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Anzeige der Publikationen 11581-11600 von 12825
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2010-04-01ZeitschriftenartikelCharacterisation of a human cell-adapted porcine endogenous retrovirus PERV-A/C. Background: Porcine endogenous retroviruses (PERVs) pose a potential risk for xenotransplantation using pig cells, tissues or organs. A special threat comes from viruses generated by recombination between human-tropic ...
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2011-01-01ZeitschriftenartikelTowards an AIDS vaccine: The transmembrane envelope protein as target for broadly neutralizing antibodies Although the development of an effective vaccine is the main goal in the fight against AIDS, all attempts by numerous laboratories to develop a vaccine have failed so far. In addition, it is still unclear whether cytotoxic ...
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2010-05-04ZeitschriftenartikelIsotopologue Profiling of Legionella pneumophila Role of Serine and Glucose as Carbon SubstratesLegionella pneumophila (Lp) is commonly found in freshwater habitats but is also the causative agent of Legionnaires' disease when infecting humans. Although various virulence factors have been reported, little is known ...
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2010-05-04ZeitschriftenartikelBestimmung von Impfquoten und Inzidenzen von Erkrankungen anhand von Daten der Kassenärztlichen Vereinigungen Determination of Vaccination Coverage and Disease Incidence using Statutory Health Insurance DataHintergrund: Im Rahmen des KV-Sentinels, einem gemeinsamen Projekt des Robert Koch-Instituts und der 17 Kassenärztlichen Vereinigungen, werden seit 2004 pseudonymisierte Abrechnungsdaten von den Kassenärztlichen Vereinigungen ...
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2011-09-14ZeitschriftenartikelInfluenza B Virus With Modified Hemagglutinin Cleavage Site as a Novel Attenuated Live Vaccine Background: Both pandemic and interpandemic influenza is associated with high morbidity and mortality worldwide. Seasonal epidemics are caused by both influenza A and B virus strains that cocirculate with varying predominance ...
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2010-09-24ZeitschriftenartikelCharacterization of Yersinia using MALDI-TOF mass spectrometry and chemometrics. Yersinia are Gram-negative, rod-shaped facultative anaerobes, and some of them, Yersinia enterocolitica, Yersinia pseudotuberculosis, and Yersinia pestis, are pathogenic in humans. Rapid and accurate identification of ...
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2009-11-18ZeitschriftenartikelDeletion of the rat cytomegalovirus immediate-early 1 gene results in a virus capable of establishing latency, but with lower levels of acute virus replication and latency that compromise reactivation efficiency The immediate-early 1 (IE1) and IE2 proteins encoded by the major immediate-early (MIE) transcription unit of cytomegaloviruses are thought to play key roles in the switch between latent- and lytic-cycle infection. Whilst ...
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2011-02-01ZeitschriftenartikelRegional differences in body fat distributions among people with comparable body mass index: a comparison across six German population-based surveys Introduction: The mortality of circulatory diseases of the German population varies considerably across regions. The comparison of the regional distributions of cardiovascular risk factors can provide clues to the reasons ...
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2010-05-24ZeitschriftenartikelInducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis Objectives: Inducible costimulator (ICOS) and its ligand (ICOSL) regulate T and B cell responses. Glucose-6-phosphate isomerase (G6PI)-induced arthritis requires T and B lymphocytes. It was hypothesised that blocking ...
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2010-11-10ZeitschriftenartikelThe Presence of a vpu Gene and the Lack of Nef-Mediated Downmodulation of T Cell Receptor-CD3 Are Not Always Linked in Primate Lentiviruses Nef is an accessory protein critical for the ability of human and simian immunodeficiency viruses (HIV and SIV) to replicate efficiently in their respective hosts. Previous analyses of members of 15 different primate ...
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2011-09-24ZeitschriftenartikelOptimisation of expression and purification of the feline and primate foamy virus transmembrane envelope proteins using a 96 deep well screen The production of recombinant transmembrane proteins is due to their biochemical properties often troublesome and time consuming. Here the prokaryotic expression and purification of the transmembrane envelope proteins of ...
