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2021-07-22ZeitschriftenartikelSports activity patterns and cardio-metabolic health over time among adults in Germany: Results of a nationwide 12-year follow-up study Background Physical activity is favorable for health, and vigorous sports activity is particularly beneficial. This study investigates the association between changes in sports participation patterns over time and ...
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2021-08-25ZeitschriftenartikelCoordinated action of multiple transporters in the acquisition of essential cationic amino acids by the intracellular parasite Toxoplasma gondii Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino acids from their hosts. We previously identified a large family of apicomplexan-specific plasma membrane-localized amino ...
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2021-04-01ZeitschriftenartikelGenomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-Producing Escherichia coli Strains From Healthy Food Animals Across Europe The role of livestock animals as a putative source of ESBL/pAmpC E. coli for humans is a central issue of research. In a large-scale pan-European surveillance, 2,993 commensal Escherichia spp. isolates were recovered from ...
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2021-12-14ZeitschriftenartikelTranscriptional Active Parvovirus B19 Infection Predicts Adverse Long-Term Outcome in Patients with Non-Ischemic Cardiomyopathy Parvovirus B19 (B19V) is the predominant cardiotropic virus currently found in endomyocardial biopsies (EMBs). However, direct evidence showing a causal relationship between B19V and progression of inflammatory cardiomyopathy ...
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2021-05ZeitschriftenartikelActive Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018–2020 Human bornavirus encephalitis is a severe and often fatal infection caused by variegated squirrel bornavirus 1 (VSBV-1) and Borna disease virus 1 (BoDV-1). We conducted a prospective study of bornavirus etiology of ...
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2021-04-30ZeitschriftenartikelProphylaxis and treatment of influenza: options, antiviral susceptibility, and existing recommendations Influenza viruses of types A and B attack 5–10% of adults and 20–30% of children, thereby causing millions of acute respiratory infections in Germany annually. A significant number of these infections are associated with ...
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2021-12-14ZeitschriftenartikelInsights into the direct anti-influenza virus mode of action of Rhodiola rosea Background: The anti-influenza A virus activities and contents of previously isolated most active flavonoids (rhodiosin and tricin) from a standardized hydro-ethanolic R. rosea root and rhizome extract (SHR-5®), did not ...
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2021-08-04ZeitschriftenartikelGene Set Enrichment Analysis Reveals Individual Variability in Host Responses in Tuberculosis Patients Group-aggregated responses to tuberculosis (TB) have been well characterized on a molecular level. However, human beings differ and individual responses to infection vary. We have combined a novel approach to individual ...
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2020-11-19ZeitschriftenartikelEndogenous retroviruses expressed in human tumours cannot be used as targets for anti-tumour vaccines Many tumour cells express on their surface proteins of endogenous retroviruses (ERVs) and there are suggestions to use these retroviral antigens as target for anti-tumour vaccines. However, until now there is no convincing ...
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2021-06-22ZeitschriftenartikelStructure of Chimpanzee Gut Microbiomes across Tropical Africa Understanding variation in host-associated microbial communities is important given the relevance of microbiomes to host physiology and health. Using 560 fecal samples collected from wild chimpanzees (Pan troglodytes) ...
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2024-06-07Berichte und sonstige TexteGrippeWeb-Wochenbericht KW 22 Kalenderwoche 22 (27.5. – 2.6.2024), Datenstand: 4.6.2024Die Aktivität akuter Atemwegserkrankungen (ARE-Inzidenz) in der Bevölkerung ist in der 22. KW 2024 im Vergleich zur Vorwoche insgesamt leicht gestiegen und lag bei rund 4.900 ARE pro 100.000 Einw. (Vorwoche: 4.500). Die ...
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2024-06-06ZeitschriftenartikelAnalyse der Datenqualität nach Einführung der elektronischen Labormeldung über DEMIS Die Einführung automatisierter, elektronischer Meldungen von Infektionskrankheiten ist insbesondere in großen Ländern und bei dezentraler Organisation des Gesundheitssystems herausfordernd. In Deutschland wurde dafür das ...
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2024-06-06Berichte und sonstige TexteWastewater-based Surveillance on SARS-CoV-2 AMELAG - Weekly report 05.06.2024The SARS-CoV-2 viral load in wastewater is being monitored as part of AMELAG (“Abwassermonitoring für die epidemiologische Lagebewertung”, German for wastewater monitoring for epidemiological situation assessment). Data ...
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2024-06-06Berichte und sonstige TexteAbwassersurveillance zu SARS-CoV-2 AMELAG-Wochenbericht vom 05.06.2024Im Rahmen von AMELAG (Abwassermonitoring für die epidemiologische Lagebewertung) wird unter anderem die Last von SARS-CoV-2 im Abwasser überwacht. Aktuell fließen Daten aus 164 Standorten, d.h. Kläranlagen, in die Analysen ...
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2021-06-24ZeitschriftenartikelA global metagenomic map of urban microbiomes and antimicrobial resistance We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an ...
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2024-06Heft oder Ausgabe einer ZeitschriftARE-Wochenbericht KW 22 22. Kalenderwoche (27.5. bis 2.6.2024)Das ARE-Geschehen wird durch Erkältungsviren wie Rhinoviren bestimmt. Die Zahl schwer verlaufender Atemwegsinfektionen bleibt weiterhin auf einem niedrigen Niveau. Die Aktivität akuter respiratorischer Erkrankungen (ARE) ...
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2021-11-13ZeitschriftenartikelEvaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohort Background Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) seem to be highly transmissible, often infect otherwise healthy humans and frequently occur in hospital outbreaks. Methods Refugees, ...
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2021-07-08ZeitschriftenartikelEditorial: Pathogenomics of the Genus Brucella and Beyond
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2021-03-21ZeitschriftenartikelThe Spatiotemporal Dynamics and Microevolution Events That Favored the Success of the Highly Clonal Multidrug-Resistant Monophasic Salmonella Typhimurium Circulating in Europe The European epidemic monophasic variant of Salmonella enterica serovar Typhimurium (S. 1,4,[5],12:i:-) characterized by the multi locus sequence type ST34 and the antimicrobial resistance ASSuT profile has become one of ...
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2021-11-11ZeitschriftenartikelHospital-acquired infections caused by enterococci: a systematic review and meta-analysis, WHO European Region, 1 January 2010 to 4 February 2020 Background Hospital-acquired infections (HAI) caused by Enterococcus spp., especially vancomycin-resistant Enterococcusspp. (VRE), are of rising concern. Aim We summarised data on incidence, mortality and proportion ...