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Auflistung Artikel in Fachzeitschriften nach Autor "von Kleist, Max"
Anzeige der Publikationen 1-20 von 22
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2022-08-15ZeitschriftenartikelAdvancing Precision Vaccinology by Molecular and Genomic Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 in Germany, 2021 Oh, Djin-Ye; Hölzer, Martin; Paraskevopolou, Sofia; Tofimova, Maria; Hartkopf, Felix; Budt, Matthias; Wedde, Marianne; Richard, Hugues; Haldemann, Berit; Domaszewska, Teresa; Reiche, Janine; Keeren, Kathrin; Radonić, Aleksander; Ramos Calderón, Julia Patricia; Smith, Maureen Rebecca; Brinkmann, Annika; Trappe, Kathrin; Drechsel, Oliver; Klaper, Kathleen; Hein, Sascha; Hildt, Eberhardt; Haas, Walter; Calvignac-Spencer, Sébastien; Semmler, Torsten; Dürrwald, Ralf; Thürmer, Andrea; Drosten, Christian; Fuchs, Stephan; Kröger, Stefan; von Kleist, Max; Wolff, Thorsten; Integrated Molecular Surveillance for SARS-CoV-2 (IMS-SC2) Laboratory NetworkBackground Comprehensive pathogen genomic surveillance represents a powerful tool to complement and advance precision vaccinology. The emergence of the Alpha variant in December 2020 and the resulting efforts to track ...
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2021-04-20ZeitschriftenartikelAn intra-host SARS-CoV-2 dynamics model to assess testing and quarantine strategies for incoming travelers, contact management, and de-isolation van der Toorn, Wiep; Oh, Djin-Ye; Bourquain, Daniel; Michel, Janine; Krause, Eva; Nitsche, Andreas; von Kleist, MaxNon-pharmaceutical interventions (NPIs) remain decisive tools to contain SARS-CoV-2. Strategies that combine NPIs with testing may improve efficacy and shorten quarantine durations. We developed a stochastic within-host ...
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2019-02-07ZeitschriftenartikelAnalysis of long non-coding RNA and mRNA expression in bovine macrophages brings up novel aspects of Mycobacterium avium subspecies paratuberculosis infections Gupta, Pooja; Peter, Sarah; Jung, Markus; Lewin, Astrid; Hemmrich-Stanisak, Georg; Franke, Andre; von Kleist, Max; Schütte, Christof; Einspanier, Ralf; Sharbati, Soroush; zur Bruegge, JenniferParatuberculosis is a major disease in cattle that severely affects animal welfare and causes huge economic losses worldwide. Development of alternative diagnostic methods is of urgent need to control the disease. Recent ...
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2023-05-04ZeitschriftenartikelAnwendungsbereiche von künstlicher Intelligenz im Kontext von One Health mit Fokus auf antimikrobielle Resistenzen Irrgang, Christopher; Eckmanns, Tim; von Kleist, Max; Antão, Esther-Maria; Ladewig, Katharina; Wieler, Lothar H.Die Gesundheit der Menschen steht vor einer Reihe neuer Herausforderungen, die maßgeblich durch den fortschreitenden Klimawandel, den demografischen Wandel und die Globalisierung angetrieben werden. Der One-Health-Ansatz ...
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2020-03-12ZeitschriftenartikelAutophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring Kiral, Ferdi Ridvan; Linneweber, Gerit Arne; Mathejczyk, Thomas; Georgiev, Svilen Veselinov; Wernet, Mathias F.; Hassan, Bassem A.; von Kleist, Max; Hiesinger, Peter RobinBrain wiring is remarkably precise, yet most neurons readily form synapses with incorrect partners when given the opportunity. Dynamic axon-dendritic positioning can restrict synaptogenic encounters, but the spatiotemporal ...
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2021-12-21ZeitschriftenartikelBrain connectivity inversely scales with developmental temperature in Drosophila Kiral, Ferdi Ridvan; Dutta, Suchetana B.; Linneweber, Gerit Arne; Hilgert, Selina; Poppa, Caroline; Duch, Carsten; von Kleist, Max; Hassan, Bassem A.; Hiesinger, P. RobinVariability of synapse numbers and partners despite identical genes reveals the limits of genetic determinism. Here, we use developmental temperature as a non-genetic perturbation to study variability of brain wiring and ...
