Epidemiology of Neuroendocrine Carcinomas (NECs) in Germany

Abstract

What are the clinical and tumour characteristics of patients with neuroendocrine carcinomas (NECs) in Germany? NECs are a subgroup of high-grade neuroendocrine neoplasms characterized by poorly differentiated cytology and high proliferation rates. NECs are rare and usually present with highly aggressive clinical behaviour and can arise from a variety of organs: most commonly from the lung or gastroenteropancreatic (GEP) system, but also from other tissues such as prostate, skin and thyroid. A proportion of NECs have no identifiable primary site and are classified as cancer of unknown primary. NECs are further sub-classified according to small- or large-cell cytology. Incidence and prevalence data about NECs are mostly available from US studies. Although some information from European countries is available, more detailed prevalence estimations as well as information on other patient and tumour characteristics are needed from Germany.

1. Estimate the prevalence and incidence of NECs (SCLC, LCNEC-L and epNEC) in Germany, and 2. Describe the demographic, tumor characteristics and outcomes of patients with NECs in Germany.

Study outcomes: Prevalence and incidence of SCLC, LCNEC-L and epNEC in Germany. Patient demographics, clinical and tumor characteristics, overall survival.