Browsing Artikel in Fachzeitschriften by Author "Beekes, Michael"
Now showing items 1-20 of 28
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2007-05-25ZeitschriftenartikelAccumulation of Pathological Prion Protein PrPSc in the Skin of Animals with Experimental and Natural Scrapie Thomzig, Achim; Schulz-Schaeffer, Walter; Wrede, Arne; Wemheuer, Wilhelm; Brenig, Bertram; Kratzel, Christine; Lemmer, Karin; Beekes, MichaelPrion infectivity and its molecular marker, the pathological prion protein PrPSc, accumulate in the central nervous system and often also in lymphoid tissue of animals or humans affected by transmissible spongiform ...
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2013-06-01ZeitschriftenartikelBSE-associated Prion-Amyloid Cardiomyopathy in Primates Krasemann, Susanne; Mearini, Giulia; Krämer, Elisabeth; Wagenführ, Katja; Schulz-Schaeffer, Walter; Neumann, Melanie; Bodemer, Walter; Kaup, Franz-Josef; Beekes, Michael; Carrier, Lucie; Aguzzi, Adriano; Glatzel, MarkusPrion amyloidosis occurred in the heart of 1 of 3 macaques intraperitoneally inoculated with bovine spongiform encephalopathy prions. This macaque had a remarkably long duration of disease and signs of cardiac distress. ...
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2012-01-01ZeitschriftenartikelChronic wasting disease: Fingerprinting the culprit in risk assessments Daus, Martin L.; Beekes, MichaelTransmissible spongiform encephalopathies (prion diseases) in animals may be associated with a zoonotic risk potential for humans as shown by the occurrence of variant Creutzfeldt-Jakob disease in the wake of the bovine ...
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2014-10-25ZeitschriftenartikelDecontamination of medical devices from pathological amyloid-β-, tau- and α-synuclein aggregates Thomzig, Achim; Wagenführ, Katja; Daus, Martin L.; Joncic, Marion; Schulz-Schaeffer, Walter J.; Thanheiser, Marc; Mielke, Martin; Beekes, Michael
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2010-04-01ZeitschriftenartikelDie chronisch auszehrende Krankheit (Chronic Wasting Disease) bei Hirschartigen Beekes, MichaelDie chronisch auszehrende Krankheit (engl. „Chronic Wasting Disease“, CWD [1, 2]) ist eine transmissible spongiforme Enzephalopathie (TSE) bei Hirschartigen (Cerviden). Ursächlich ist ein unkonventionelles übertragbares ...
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2010-04-01ZeitschriftenartikelDie Scrapie (Traberkrankheit) bei kleinen Wiederkäuern Beekes, MichaelDie Scrapie (Traberkrankheit) ist eine transmissible spongiforme Enzephalopathie (TSE → Kapitel VIII – 4.0) bei Schafen und Ziegen [1, 2]. Ursächlich ist ein unkonventionelles übertragbares Agens, das der Erregerklasse ...
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2010-05-08ZeitschriftenartikelDie variante Creutzfeldt-Jakob-Krankheit (vCJK) - Epidemiologie und Schutzmaßnahmen gegen eine Übertragung von Mensch zu Mensch Beekes, MichaelDie variante Creutzfeldt-Jakob-Krankheit (vCJK) geht als zuvor unbekannte Prionkrankheit des Menschen auf zoonotische Übertragungen von Erregern der bovinen spongiformen Enzephalopathie (BSE) aus dem Rind zurück. Sie trat ...
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2008-09-29ZeitschriftenartikelFaecal shedding, alimentary clearance and intestinal spread of prions in hamsters fed with scrapie Krüger, Dominique; Thomzig, Achim; Lenz, Gudrun; Kampf, Kristin; McBride, Patricia; Beekes, MichaelShedding of prions via faeces may be involved in the transmission of contagious prion diseases. Here, we fed hamsters 10mg of 263K scrapie brain homogenate and examined the faecal excretion of disease-associated prion ...
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2009-10-28ZeitschriftenartikelFast broad-range disinfection of bacteria, fungi, viruses and prions Beekes, Michael; Lemmer, Karin; Thomzig, Achim; Joncic, Marion; Tintelnot, Kathrin; Mielke, MartinEffective disinfectants are of key importance for the safe handling and reprocessing of surgical instruments. We tested whether new formulations containing SDS, NaOH and 1-propanol (n-propanol) are simultaneously active ...
