska; Strommenger, Birgit; Witte, WolfgangWe developed, tested, and applied a TaqMan real-time PCR assay for interrogation of three single-nucleotide polymorphisms that differentiate a clade (termed ‘t003-X’) within the radiation of methicillin-resistant Staphylococcus ...
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2013-03-26ZeitschriftenartikelStaphylococcus aureus toxins – Their functions and genetics Grumann, Dorothee; Nübel, Ulrich; Bröker, Barbara M.The outcome of encounters between Staphylococcus (S.) aureus and its human host ranges from life-threatening infection through allergic reactions to symptom-free colonization. The pan-genome of this bacterial species encodes ...
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2013-03-07ZeitschriftenartikelSubpopulations of Staphylococcus aureus Clonal Complex 121 Are Associated with Distinct Clinical Entities Kurt, Kevin; Rasigade, Jean-Philippe; Laurent, Frederic; Goering, Richard V.; Zemličková, Helena; Machova, Ivana; Struelens, Marc J.; Zautner, Andreas E.; Holtfreter, Silva; Bröker, Barbara; Ritchie, Stephen; Reaksmey, Sin; Limmathurotsakul, Direk; Peacock, Sharon J.; Cuny, Christiane; Layer, Franziska; Witte, Wolfgang; Nübel, UlrichWe investigated the population structure of Staphylococcus aureus clonal complex CC121 by mutation discovery at 115 genetic housekeeping loci from each of 154 isolates, sampled on five continents between 1953 and 2009. In ...
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2015-10-07ZeitschriftenartikelTracing the Spread of Clostridium difficile Ribotype 027 in Germany Based on Bacterial Genome Sequences Steglich, Matthias; Nitsche, Andreas; Müller, Lutz von; Herrmann, Mathias; Kohl, Thomas A.; Niemann, Stefan; Nübel, UlrichWe applied whole-genome sequencing to reconstruct the spatial and temporal dynamics underpinning the expansion of Clostridium difficile ribotype 027 in Germany. Based on re-sequencing of genomes from 57 clinical C. difficile ...
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2009-01-08ZeitschriftenartikelTyping Clostridium difficile strains based on tandem repeat sequences Zaiß, Henning; Rupnik, Maja; Kuijper, Ed J.; Harmanus, Celine; Michielsen, Dolf; Janssens, Koen; Nübel, UlrichBackground: Genotyping of epidemic Clostridium difficile strains is necessary to track their emergence and spread. Portability of genotyping data is desirable to facilitate inter-laboratory comparisons and epidemiological ...