Browsing Artikel in Fachzeitschriften by Author "Bock, C.-Thomas"
Now showing items 1-14 of 14
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2022-02-02ZeitschriftenartikelAdvanced sequencing approaches detected insertions of viral and human origin in the viral genome of chronic hepatitis E virus patients Papp, C.‑Patrick; Biedermann, Paula; Harms, Dominik; Wang, Bo; Kebelmann, Marianne; Choi, Mira; Helmuth, Johannes; Corman, Victor M.; Thürmer, Andrea; Altmann, Britta; Klink, Patrycja; Hofmann, Jörg; Bock, C.‑ThomasThe awareness of hepatitis E virus (HEV) increased significantly in the last decade due to its unexpectedly high prevalence in high-income countries. There, infections with HEV-genotype 3 (HEV-3) are predominant which can ...
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2019-03-04ZeitschriftenartikelCharacterization of a hepatitis C virus genotype 1 divergent isolate from an HIV-1 coinfected individual in Germany assigned to a new subtype 1o Wang, Bo; Krüger, Luise; Machnowska, Patrycja; Eshetu, Amare; Gunsenheimer-Bartmeyer, Barbara; Bremer, Viviane; Hauser, Andrea; Bannert, Norbert; Bock, C. ThomasBackground HCV exhibits a high genetic diversity and is classified into 7 genotypes which are further divided into 86 confirmed subtypes. However, there are multiple isolates with unassigned subtypes. We aimed to amplify ...
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2019-01-03ZeitschriftenartikelComplete Genome Sequence of a Hepatitis E Virus Genotype 1e Strain from an Outbreak in Nigeria, 2017 Akanbi, Olusola Anuoluwapo; Harms, Dominik; Wang, Bo; Opaleye, Oluyinka Oladele; Adesina, Olufisayo; Osundare, Folakemi Abiodun; Ogunniyi, Abiodun; Naidoo, Dhamari; Devaux, Isabelle; Wondimagegnehu, Alemu; Peter, Clement; Ifeanyi, Okudo; Ogundiran, Opeayo; Ugochukwu, Uzoma; Mba, Nwando; Omilabu, Sunday A.; Ihekweazu, Chikwe; Bock, C. ThomasHepatitis E virus genotype 1 (HEV-1) is associated with large epidemics. Notably, HEV subtype 1e (HEV-1e) has caused HEV outbreaks in sub-Saharan Africa. We report here the second full-length genome sequence of an HEV-1e ...
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2021-06-29ZeitschriftenartikelDetection of Q129H Immune Escape Mutation in Apparently Healthy Hepatitis B Virus Carriers in Southwestern Nigeria Adesina, Olufisayo Adeyemi; Akanbi, Olusola Anuoluwapo; Opaleye, Oluyinka Oladele; Japhet, Margaret Oluwatoyin; Wang, Bo; Oluyege, Adekemi Olubukunola; Klink, Patrycja; Bock, C.-ThomasAs the global effort to eradicate hepatitis B continues, immune escape mutations (IEMs) and drug resistance mutations (DRMs) affecting its diagnosis, treatment, and prevention are compromising this goal. However, knowledge ...
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2022-01-14ZeitschriftenartikelEpidemiologie der Virushepatitiden A bis E in Deutschland Dudareva, Sandra; Faber, Mirko; Zimmermann, Ruth; Bock, C.-Thomas; Offergeld, Ruth; Steffen, Gyde; Enkelmann, JuliaMit Virushepatitis A bis E werden verschiedene infektiöse Entzündungen des Leberparenchyms bezeichnet, die durch die Hepatitisviren A bis E (HAV, HBV, HCV, HDV und HEV) ausgelöst werden. Zwar ähneln sich die Krankheitsbilder, ...
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2021-03-24ZeitschriftenartikelGenetic Diversity of Enteric Viruses in Children under Five Years Old in Gabon Manouana, Gédéon Prince; Nguema-Moure, Paul Alvyn; Ngwese, Mirabeau Mbong; Bock, C.-Thomas; Kremsner, Peter G.; Borrmann, Steffen; Eibach, Daniel; Mordmüller, Benjamin; Velavan, Thirumalaisamy P.; Niendorf, Sandra; Adegnika, Ayola AkimEnteric viruses are the leading cause of diarrhea in children globally. Identifying viral agents and understanding their genetic diversity could help to develop effective preventive measures. This study aimed to determine ...
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2021-04-29ZeitschriftenartikelHepatitis E virus infection in high-risk populations in Osun State, Nigeria Osundare, Folakemi Abiodun; Klink, Patrycja; Akanbi, Olusola Aanuoluwapo; Wang, Bo; Harms, Dominik; Ojurongbe, Olusola; Ajayi, Moses Adedapo; Babaranti, Emmanuel Oluwagbenga; Bock, C.-Thomas; Opaleye, Oladele OluyinkaHepatitis E virus (HEV) infection is an emerging infection that is of major public health concern, especially in some vulnerable groups like immunosuppressed individuals, pregnant women and HBV-coinfected individuals. HEV ...