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2020-11-04ZeitschriftenartikelComputational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research Hufsky, Franziska; Lamkiewicz, Kevin; Almeida, Alexandre; Aouacheria, Abdel; Arighi, Cecilia; Bateman, Alex; Baumbach, Jan; Beerenwinkel, Niko; Brandt, Christian; Cacciabue, Marco; Chuguransky, Sara; Drechsel, Oliver; Finn, Robert D; Fritz, Adrian; Fuchs, Stephan; Hattab, Georges; Hauschild, Anne-Christin; Heider, Dominik; Hoffmann, Marie; Hölzer, Martin; Hoops, Stefan; Kaderali, Lars; Kalvari, Ioanna; von Kleist, Max; Kmiecinski, Renó; Kühnert, Denise; Lasso, Gorka; Libin, Pieter; List, Markus; Löchel, Hannah F.; Martin, Maria J.; Martin, Roman; Matschinske, Julian; McHardy, Alice C.; Mendes, Pedro; Mistry, Jaina; Navratil, Vincent; Nawrocki, Eric P.; O'Toole, Áine Niamh; Ontiveros-Palacios, Nancy; Petrov, Anton I; Rangel-Pineros, Guillermo; Redaschi, Nicole; Reimering, Susanne; Reinert, Knut; Reyes, Alejandro; RIchardson, Lorna; Robertson, David L.; Sadegh, Sepideh; Singer, Joshua B.; Theys, Kristof; Upton, Chris; Welzel, Marius; Williams, Lowri; Marz, ManjaSARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of coronaviruses has been studied for many years. ...
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2021-04-20ZeitschriftenartikelCOVIDStrategyCalculator: A software to assesstesting and quarantine strategies for incomingtravelers, contact management, and de-isolation van der Toorn, Wiep; Oh, Djin-Ye; von Kleist, MaxWhile large-scale vaccination campaigns against SARS-CoV-2 are rolled out at the time of writing, non-pharmaceutical interventions (NPIs), including the isolation of infected individuals and quarantine of exposed individuals, ...
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2021-09-10ZeitschriftenartikelInferring gene regulatory networks from single-cell RNA-seq temporal snapshot data requires higher-order moments Raharinirina, Nomenjanahary Alexia; Peppert, Felix; von Kleist, Max; Schütte, Christof; Sunkara, VikramSingle-cell RNA sequencing (scRNA-seq) has become ubiquitous in biology. Recently, there has been a push for using scRNA-seq snapshot data to infer the underlying gene regulatory networks (GRNs) steering cellular function. ...
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2022-01-04ZeitschriftenartikelInvestigation of a Limited but Explosive COVID-19 Outbreak in a German Secondary School Baumgarte, Sigrid; Hartkopf, Felix; Hölzer, Martin; von Kleist, Max; Neitz, Sabine; Kriegel, Martin; Bollongino, KirstenThe role of schools as a source of infection and driver in the coronavirus-pandemic has been controversial and is still not completely clarified. To prevent harm and disadvantages for children and adolescents, but also ...
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2021-04-27ZeitschriftenartikelITN—VIROINF: Understanding (Harmful) Virus-Host Interactions by Linking Virology and Bioinformatics Goettsch, Winfried; Beerenwinkel, Niko; Deng, Li; Dölken, Lars; Dutilh, Bas E.; Erhard, Florian; Kaderali, Lars; von Kleist, Max; Marquet, Roland; Matthijnssens, Jelle; McCallin, Shawna; McMahon, Dino; Rattei, Thomas; Van Rij, Ronald P.; Robertson, David L.; Schwemmle, Martin; Stern-Ginossar, Noam; Marz, ManjaMany recent studies highlight the fundamental importance of viruses. Besides their important role as human and animal pathogens, their beneficial, commensal or harmful functions are poorly understood. By developing and ...
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2021-07-13ZeitschriftenartikelMathematical Modelling of the Molecular Mechanisms of Interaction of Tenofovir with Emtricitabine against HIV Iannuzzi, Sara; von Kleist, MaxThe combination of the two nucleoside reverse transcriptase inhibitors (NRTI) tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) is used in most highly active antiretroviral therapies for treatment of HIV-1 ...
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2021-03-31ZeitschriftenartikelMaßnahmen zur Bewältigung der COVID-19-Pandemie in Deutschland: nichtpharmakologische und pharmakologische Ansätze Grote, Ulrike; Arvand, Mardjan; Brinkwirth, Simon; Brunke, Melanie; Buchholz, Udo; Eckmanns, Tim; von Kleist, Max; Niebank, Michaela; Ruehe, Bettina; Schulze, Kai; Stoliaroff-Pépin, Anna; Thanheiser, Marc; Schaade, Lars; Said, Dunja; Haas, WalterBeim ersten Auftreten des Erregers SARS-CoV‑2 im Dezember 2019 standen weder spezifische therapeutische Möglichkeiten noch ein Impfstoff zur Verfügung. Auch in Deutschland rückten deshalb nichtpharmakologische Maßnahmen ...
