Epidemiologie und klinischer Verlauf von Thymomen und Thymuskarzinomen
| dc.contributor.author | Universitätsmedizin Mainz | |
| dc.date.accessioned | 2023-01-05T07:34:41Z | |
| dc.date.available | 2023-01-05T07:34:41Z | |
| dc.date.issued | 2022-12 | none |
| dc.identifier.uri | http://edoc.rki.de/176904/10574 | |
| dc.language.iso | und | none |
| dc.publisher | Robert Koch-Institut | |
| dc.relation.isreferencedby | Gerber TS, Strobl S, Marx A, Roth W and Porubsky S (2024) Epidemiology of thymomas and thymic carcinomas in the United States and Germany, 1999-2019. Front. Oncol. 13:1308989. doi: 10.3389/fonc.2023.1308989 | |
| dc.relation.isreferencedby | Introduction: Mediastinal tumors, particularly non-neuroendocrine thymic epithelial tumors (TET) are relatively uncommon, posing challenges for extensive epidemiological studies. This study presents a comprehensive analysis of these tumors in the United States (US) and Germany (GER) from 1999 to 2019. Methods: Patients aged 0-19 (n=478) and ≥20 years (n=17,459) diagnosed with malignant tumors of the anterior mediastinum were identified from the Surveillance, Epidemiology, and End Results registry (SEER) and the Zentrum für Krebsregisterdaten (ZfKD) databases. Results: Among patients aged ≥20 years, TETs accounted for the most prevalent anterior mediastinal tumors (US/GER: 63%/64%), followed by lymphomas (14%/ 8%). For patients <20 years, predominant tumors included germ cell tumors (42%/14%), lymphomas (38%/53%), and TETs (10%/27%). The overall annual incidence of thymoma was 2.2/2.64 (US/GER) per million inhabitants and for thymic carcinomas 0.48/0.42. The male-to-female ratio was 1:1.09/1.03, and the mean age 59.48 ± 14.89/61.33 ± 13.94. Individuals with thymomas, but not thymic carcinomas, exhibited a 21%/29% significantly heightened risk of developing secondary malignancies compared to controls with non-thymic primary tumors. Discussion: This study provides a comparative analysis of anterior mediastinal tumors, particularly TETs, in the US and GER over the past two decades. Furthermore, it highlights a significantly elevated incidence of secondary malignancies in thymoma patients. | Englisch |
| dc.relation.isreferencedby | https://doi.org/10.3389/fonc.2023.1308989 | |
| dc.subject.ddc | 610 Medizin und Gesundheit | none |
| dc.title | Epidemiologie und klinischer Verlauf von Thymomen und Thymuskarzinomen | none |
| dc.type | StudyThesis | |
| dc.identifier.urn | urn:nbn:de:0257-176904/10574-8 | |
| dc.identifier.doi | 10.25646/10827 | |
| local.edoc.type-name | Studienarbeit |