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2022-02-02ZeitschriftenartikelIntra-host analysis of hepaciviral glycoprotein evolution reveals signatures associated with viral persistence and clearance Gömer, André; Brown, Richard J. P.; Pfaender, Stephanie; Deterding, Katja; Reuter, Gábor; Orton, Richard; Seitz, Stefan; Bock, C.- Thomas; Cavalleri, Jessika M. V.; Pietschmann, Thomas; Wedemeyer, Heiner; Steinmann, Eike; Todt, DanielEven 30 years after the discovery of the hepatitis C virus (HCV) in humans there is still no vaccine available. Reasons for this include the high mutation rate of HCV, which allows the virus to escape immune recognition ...
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2019-01-24ZeitschriftenartikelNTCP S267F variant associates with decreased susceptibility to HBV and HDV infection and decelerated progression of related liver diseases Binh, Mai Thanh; Xuan Hoan, Nghiem; Van Tong, Hoang; Sy, Bui Tien; Trung, Ngo Tat; Bock, C. Thomas; Toan, Nguyen Linh; Song, Le Huu; Bang, Mai Hong; Meyer, Christian G.; Kremsner, Peter G.; Velavan, Thirumalaisamy P.Objectives To determine potential associations of the rs2296651 variant (c.800C > T, S267F) of NTCP with HBV and HBV plus concomitant HDV infection as well as with the progression of related liver diseases. Methods The ...
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2021-01-15ZeitschriftenartikelPrevalence and characteristics of hepatitis B and D virus infections among HIV-positive individuals in Southwestern Nigeria Opaleye, Oluyinka Oladele; Akanbi, Olusola Anuoluwapo; Osundare, Folakemi Abiodun; Wang, Bo; Adesina, Olufisayo; Sunday, Sola Thomas; Akindele, Abiodun Akeem; Klink, Patrycja; Bock, C. ThomasBackground Coinfections of HIV-positive individuals with Hepatitis B and D virus (HBV and HDV) are common and can be associated with rapid liver damage. Several antiretroviral drugs for HIV exhibit anti-HBV effect; ...
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2021-02-26ZeitschriftenartikelSerological evidence of avian HEV antibodies in apparently healthy chickens in southwest Nigeria Osamudiamen, Fisayo Temilade; Akanbi, Olusola Aanuoluwapo; Oluwayelu, Daniel Oladimeji; Bock, C. -Thomas; Klink, PatrycjaAvian hepatitis E virus (aHEV) is associated with hepatitis-splenomegaly syndrome, big liver and spleen disease and hepatic rupture haemorrhage syndrome. However, the knowledge about aHEV in commercial layer chickens in ...
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2017-02-04ZeitschriftenartikelSOCS3 genetic variants and promoter hypermethylation in patients with chronic hepatitis B Hoan, Nghiem Xuan; Tong, Hoang Van; Giang, Dao Phuong; Cuong, Bui Khac; Toan, Nguyen Linh; Wedemeyer, Heiner; Bock, C. Thomas; Kremsner, Peter G.; Song, Le Huu; Velavan, Thirumalaisamy P.The clinical manifestations of hepatitis B viral infection (HBV) include chronic hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC). The contribution of negative regulator suppressor of cytokine ...
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2020-03-24ZeitschriftenartikelSpecific circulating microRNAs during hepatitis E infection can serve as indicator for chronic hepatitis E Harms, Dominik; Choi, Mira; Allers, Kristina; Wang, Bo; Pietsch, Heiko; Papp, C.-Patrick; Hanisch, Lina; Kurreck, Jens; Hofmann, Jörg; Bock, C.-ThomasHepatitis E virus (HEV) genotypes 3 and 4 (HEV-3, HEV-4) infections are an emerging public health issue in industrialized countries. HEV-3 and −4 are usually self-limiting but can progress to chronic hepatitis E in ...
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2019-03-06ZeitschriftenartikelTelbivudine Reduces Parvovirus B19-Induced Apoptosis in Circulating Angiogenic Cells Zobel, Thomas; Bock, C. Thomas; Kühl, Uwe; Rohde, Maria; Lassner, Dirk; Schultheiss, Heinz-Peter; Schmidt-Lucke, CarolineAims: Human parvovirus B19 (B19V) infection directly induces apoptosis and modulates CXCR4 expression of infected marrow-derived circulating angiogenic cells (CACs). This leads to dysfunctional endogenous vascular repair. ...