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Anzeige der Publikationen 10901-10920 von 12262
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2013-01-24ZeitschriftenartikelUse of multilocus variable-number tandem repeat analysis (MLVA) in eight European countries, 2012 Genotyping of important medical or veterinary prokaryotes has become a very important tool during the last decades. Rapid development of fragment-separation and sequencing technologies has made many new genotyping strategies ...
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2013-03-13ZeitschriftenartikelIdentification of a Novel Human Polyomavirus in Organs of the Gastrointestinal Tract Polyomaviruses are small, non-enveloped viruses with a circular double-stranded DNA genome. Using a generic polyomavirus PCR targeting the VP1 major structural protein gene, a novel polyomavirus was initially identified ...
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2013-02-28ZeitschriftenartikelMacrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia Influenza viruses (IV) cause pneumonia in humans with progression to lung failure and fatal outcome. Dysregulated release of cytokines including type I interferons (IFNs) has been attributed a crucial role in immune-mediated ...
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2013-02-23ZeitschriftenartikelPrevalence and comorbidity of diabetes mellitus among non-institutionalized older adults in Germany - results of the national telephone health interview survey ‘German Health Update (GEDA)’ 2009 Background: Despite the major public health impact of diabetes, recent population-based data regarding its prevalence and comorbidity are sparse. Methods: The prevalence and comorbidity of diabetes mellitus were ...
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2013-02-20ZeitschriftenartikelComparison of host cell gene expression in cowpox, monkeypox or vaccinia virus-infected cells reveals virus-specific regulation of immune response genes Background: Animal-borne orthopoxviruses, like monkeypox, vaccinia and the closely related cowpox virus, are all capable of causing zoonotic infections in humans, representing a potential threat to human health. The ...
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2013-01-24ZeitschriftenartikelFrom theory to practice: molecular strain typing for the clinical and public health setting The persistence and transmission of infectious disease is one of the most enduring and daunting concerns in healthcare. Over the years, epidemiological analysis especially of bacterial etiological agents has undergone a ...
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2013-01-30ZeitschriftenartikelModulation of Cytokine Release and Gene Expression by the Immunosuppressive Domain of gp41 of HIV-1 The transmembrane envelope protein gp41 of the human immunodeficiency virus HIV-1 plays an important role during infection allowing fusion of the viral and cellular membrane. In addition, there is increasing evidence that ...
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2012-12-20ZeitschriftenartikelTreponema pallidum Infection in the Wild Baboons of East Africa: Distribution and Genetic Characterization of the Strains Responsible It has been known for decades that wild baboons are naturally infected with Treponema pallidum, the bacterium that causes the diseases syphilis (subsp. pallidum), yaws (subsp. pertenue), and bejel (subsp. endemicum) in ...
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2012-12-07ZeitschriftenartikelInjektionsmilzbrand – neu aufgetretene Fälle bei Heroinabhängigen Injection Anthrax—a New Outbreak in Heroin UsersHintergrund: Injektionsmilzbrand ist eine seltene Erkrankung bei Heroinkonsumierenden und wird durch Bacillus anthracis verursacht. Im Jahr 2012 sind vier Fälle in Deutschland aufgetreten, wovon ein Fall tödlich verlief, ...
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2012-12-14ZeitschriftenartikelSurvey zur ärztlichen Verschreibung von Antibiotika: Ergebnisse zur akuten Zystitis in der ambulanten Versorgung A Survey of Outpatient Antibiotic Prescribing for CystitisHintergrund: Vor dem Hintergrund steigender Resistenzraten werden Einflussfaktoren auf die Verschreibung spezifischer Antibiotika bei unkomplizierter Zystitis in der ambulanten Versorgung untersucht. Methoden: Nationale ...
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2013-01-08ZeitschriftenartikelA genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic The widespread use of antibiotics in association with high-density clinical care has driven the emergence of drug-resistant bacteria that are adapted to thrive in hospitalized patients. Of particular concern are globally ...
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2013-01-31ZeitschriftenartikelMRSA Transmission on a Neonatal Intensive Care Unit: Epidemiological and Genome-Based Phylogenetic Analyses Background: Methicillin-resistant Staphylococcus aureus (MRSA) may cause prolonged outbreaks of infections in neonatal intensive care units (NICUs). While the specific factors favouring MRSA spread on neonatal wards are ...
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2013-02-12ZeitschriftenartikelWhole Genome Sequencing versus Traditional Genotyping for Investigation of a Mycobacterium tuberculosis Outbreak: A Longitudinal Molecular Epidemiological Study Background: Understanding Mycobacterium tuberculosis (Mtb) transmission is essential to guide efficient tuberculosis control strategies. Traditional strain typing lacks sufficient discriminatory power to resolve large ...
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2013-03-07ZeitschriftenartikelSubpopulations of Staphylococcus aureus Clonal Complex 121 Are Associated with Distinct Clinical Entities We investigated the population structure of Staphylococcus aureus clonal complex CC121 by mutation discovery at 115 genetic housekeeping loci from each of 154 isolates, sampled on five continents between 1953 and 2009. In ...
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2012-03-10ZeitschriftenartikelThe German Environmental Survey for Children (GerES IV): Reference values and distributions for time-location patterns of German children Children's time-location patterns are important determinants of environmental exposure and other health-relevant factors. Building on data of the German Environmental Survey for Children (GerES IV), our study aimed at ...
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2012-03-13ZeitschriftenartikelEnhanced fungal DNA-extraction from formalin-fixed, paraffin-embedded tissue specimens by application of thermal energy Determining the etiology of invasive fungal infections (IFI) is critical for patient management as fungi vary in their susceptibility to antifungals. However, the etiology remains obscure in many cases due to negative ...
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2012-03-22ZeitschriftenartikelPrevalence and patterns of morbidity among adults in Germany Zur Beschreibung von Krankheitsprävalenzen und -mustern bei Erwachsenen in Deutschland wurden Informationen zu 22 chronischen Gesundheitsproblemen bei 21.262 Personen im Alter von 18 bis 100 Jahren (51,5% Frauen) telefonisch ...
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2013-03-05ZeitschriftenartikelDetection of infections with hepatitis B virus, hepatitis C virus, and human immunodeficiency virus by analyses of dried blood spots - performance characteristics of the ARCHITECT system and two commercial assays for nucleic acid amplification Background: Nowadays, dried blood spots (DBS) are primarily used to obtain diagnostic access to risk collectives such as intravenous drug users, who are prone to infections with hepatitis B virus (HBV), hepatitis C virus ...
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2013-01-10ZeitschriftenartikelSimultaneous increase of Cryptosporidium infections in the Netherlands, the United Kingdom and Germany in late summer season, 2012 Starting August 2012, an increase in Cryptosporidium infections was reported in the Netherlands, the United Kingdom and Germany. It represented a 1.8 to 4.9-fold increase compared to previous years. Most samples were C. ...
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2013-03-07ZeitschriftenartikelLegionnaires' disease in Europe, 2009-2010 The surveillance of Legionnaires’ disease (LD) in Europe is carried out by the European Legionnaires’ Disease Surveillance Network (ELDSNet) and coordinated by the European Centre for Disease Prevention and Control (ECDC). ...