edoc.rki.de - Open Access Publikationsserver: Recent submissions
Now showing items 921-940 of 12052
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2023-02-11ZeitschriftenartikelDistinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19 Prolonged lung pathology has been associated with COVID-19, yet the cellular and molecular mechanisms behind this chronic inflammatory disease are poorly understood. In this study, we combine advanced imaging and spatial ...
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2023-02-06ZeitschriftenartikelVisualization of SARS-CoV-2 particles in naso/oropharyngeal swabs by thin section electron microscopy Background SARS-CoV-2 replicates efficiently in the upper airways of humans and produces high loads of virus RNA and, at least in the initial phase after infection, many infectious virus particles. Studying virus ...
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2023-01-18ZeitschriftenartikelCrystal structures of OrfX1, OrfX2 and the OrfX1–OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1 Botulinum neurotoxins (BoNTs) are among the most lethal toxins known to humans, comprising seven established serotypes termed BoNT/A–G encoded in two types of gene clusters (ha and orfX) in BoNT-producing clostridia. The ...
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2023-02-10ZeitschriftenartikelSituational pathogen avoidance mediates the impact of social connectedness on preventive measures during the COVID-19 pandemic During the COVID-19 pandemic, physical distancing was one of the more important behaviours for reducing the spread of the virus. The present study investigated the influence on pathogen avoidance of familiarity with other ...
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2022-01-11ZeitschriftenartikelPrioritizing health information for national health reporting - a Delphi study of the Joint Action on Health Information (InfAct) Background Health information (HI) strategies exist in several EU Member States, however, they mainly focus on technical issues and improving governance rather than on content-related priority setting. There is also ...
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2022-01-14ZeitschriftenartikelEpidemiologie der Virushepatitiden A bis E in Deutschland Mit Virushepatitis A bis E werden verschiedene infektiöse Entzündungen des Leberparenchyms bezeichnet, die durch die Hepatitisviren A bis E (HAV, HBV, HCV, HDV und HEV) ausgelöst werden. Zwar ähneln sich die Krankheitsbilder, ...
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2022-01-14ZeitschriftenartikelSARS-CoV-2 outbreaks in hospitals and long-term care facilities in Germany: a national observational study Background Outbreaks of coronavirus disease (COVID-19) in hospitals and long-term care facilities (LTCFs) pose serious public health threats. We analysed how frequency and size of SARS-CoV-2 outbreaks in hospitals and ...
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2023-11-17Berichte und sonstige TexteHinweise zur Therapie von Lassafieber Stand 11/2023
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2022-01-13ZeitschriftenartikelCost-savings and potential cost-savings through the distribution of generic antiretroviral drugs within the statutory health insurance market of Germany between January 2017 and June 2019 Background: Recent patent losses for antiretroviral drugs (ARV) have led to the debate of cost-saving through the replacement of patented drugs with generic drugs. The split of recommended single-tablet regimens (STR) ...
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2021-12-23ZeitschriftenartikelNumerical approaches for the rapid analysis of prophylactic efficacy against HIV with arbitrary drug-dosing schemes Pre-exposure prophylaxis (PrEP) is an important pillar to prevent HIV transmission. Because of experimental and clinical shortcomings, mathematical models that integrate pharmacological, viral- and host factors are ...
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2022-01-08ZeitschriftenartikelChanges in healthcare seeking and lifestyle in old aged individuals during COVID-19 lockdown in Germany: the population-based AugUR study Background: Containment measures in the COVID-19 pandemic protected individuals at high risk, particularly individuals at old age, but little is known about how these measures affected health-related behavior of old ...
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2023-11-16ZeitschriftenartikelZur Situation bei wichtigen Infektionskrankheiten – Importierte Infektionskrankheiten 2022 Der im Epidemiologischen Bulletin 46/2023 veröffentlichte Bericht zu reiseassoziierten Erkrankungen 2022 basiert auf den Meldedaten gemäß Infektionsschutzgesetz, die dem RKI mit Datenstand 1. März 2023 übermittelt wurden. ...
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2023-11-17Berichte und sonstige TexteGrippeWeb-Wochenbericht KW 45 Kalenderwoche 45 (6.11. – 12.11.2023), Datenstand: 14.11.2023Die Aktivität akuter Atemwegserkrankungen (ARE-Inzidenz) in der Bevölkerung ist in der 45. KW 2023 im Vergleich zur Vorwoche insgesamt gestiegen und lag bei 8.200 ARE pro 100.000 Einwohner (Einw (Vorwoche: 7.600). Dabei ...
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2023-05-18ZeitschriftenartikelStrengthening national public health institutes: a systematic review on institution building in the public sector Introduction: Strong and efficient institutions are vital to the development of well-functioning governments and strong societies. The term “institution building” encompasses the creation, support, development, and ...
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2023-05-12ZeitschriftenartikelCombination of whole genome sequencing and supervised machine learning provides unambiguous identification of eae-positive Shiga toxin-producing Escherichia coli Introduction: The objective of this study was to develop, using a genome wide machine learning approach, an unambiguous model to predict the presence of highly pathogenic STEC in E. coli reads assemblies derived from ...
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2023-05-23ZeitschriftenartikelBakterielle Zoonosen mit Bedeutung für den öffentlichen Gesundheitsschutz in Deutschland – Vorkommen, Verbreitung und Übertragungswege Bakterielle zoonotische Erreger sind häufig Auslöser von Erkrankungen mit teilweise schweren Verläufen. Sie sind wechselseitig zwischen Tieren (sowohl Wild- als auch Haustieren) und Menschen übertragbar. Die Transmissionswege ...
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2023-06-01ZeitschriftenartikelDirect comparison of clinical diagnostic sensitivity of saliva from buccal swabs versus combined oro-/nasopharyngeal swabs in the detection of SARS-CoV-2 B.1.1.529 Omicron Background/Purpose: While current guidelines recommend the use of respiratory tract specimens for the direct detection of SARS-CoV-2 infection, saliva has recently been suggested as preferred sample type for the ...
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2023-05-30ZeitschriftenartikelMolecular epidemiology and disease severity of influenza virus infection in patients with haematological disorders nfluenza virus infection is a common cause of self‐limiting respiratory tract infection(RTI), however immunocompromised patients are at an increased risk for a severecourse of disease or fatal outcome. We therefore aimed ...
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2023-11-15Heft oder Ausgabe einer ZeitschriftARE-Wochenbericht KW 45 45. Kalenderwoche (6.11. bis 12.11.2023)Die ARE-Aktivität in den letzten Wochen ergibt sich aus der relativ hohen Zahl an COVID-19-Erkrankungen und den für die Jahreszeit typischen Erkältungen nach Rhinovirusinfektion. Die Zahl schwerer Atemwegserkrankungen ...
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2023-03-22ZeitschriftenartikelSpreading depolarization and angiographic spasm are separate mediators of delayed infarcts In DISCHARGE-1, a recent Phase III diagnostic trial in aneurysmal subarachnoid haemorrhage patients, spreading depolarization variables were found to be an independent real-time biomarker of delayed cerebral ischaemia. We ...