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2021-11-05ZeitschriftenartikelNeue Therapiealgorithmen: COVID-19 von leicht bis schwer richtig behandeln Diese COVRIIN-Handlungs- empfehlungen sollen behan- delnden Ärzten eine prakti- sche Hilfestellung für alltägliche Entscheidungen in der Klinik sein. Sie sind als lebendes Dokument zu verstehen und unter www.rki.de ...
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2021-03-15ZeitschriftenartikelChanges in the prevalence of self-reported sexually transmitted bacterial infections from 2010 and 2017 in two large European samples of men having sex with men–is it time to re-evaluate STI-screening as a control strategy? Background/Objectives Many European countries reported increased numbers of syphilis, gonorrhoea and chlamydia diagnoses among men who have sex with men (MSM) in recent years. Behaviour changes and increased testing are ...
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2021-10-12ZeitschriftenartikelKnock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5−/− Mice Arachidonic acid 5-lipoxygenase (ALOX5) is the key enzyme in the biosynthesis of pro- inflammatory leukotrienes. We recently created knock-in mice (Alox5-KI) which express an arachi- donic acid 15-lipoxygenating Alox5 ...
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2021-10-24ZeitschriftenartikelMolecular surveillance and genetic divergence of rotavirus A antigenic epitopes in Gabonese children with acute gastroenteritis Background Rotavirus A (RVA) causes acute gastroenteritis in children <5 years of age in sub-Saharan Africa. In this study, we described the epidemiology and genetic diversity of RVA infecting Gabonese children and ...
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2021-08-05ZeitschriftenartikelToward a Common Performance and Effectiveness Terminology for Digital Proximity Tracing Applications Digital proximity tracing (DPT) for Sars-CoV-2 pandemic mitigation is a complex intervention with the primary goal to notify app users about possible risk exposures to infected persons. DPT not only relies on the technical ...
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2021-10-08ZeitschriftenartikelCross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination INTRODUCTION The clinical manifestations of COVID-19 vary from asymptomatic infection to respiratory failure. Severe disease courses are primarily associated with advanced age, immune dysfunctions, and comorbidities. ...
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2021-01-13ZeitschriftenartikelDevelopment and Evaluation of an Immuno-MALDI-TOF Mass Spectrometry Approach for Quantification of the Abrin Toxin in Complex Food Matrices The toxin abrin found in the seeds of Abrus precatorius has attracted much attention regarding criminal and terroristic misuse over the past decade. Progress in analytical methods for a rapid and unambiguous identification ...
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2021-07-17ZeitschriftenartikelStaphylococcus aureus nasal colonization among dental health care workers in Northern Germany (StaphDent study) Methicillin-resistant Staphylococcus aureus (MRSA) can colonize dental patients and students, however, studies on the prevalence of MRSA and methicillin-susceptible S. aureus (MSSA) among dental health care workers ...
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2021-12-14ZeitschriftenartikelErfahrungsbericht: Auf dem Weg zum ganzheitlichen Forschungsdatenmanagement Forschungsdatenmanagement im institutionellen Kontext spielt eine immer größere Rolle. Allerdings existieren bisher nur wenige technische Plattformen, die eine Ver- waltung der Forschungsdaten gemäß den FAIR-Prinzipien ...
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2021-09-21ZeitschriftenartikelRe-Emergence and Spread of Haemorrhagic Septicaemia in Germany: The Wolf as a Vector? Since 2010, outbreaks of haemorrhagic septicaemia (HS) caused by Pasteurella (P.) multocida capsular type B (PmB) emerged in Germany. In 2017, we noticed a close spatiotemporal relationship between HS outbreak sites and ...
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2021-08-18ZeitschriftenartikelCharacterization of Campylobacter spp. Strains Isolated From Wild Birds in Turkey Turkey is an important stopover site for many migrating birds between Europe, Asia and Africa. Campylobacter spp. are frequently found in wildlife, in particular waterfowl, and distinct strains are disseminated within ...
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2021-04-24ZeitschriftenartikelMetabolic adaption of Legionella pneumophila during intracellular growth in Acanthamoeba castellanii The metabolism of Legionella pneumophila strain Paris was elucidated during different time intervals of growth within its natural host Acanthamoeba castellanii. For this purpose, the amoebae were supplied after ...
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2021-12-01ZeitschriftenartikelA Genetic Variation of Lipopolysaccharide Binding Protein Affects the Inflammatory Response and Is Associated with Improved Outcome during Sepsis LPS binding protein (LBP) is an important innate sensor of microbial cell wall structures. Frequent functionally relevant mutations exist and have been linked to influence susceptibility to and course of bacterial infections. ...
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2021-05-21ZeitschriftenartikelPhylogenetic Tracking of LA-MRSA ST398 Intra-Farm Transmission among Animals, Humans and the Environment on German Dairy Farms Methicillin-resistant Staphylococcus aureus (MRSA) are a major threat to human and animal health, causing difficult-to-treat infections. The aim of our study was to evaluate the intra-farm transmission of livestock-associated ...
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2021-04-23ZeitschriftenartikelWhat makes a market transaction morally repugnant? Many people find it morally impermissible to put kidneys, jury duty exemptions, or permits for having children on the free market. All of these are examples of repugnant transactions—market transactions that third ...
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2021-12-15ZeitschriftenartikelPharmacologically induced endolysosomal cholesterol imbalance through clinically licensed drugs itraconazole and fluoxetine impairs Ebola virus infection in vitro Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus (EBOV). The latest occasional EVD outbreak (2013–2016) in Western African, which was accompanied by a high fatality rate, showed the ...
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2021-12-25ZeitschriftenartikelSARS-CoV-2 Aerosol Transmission Indoors: A Closer Look at Viral Load, Infectivity, the Effectiveness of Preventive Measures and a Simple Approach for Practical Recommendations There is uncertainty about the viral loads of infectious individuals required to transmit COVID-19 via aerosol. In addition, there is a lack of both quantification of the influencing parameters on airborne transmission ...
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2021-04-21ZeitschriftenartikelExcess costs of type 2 diabetes and their sociodemographic and clinical determinants: a cross-sectional study using data from the German Health Interview and Examination Survey for Adults (DEGS1) Objectives The objectives of this study were to estimate the direct and indirect excess costs of type 2 diabetes mellitus (T2D) using data representative for the German adult population and to investigate the association ...
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2021-05-04ZeitschriftenartikelThe case for developing a cohesive systems approach to research across unhealthy commodity industries Objectives Most non-communicable diseases are preventable and largely driven by the consumption of harmful products, such as tobacco, alcohol, gambling and ultra-processed food and drink products, collectively termed ...
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2021-07-18ZeitschriftenartikelReal-Time PCR for Molecular Detection of Zoonotic and Non-Zoonotic Giardia spp. in Wild Rodents Giardiasis in humans is a gastrointestinal disease transmitted by the potentially zoonotic Giardia duodenalis genotypes (assemblages) A and B. Small wild rodents such as mice and voles are discussed as potential reservoirs ...