edoc.rki.de - Open Access Publikationsserver: Recent submissions
Now showing items 321-340 of 13284
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2024-05-02ZeitschriftenartikelHuman macrophages infected with Egyptian Rousette bat-isolated Marburg virus display inter-individual susceptibility and antiviral responsiveness Marburg virus (MARV) is a highly pathogenic filovirus and a causative agent of sporadic zoonotic viral hemorrhagic fever outbreaks with high case fatality rates. In humans, filoviruses like MARV and Zaire Ebola virus (EBOV) ...
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2024-12-21ZeitschriftenartikelThe impact of information and communication technology on immunisation and immunisation programmes in low-income and middle-income countries: a systematic review and meta-analysis Background: Low-income and Middle-income Countries (LMIC) are continually working to ensure everyone can access life-saving vaccines. Recognising the considerable impact of Information and Communication Technology (ICT) ...
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2024-01-20ZeitschriftenartikelVaccine-induced neutralizing antibodies bind to the H protein of a historical measles virus Measles is a highly contagious airborne viral disease. It can lead to serious complications and death and is preventable by vaccination. The live-attenuated measles vaccine (LAMV) derived from a measles virus (MV) isolated ...
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2024-03-27ZeitschriftenartikelGene knock-out in Mycobacterium abscessus using Streptococcus thermophilus CRISPR/Cas The CRISPRi system using dCas9Sth1 from Streptococcus thermophilus developed for Mycobacterium tuberculosis and M. smegmatis was modified to allow gene knock-out in M. abscessus. Efficacy of the knock-out system was evaluated ...
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2024-08-14ZeitschriftenartikelSozial gerecht: Gesundheit – Umwelt – Klima Tagungsbericht zum Kongress Armut und Gesundheit 2024
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2024-01-20ZeitschriftenartikelGenome sequencing of the mpox virus 2022 outbreak with amplicon-based Oxford Nanopore MinION sequencing We present an amplicon-based assay for MinION Nanopore sequencing of mpox virus (MPXV) genomes from clinical specimens, obtaining high-quality results with an average genome coverage of 99% for Ct values of up to 25, and ...
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2024-02-26ZeitschriftenartikelListening to the Voices of Health Care Workers During the COVID-19 Pandemic: A Qualitative Study Providing In-Depth Insights Into Ethical and Individual Challenges In their daily practice, health care workers (HCWs) experience the effects of tensions between professional ethos and work realities, which can lead to ethical dilemmas. We aim to explore the ethical dilemmas that affected ...
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2023-12-22ZeitschriftenartikelStructure–function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophospholipase A PlaA Legionella pneumophila, the causative agent of a life-threatening pneumonia, intracellularly replicates in a specialized compartment in lung macrophages, the Legionella-containing vacuole (LCV). Secreted proteins of the ...
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2024-09-26ZeitschriftenartikelChronic Kidney Disease and Kidney Stone in a Wild Chimpanzee (Pan troglodytes verus) in Côte d'Ivoire An older wild female chimpanzee (Pan troglodytes) was found dead with a large calcium oxalate stone in the renal pelvis. Histopathological changes included glomerulosclerosis, interstitial nephritis and fibrosis, focal ...
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2024-05-28ZeitschriftenartikelOesophagostomum stephanostomum causing parasitic granulomas in wild chimpanzees (Pan troglodytes verus) of Taï National Park, Côte d'Ivoire Nematodes belonging to the genus Oesophagostomum frequently infect wild chimpanzees (Pan troglodytes) across widely separated field sites. Nodular lesions (granulomas) containing Oesophagostomum are commonly seen in the ...
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2024-10-09ZeitschriftenartikelCardiovascular Risk in Childhood is Associated With Carotid Intima-Media Thickness and Stiffness in Adolescents and Young Adults: The KiGGS Cohort Purpose: Cardiovascular risk factors are widespread among children and adolescents and may lead to accelerated vascular aging in middle adulthood. However, data are scarce on shorter-term consequences, for example, on ...
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2024-03-21ZeitschriftenartikelNeeds and feasibility of living systematic reviews (LSRs): Experience from LSRs on COVID-19 vaccine effectiveness During 2021 and 2023, a team of researchers at the Robert Koch Institute (RKI) and partnering institutions conducted two living systematic reviews (LSRs) on the effectiveness of COVID-19 vaccines in different age groups ...
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2024-11-19ZeitschriftenartikelDiagnostic electron microscopy in human infectious diseases – Methods and applications Diagnostic electron microscopy (EM) is indispensable in all cases of infectious diseases which deserve or profit from the detection of the entire pathogen (i.e. the infectious unit). The focus of its application has shifted ...
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2024-10-10Zeitschriftenartikel"A way to liberate myself": A qualitative study of perceived benefits and risks of chemsex among gay, bisexual, and other men who have sex with men in Almaty, Kazakhstan Background: In Kazakhstan, the HIV epidemic has a significant impact on marginalized groups such as gay, bisexual and other men who have sex with men (GBMSM), exacerbated by homophobic attitudes (in society) and (resulting) ...
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2024-06-12ZeitschriftenartikelStrengthening disease surveillance capacity at national level across five countries: a qualitative study Objectives: Disease surveillance is an essential component of public health and a core function of National Public Health Institutes (NPHIs), including to better prepare and respond to infectious diseases outbreaks. ...
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2024-11-20ZeitschriftenartikelHow do national immunization technical advisory groups assess and use evidence: Findings from the SYSVAC survey National immunization technical advisory groups (NITAGs) develop evidence-based vaccination recommendations. Systematic reviews (SRs) are important tools in that process, but conducting them is very resource-intensive. ...
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2024-01-16ZeitschriftenartikelCompliance of blood donors in Germany with non-sexual deferral criteria Background and Objectives: In addition to mandatory testing of blood donations, the deferral of donors in the case of various sexual and non-sexual risk exposures ensures the safety of blood products in Germany. The ...
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2024-01-05ZeitschriftenartikelEvaluation of mpox contact tracing activities and data collection in EU/EEA countries during the 2022 multicountry outbreak in nonendemic countries To control human-to-human mpox transmission during the 2022 outbreak, European Union (EU)/European Economic Area (EEA) countries conducted case investigation and contact tracing (CT). We aimed to provide an overview of CT ...
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2024-08-15ZeitschriftenartikelEvaluating the diet in Germany with two indices focusing on healthy eating and planetary healthy eating using nationwide cross-sectional food intake data from DEGS1 (2008–2011) Purpose: To improve sustainability, adjustments to current diets are necessary. Therefore, limited planetary resources are considered within the healthy reference diet proposed by the EAT-Lancet Commission. The agreement ...
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2024-09-08ZeitschriftenartikelCytosolic Factors Controlling PASTA Kinase-Dependent ReoM Phosphorylation Bacteria adapt the biosynthesis of their envelopes to specific growth conditions and prevailing stress factors. Peptidoglycan (PG) is the major component of the cell wall in Gram-positive bacteria, where PASTA kinases play ...