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2021-12-23ZeitschriftenartikelNumerical approaches for the rapid analysis of prophylactic efficacy against HIV with arbitrary drug-dosing schemes Zhang, Lanxin; Wang, Junyu; von Kleist, MaxPre-exposure prophylaxis (PrEP) is an important pillar to prevent HIV transmission. Because of experimental and clinical shortcomings, mathematical models that integrate pharmacological, viral- and host factors are ...
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2021-10-14ZeitschriftenartikelRapid incidence estimation from SARS-CoV-2 genomes reveals decreased case detection in Europe during summer 2020 Smith, Maureen Rebecca; Trofimova, Maria; Weber, Ariane; Duport, Yannick; Kühnert, Denise; von Kleist, MaxBy October 2021, 230 million SARS-CoV-2 diagnoses have been reported. Yet, a considerable proportion of cases remains undetected. Here, we propose GInPipe, a method that rapidly reconstructs SARS-CoV-2 incidence profiles ...
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2021-07-21ZeitschriftenartikelRise and Fall of SARS-CoV-2 Lineage A.27 in Germany Calvignac-Spencer, Sébastien; Budt, Matthias; Huska, Matthew; Richard, Hugues; Leipold, Luca; Grabenhenrich, Linus; Semmler, Torsten; von Kleist, Max; Kröger, Stefan; Wolff, Thorsten; Hölzer, MartinHere, we report on the increasing frequency of the SARS-CoV-2 lineage A.27 in Germany during the first months of 2021. Genomic surveillance identified 710 A.27 genomes in Germany as of 2 May 2021, with a vast majority ...
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2021-07-29ZeitschriftenartikelSARS-CoV-2-Übertragungswege und Implikationen für den Selbst- und Fremdschutz Oh, Djin-Ye; Böttcher, Sindy; Kröger, Stefan; von Kleist, MaxDie weltweite Ausbreitung des Coronavirus SARS-CoV‑2 hat Gesundheits‑, Wirtschafts- und Gesellschaftssysteme massiv in Mitleidenschaft gezogen. Obwohl mittlerweile effektive Impfstoffe zur Verfügung stehen, ist es ...
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2021-03-05ZeitschriftenartikelSARS-CoV-2-Varianten: Evolution im Zeitraffer Oh, Djin-Ye; Kröger, Stefan; Wedde, Marianne; Hartkopf, Felix; Budt, Matthias; Seifried, Janna; Radonic, Aleksandar; Belarbi, Essia; Hölzer, Martin; Böttcher, Sindy; Schubert, Grit; Kaiser, Sandra; Sachse, Andreas; Drechsel, Oliver; Grajcar, Romina; Huska, Matthew; Lanxin, Zhan; Domaszewska, Teresa; Zhang, Lanxin; Brinkmann, Annika; Yahosseini, Kyanoush; Grabenhenrich, Linus; Hamouda, Osamah; Dürrwald, Ralf; Haas, Walter; Calvignac-Spencer, Sébastien; Semmler, Torsten; Schaade, Lars; Mielke, Martin; von Kleist, Max; Fuchs, Stephan; Wieler, Lothar H.; Wolff, ThorstenDas Betacoronavirus SARS-CoV-2 gelangte höchstwahrscheinlich als zoonotischer Erreger gegen Ende 2019 in die menschliche Bevölkerung, vermutlich in Form einer einzelnen Transmission (monophyletischer Ursprung) aus einem ...
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2020-11-20ZeitschriftenartikelSARS-CoV-2: Testergebnisse richtig einordnen Lein, Ines; Leuker, Christina; Antão, Esther-Maria; von Kleist, Max; Jenny, Mirjam A.Diagnostische Antigen-Tests („Schnelltests“) können dabei helfen, akut mit SARS-CoV-2 infizierte Personen zu identifizieren. Sie weisen SARS-CoV-2-Proteine nach und sind schneller und preiswerter als PCR-Tests. Gegenwärtig ...
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2022-03-28ZeitschriftenartikelShort- and long-range interactions in the HIV-1 5′ UTR regulate genome dimerization and packaging Ye, Liqing; Gribling-Burrer, Anne-Sophie; Bohn, Patrick; Kibe, Anuja; Börtlein, Charlene; Ambi, Uddhav B.; Ahmad, Shazeb; Olguin-Nava, Marco; Smith, Maureen; Caliskan, Neva; von Kleist, Max; Smyth, Redmond P.RNA dimerization is the noncovalent association of two human immunodeficiency virus-1 (HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a prerequisite for binding to the viral structural ...