edoc.rki.de - Open Access Publikationsserver: Neuzugänge
Anzeige der Publikationen 11021-11040 von 12256
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2010-11-10ZeitschriftenartikelThe Presence of a vpu Gene and the Lack of Nef-Mediated Downmodulation of T Cell Receptor-CD3 Are Not Always Linked in Primate Lentiviruses Nef is an accessory protein critical for the ability of human and simian immunodeficiency viruses (HIV and SIV) to replicate efficiently in their respective hosts. Previous analyses of members of 15 different primate ...
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2011-09-24ZeitschriftenartikelOptimisation of expression and purification of the feline and primate foamy virus transmembrane envelope proteins using a 96 deep well screen The production of recombinant transmembrane proteins is due to their biochemical properties often troublesome and time consuming. Here the prokaryotic expression and purification of the transmembrane envelope proteins of ...
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2012-10-01ZeitschriftenartikelAutochthonous and Dormant Cryptococcus gattii Infections in Europe Until recently, Cryptococcus gattii infections occurred mainly in tropical and subtropical climate zones. However, during the past decade, C. gattii infections in humans and animals in Europe have increased. To determine ...
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2012-10-01ZeitschriftenartikelHepatitis E Virus Seroprevalence among Adults, Germany We assessed hepatitis E virus (HEV) antibody seroprevalence in a sample of the adult population in Germany. Overall HEV IgG prevalence was 16.8% (95% CI 15.6%–17.9%) and increased with age, leveling off at >60 years ...
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2012-09-01ZeitschriftenartikelEHEC O104:H4 in Germany 2011: Large outbreak of bloody diarrhea and haemolytic uraemic syndrome by shiga toxin-producing E. coli via contaminated food In the summer of 2011 Germany experienced one of the largest outbreaks of a food-borne infection caused by enterohaemorrhagic Escherichia coli (EHEC) with the serotype O104:H4. A large number of cases with bloody diarrhea ...
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2011-09-15ZeitschriftenartikelEmergence of bla CTX-M-15, qnrB1 and aac(6′)-ib-cr resistance genes in Pantoea agglomerans and enterobacter cloacae from Nigeria (sub-Saharan Africa) Besides hyper-production of chromosomal AmpC β-lactamases, the expression of plasmid-encoded extended-spectrum β-lactamases (ESBL) in Enterobacter spp has increased in recent years. In this study, we characterized 10 ...
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2007-12-01ZeitschriftenartikelPrion propagation in a nerve conduit model containing segments devoid of axons Prions, the putative causative agents of transmissible spongiform encephalopathies, are neurotropic pathogens that spread to the central nervous system via synaptically linked neural conduits upon peripheral infection. ...
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2010-12-02ZeitschriftenartikelResistente Tuberkulose Zunehmende Probleme und LösungsansätzeDie Medikamentenresistenz stellt bei der Tuberkulose (TB) ein zunehmendes Problem dar. Eine multiresistente (MDR-)TB wird bereits bei 440.000 Fällen, eine extensiv resistente (XDR-)TB bei 25.000 Fällen der weltweit über 9 ...
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2010-05-31ZeitschriftenartikelLangfristig wirksame Zweit-Therapie der HIV-Infektion bei Klassenwechsel nach virologischem Versagen unter Protease-Inhibitoren Long-term efficacy of second-line treatment of HIV infection after class change following virological failure on protease inhibitor-based therapyHintergrund: Während für die Initialtherapie der HIV-Infektion evidenzbasierte Empfehlungen für die Auswahl der antiretroviralen Kombinationstherapie (cART) bestehen, existieren zur Zweit-Therapie nach erstem virologischem ...
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2012-05-04ZeitschriftenartikelAssessment of the human medical significance of the rabies zoonosis in Germany – analysis of available data and desiderata Abschätzung der humanmedizinischen Bedeutung der Zoonose Tollwut in Deutschland – Analyse der verfügbaren Daten und DesiderateUm die humanmedizinische Bedeutung der Zoonose Tollwut in Deutschland abzuschätzen, wurden für die Jahre 2006–2010 Daten der einschlägigen „Surveillance“ und des Meldewesens sowie die in der gesetzlichen Krankenversicherung ...
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2012-05-31ZeitschriftenartikelProspective hospital-based case–control study to assess the effectiveness of pandemic influenza A(H1N1)pdm09 vaccination and risk factors for hospitalization in 2009–2010 using matched hospital and test-negative controls Background: We performed a case–control study to estimate vaccine effectiveness (VE) for prevention of hospitalization due to pandemic influenza A(H1N1)pdm09 (pH1N1) and to identify risk factors for pH1N1 and acute ...
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2012-08-31ZeitschriftenartikelMetagenomic abundance estimation and diagnostic testing on species level One goal of sequencing-based metagenomic community analysis is the quantitative taxonomic assessment of microbial community compositions. In particular, relative quantification of taxons is of high relevance for metagenomic ...
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2012-08-30ZeitschriftenartikelEvidence for airborne infectious disease transmission in public ground transport – a literature review While guidelines on contact tracing (CT) after exposure to certain infectious pathogens during air travel exist, no guidance documents are available on CT in response to potential exposure on public ground transport. We ...
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2012-01-30ZeitschriftenartikelEmergence of OXA-48-type carbapenemase-producing Enterobacteriaceae in German hospitals Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is ...
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2011-05-10ZeitschriftenartikelNeue Empfehlungen für die Umgebungsuntersuchungen bei Tuberkulose Nach der Einführung der neuen Interferon-γ-Release Assays (IGRAs) in den Empfehlungen des Deutschen Zentralkomitees zur Bekämpfung der Tuberkulose im Jahre 2007 hat sich die Datenlage für deren Einsatz beträchtlich verbessert. ...
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2012-01-18ZeitschriftenartikelEvaluation of adding a second marker to overcome Staphylococcus aureus spa-typing homoplasies The utility of sequencing a second highly variable locus in addition to the spa gene (e.g., double-locus sequence typing [DLST]) was investigated to overcome limitations of a Staphylococcus aureus single-locus typing method. ...
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2011-12-09ZeitschriftenartikelAbsence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex CC398 as a Nasal Colonizer of Pigs Raised in an Alternative System Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) ST398 isolated from pigs raised in conventional farms was previously reported. Here we report a study on 25 farms adhering to an alternative system. ...
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2011-05-31ZeitschriftenartikelImprovement of H5N1 influenza vaccine viruses: Influence of internal gene segments of avian and human origin on production and hemagglutinin content The H5N1-clade 1 influenza vaccine strain NIBRG-14 produces exceptionally low amounts of antigen, a problem recently encountered also for initial pandemic H1N1-2009 vaccine seeds. Here, we report on a strategy that may ...
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2011-11-30ZeitschriftenartikelGenome analysis of bat adenovirus 2: Indications of interspecies transmission The genome of bat adenovirus 2 was sequenced and analyzed. It is similar in size (31,616 bp) to the genomes of bat adenovirus 3 and canine adenoviruses 1 and 2. These four viruses are monophyletic and share an identical ...
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2011-05-30ZeitschriftenartikelApplication of a split luciferase complementation assay for the detection of viral protein–protein interactions Intraviral protein-protein interactions are critical for virus survival in the host. Discovery of such interactions is important to understand molecular mechanisms of viral replication and pathogenesis. The development of ...