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2012-10-01ZeitschriftenartikelAutochthonous and Dormant Cryptococcus gattii Infections in Europe Until recently, Cryptococcus gattii infections occurred mainly in tropical and subtropical climate zones. However, during the past decade, C. gattii infections in humans and animals in Europe have increased. To determine ...
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2012-10-01ZeitschriftenartikelHepatitis E Virus Seroprevalence among Adults, Germany We assessed hepatitis E virus (HEV) antibody seroprevalence in a sample of the adult population in Germany. Overall HEV IgG prevalence was 16.8% (95% CI 15.6%–17.9%) and increased with age, leveling off at >60 years ...
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2012-09-01ZeitschriftenartikelEHEC O104:H4 in Germany 2011: Large outbreak of bloody diarrhea and haemolytic uraemic syndrome by shiga toxin-producing E. coli via contaminated food In the summer of 2011 Germany experienced one of the largest outbreaks of a food-borne infection caused by enterohaemorrhagic Escherichia coli (EHEC) with the serotype O104:H4. A large number of cases with bloody diarrhea ...
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2011-09-15ZeitschriftenartikelEmergence of bla CTX-M-15, qnrB1 and aac(6′)-ib-cr resistance genes in Pantoea agglomerans and enterobacter cloacae from Nigeria (sub-Saharan Africa) Besides hyper-production of chromosomal AmpC β-lactamases, the expression of plasmid-encoded extended-spectrum β-lactamases (ESBL) in Enterobacter spp has increased in recent years. In this study, we characterized 10 ...
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2007-12-01ZeitschriftenartikelPrion propagation in a nerve conduit model containing segments devoid of axons Prions, the putative causative agents of transmissible spongiform encephalopathies, are neurotropic pathogens that spread to the central nervous system via synaptically linked neural conduits upon peripheral infection. ...
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2010-12-02ZeitschriftenartikelResistente Tuberkulose Zunehmende Probleme und LösungsansätzeDie Medikamentenresistenz stellt bei der Tuberkulose (TB) ein zunehmendes Problem dar. Eine multiresistente (MDR-)TB wird bereits bei 440.000 Fällen, eine extensiv resistente (XDR-)TB bei 25.000 Fällen der weltweit über 9 ...
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2010-05-31ZeitschriftenartikelLangfristig wirksame Zweit-Therapie der HIV-Infektion bei Klassenwechsel nach virologischem Versagen unter Protease-Inhibitoren Long-term efficacy of second-line treatment of HIV infection after class change following virological failure on protease inhibitor-based therapyHintergrund: Während für die Initialtherapie der HIV-Infektion evidenzbasierte Empfehlungen für die Auswahl der antiretroviralen Kombinationstherapie (cART) bestehen, existieren zur Zweit-Therapie nach erstem virologischem ...
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2012-05-04ZeitschriftenartikelAssessment of the human medical significance of the rabies zoonosis in Germany – analysis of available data and desiderata Abschätzung der humanmedizinischen Bedeutung der Zoonose Tollwut in Deutschland – Analyse der verfügbaren Daten und DesiderateUm die humanmedizinische Bedeutung der Zoonose Tollwut in Deutschland abzuschätzen, wurden für die Jahre 2006–2010 Daten der einschlägigen „Surveillance“ und des Meldewesens sowie die in der gesetzlichen Krankenversicherung ...
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2012-05-31ZeitschriftenartikelProspective hospital-based case–control study to assess the effectiveness of pandemic influenza A(H1N1)pdm09 vaccination and risk factors for hospitalization in 2009–2010 using matched hospital and test-negative controls Background: We performed a case–control study to estimate vaccine effectiveness (VE) for prevention of hospitalization due to pandemic influenza A(H1N1)pdm09 (pH1N1) and to identify risk factors for pH1N1 and acute ...