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2013-04-22ZeitschriftenartikelFoodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates Holznagel, Edgar; Yutzy, Barbara; Schulz-Schaeffer, Walter; Kruip, Carina; Hahmann, Uwe; Bierke, Pär; Torres, Juan-Maria; Kim, Yong-Sun; Thomzig, Achim; Beekes, Michael; Hunsmann, Gerhard; Löwer, JohannesRisk for human exposure to bovine spongiform encephalopathy (BSE)–inducing agent was estimated in a nonhuman primate model. To determine attack rates, incubation times, and molecular signatures, we orally exposed 18 macaques ...
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2012-01-01ZeitschriftenartikelHarnessing prions as test agents for the development of broad-range disinfectants Wagenführ, Katja; Beekes, MichaelThe development of disinfectants with broad-range efficacy against bacteria, viruses, fungi, protozoa and prions constitutes an ongoing challenge. Prions, the causative agents of transmissible spongiform encephalopathies ...
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2013-06-04ZeitschriftenartikelIn der Diskussion: Können die Alzheimer- und Parkinson-Krankheit durch selbstreplizierende Proteinpartikel übertragen werden? Beekes, Michael; Burger, ReinhardDie Alzheimer-Krankheit und die Parkinson-Krankheit gehen - wie Prionerkrankungen - mit einer Fehlfaltung und Aggregation körpereigener Proteine im zentralen Nervensystem einher, der mutmaßlich als gemeinsames molekulares ...
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2004-01-31ZeitschriftenartikelInaktivierung und Entfernung von Prionen bei der Aufbereitung von Medizinprodukten Ein Beitrag zur Prüfung und Deklaration geeigneter VerfahrenBertram, J.; Mielke, Martin; Beekes, Michael; Lemmer, Karin; Baier, Michael; Pauli, GeorgZu den Aufgaben des Robert Koch-Institutes (RKI) gehört es, gesundheitliche Risiken zu identifizieren, zu analysieren und Maßnahmen bzw. Empfehlungen zu ihrer Minimierung zu erarbeiten und zu kommunizieren. Dementsprechend ...
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2014-07-30ZeitschriftenartikelIs there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles? Beekes, Michael; Thomzig, Achim; Schulz-Schaeffer, Walter J.; Burger, ReinhardThe misfolding and aggregation of endogenous proteins in the central nervous system is a neuropathological hallmark of Alzheimer’s disease (AD), Parkinson’s disease (PD), as well as prion diseases. A molecular mechanism ...
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2011-04-01ZeitschriftenartikelPresence and seeding activity of pathological prion protein (PrP(TSE)) in skeletal muscles of white-tailed deer infected with chronic wasting disease. Daus, Martin L.; Breyer, Johanna; Wagenführ, Katja; Wemheuer, Wiebke M.; Thomzig, Achim; Schulz-Schaeffer, Walter; Beekes, MichaelChronic wasting disease (CWD) is a contagious, rapidly spreading transmissible spongiform encephalopathy (TSE), or prion disease, occurring in cervids such as white tailed-deer (WTD), mule deer or elk in North America. ...
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2018-09-12ZeitschriftenartikelPreserving prion strain identity upon replication of prions in vitro using recombinant prion protein Makarava, Natallia; Savtchenko, Regina; Lasch, Peter; Beekes, Michael; Baskakov, Ilia V.Last decade witnessed an enormous progress in generating authentic infectious prions or PrPSc in vitro using recombinant prion protein (rPrP). Previous work established that rPrP that lacks posttranslational modification ...
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2007-12-01ZeitschriftenartikelPrion propagation in a nerve conduit model containing segments devoid of axons Kratzel, Christine; Krüger, Dominique; Beekes, MichaelPrions, the putative causative agents of transmissible spongiform encephalopathies, are neurotropic pathogens that spread to the central nervous system via synaptically linked neural conduits upon peripheral infection. ...
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2016-02-01ZeitschriftenartikelPrionen III - 4Beekes, Michael
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2021-08-20ZeitschriftenartikelPropagation of CJD Prions in Primary Murine Glia Cells Expressing Human PrPc Wälzlein, Joo-Hee; Schwenke, Karla A.; Beekes, MichaelThere are various existing cell models for the propagation of animal prions. However, in vitro propagation of human prions has been a long-standing challenge. This study presents the establishment of a long-term primary ...
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2006-09-01ZeitschriftenartikelPropagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters Kratzel, Christine; Mai, Jessica; Madela, Kazimierz; Beekes, Michael; Krüger, DominiqueAs is known from various animal models, the spread of agents causing transmissible spongiform encephalopathies (TSE) after peripheral infection affects peripheral nerves before reaching the central nervous system (CNS) ...