edoc.rki.de - Open Access Publikationsserver: Neuzugänge
Anzeige der Publikationen 9901-9920 von 12525
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2017-03-19ZeitschriftenartikelMutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration Tenofovir disoproxil fumarate (TDF) genotypic resistance defined by K65R/N and/or K70E/Q/G occurs in 20% to 60% of individuals with virological failure (VF) on a WHO-recommended TDF-containing first-line regimen. However, ...
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2017-05-12ZeitschriftenartikelA third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH Background: Visceral leishmaniasis (VL or kala azar) is the most serious form of human leishmaniasis, responsible for over 20,000 deaths annually, and post kala azar dermal leishmaniasis (PKDL) is a stigmatizing skin ...
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2017-05-30ZeitschriftenartikelDifferent features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections Background: Human Ebola infection is characterized by a paralysis of the immune system. A signature of αβ T cells in fatal Ebola infection has been recently proposed, while the involvement of innate immune cells in the ...
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2017-05-04ZeitschriftenartikelOne-Health-Konzept: Eine Antwort auf resistente Bakterien? One-Health-Konzept: Die bessere Vernetzung zwischen Tier- und Humanmedizin soll abgestimmte Interventionen gewährleisten und evidenzbasierte Maßnahmen ermöglichen.
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2017-06-30ZeitschriftenartikelEstablishing an ICD-10 code based SARI-surveillance in Germany – description of the system and first results from five recent influenza seasons Background: Syndromic surveillance of severe acute respiratory infections (SARI) is important to assess seriousness of disease as recommended by WHO for influenza. In 2015 the Robert Koch Institute (RKI) started to ...
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2017-06-21ZeitschriftenartikelDifferential Substrate Usage and Metabolic Fluxes in Francisella tularensis Subspecies holarctica and Francisella novicida Francisella tularensis is an intracellular pathogen for many animals causing the infectious disease, tularemia. Whereas F. tularensis subsp. holarctica is highly pathogenic for humans, F. novicida is almost avirulent for ...
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2017-07-06ZeitschriftenartikelDecreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control Background: Herpes simplex infections (HSV1/2) are characterized by recurrent symptoms, a risk of neonatal herpes, and the facilitation of HIV transmission. In Germany, HSV1/2 infections are not notifiable and data are ...
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2017-07-03ZeitschriftenartikelParents with mental health problems and their children in a German population based sample: Results of the BELLA study Background: Mental health problems (MHP) of parents are associated with an increased risk of psychological and developmental difficulties in their children. This study aims at analyzing population-based data of parents ...
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2017-07-06ZeitschriftenartikelLegionnaires’ disease in Europe, 2011 to 2015 Under the coordination of the European Centre for Disease Prevention and Control (ECDC), the European Legionnaires’ disease Surveillance Network (ELDSNet) conducts surveillance of Legionnaires’ disease (LD) in Europe. ...
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2017-07-11ZeitschriftenartikelSurveillance of recent HIV infections among newly diagnosed HIV cases in Germany between 2008 and 2014 Background: The HIV surveillance system in Germany is based on mandatory, anonymous notification of newly diagnosed HIV cases by laboratories. Because the time between HIV infection and the diagnosis of HIV varies widely ...
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2015-06-24ZeitschriftenartikelEbola Virus Disease Outbreak in Isiro, Democratic Republic of the Congo, 2012: Signs and Symptoms, Management and Outcomes Data collected during the 2012 Ebola virus disease (EVD) epidemic in the Democratic Republic of the Congo were analysed for clinical signs, symptoms and case fatality of EVD caused by Bundibugyo virus (BDBV), establishment ...
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2016-06-16ZeitschriftenartikelOnly the complex N559-glycan in SV2C mediates high affinity binding to botulinum neurotoxin serotype A1 The extraordinary potency of botulinum neurotoxins (BoNTs) is mediated by their high neurospecificity, targeting peripheral cholinergic motoneurons leading to flaccid paralysis and successive respiratory failure. Complex ...
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2016-02-01ZeitschriftenartikelPrionen III - 4
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2017-05-01ZeitschriftenartikelExternal quality assessment study for ebolavirus PCR-diagnostic promotes international preparedness during the 2014 – 2016 Ebola outbreak in West Africa During the recent Ebola outbreak in West Africa several international mobile laboratories were deployed to the mainly affected countries Guinea, Sierra Leone and Liberia to provide ebolavirus diagnostic capacity. Additionally, ...
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2017-07-01ZeitschriftenartikelLive Cell Therapy as Potential Risk Factor for Q Fever During an outbreak of Q fever in Germany, we identified an infected sheep flock from which animals were routinely used as a source for life cell therapy (LCT), the injection of fetal cells or cell extracts from sheep into ...
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2017-07-06ZeitschriftenartikelGrippeWeb als wichtiges Instrument in der Vorbereitung und Bewältigung einer zukünftigen Pandemie GrippeWeb ist ein vom RKI entwickeltes, bevölkerungsbasiertes Überwachungsinstrument für akute Atemwegserkrankungen. Es ging 2011 online und die Teilnehmerzahl wuchs seitdem kontinuierlich. Es ist ein robustes System, ...
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2017-06-29ZeitschriftenartikelHepatitis E virus infection in Europe: surveillance and descriptive epidemiology of confirmed cases, 2005 to 2015 Hepatitis E virus (HEV) is an under-recognised cause of acute hepatitis in high-income countries. The purpose of this study was to provide an overview of testing, diagnosis, surveillance activities, and data on confirmed ...
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2017-06-15ZeitschriftenartikelThe Human Immunodeficiency Virus Continuum of Care in European Union Countries in 2013: Data and Challenges Background: The Joint United Nations Programme on HIV/AIDS (UNAIDS) has set a "90-90-90" target to curb the human immunodeficiency virus (HIV) epidemic by 2020, but methods used to assess whether countries have reached ...
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2017-06-29ZeitschriftenartikelBericht des Nationalen Referenzzentrums (NRZ) für gramnegative Krankenhauserreger Zeitraum 1. Januar 2016 – 31. Dezember 2016Die Resistenzen bei gramnegativen Bakterien haben in den vergangenen Jahren zugenommen, beispielsweise die Resistenz von Escherichia coli und Klebsiella pneumoniae gegenüber bestimmten Klassen von Antibiotika, z.B. ...
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2017-06-07ZeitschriftenartikelTranslational Rodent Models for Research on Parasitic Protozoa—A Review of Confounders and Possibilities Rodents, in particular Mus musculus, have a long and invaluable history as models for human diseases in biomedical research, although their translational value has been challenged in a number of cases. We provide some ...