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Browsing Artikel in Fachzeitschriften by Author "Dorner, Brigitte"
Now showing items 1-20 of 31
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2015-11-26ZeitschriftenartikelAn International Proficiency Test to Detect, Identify and Quantify Ricin in Complex Matrices Worbs, Sylvia; Skiba, Martin; Bender, Jennifer K.; Zeleny, Reinhard; Schimmel, Heinz; Luginbühl, Werner; Dorner, BrigitteWhile natural intoxications with seeds of Ricinus communis (R. communis) have long been known, the toxic protein ricin contained in the seeds is of major concern since it attracts attention of those intending criminal, ...
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2016-05-17ZeitschriftenartikelBotulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin Weisemann, Jasmin; Stern, Daniel; Mahrhold, Stefan; Dorner, Brigitte; Rummel, AndreasBotulinum neurotoxins (BoNTs) exhibit extraordinary potency due to their exquisite neurospecificity, which is achieved by dual binding to complex polysialo-gangliosides and synaptic vesicle proteins. The luminal domain 4 ...
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2019-09Teil eines BuchesChallenges in the Development of Reference Materials for Protein Toxins Zeleny, Reinhard; Rummel, Andreas; Jansson, Daniel; Dorner, BrigitteHigh molecular weight protein toxins produced by bacteria, e.g. staphylococcal enterotoxins and botulinum neurotoxins, as well as plant toxins such as ricin and abrin, are relevant analytes in different application areas: ...
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2015-11-26ZeitschriftenartikelCharacterization of Ricin and R. communis Agglutinin Reference Materials Worbs, Sylvia; Skiba, Martin; Söderström, Martin; Rapinoja, Marja-Leena; Zeleny, Reinhard; Schimmel, Heinz; Vanninen, Paula; Fredriksson, Sten-Åke; Dorner, BrigitteRicinus communis intoxications have been known for centuries and were attributed to the toxic protein ricin. Due to its toxicity, availability, ease of preparation, and the lack of medical countermeasures, ricin attracted ...
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2014-09-01Zeitschriftenartikel„Chronischer Botulismus“: Als neue Krankheit nicht belegt Dorner, Brigitte; Werber, Dirk; Dorner, Martin; Stark, Klaus; Glasmacher, Susanne; Schaade, Lars; Burger, Reinhard; Schmutzhard, ErichBisher vorgebrachte Evidenzen für ein durch Botulinum-Neurotoxine induziertes Krankheitsbild bei Landwirten sind nicht ausreichend im Hinblick auf die klinische Diagnose und den labordiagnostischen Nachweis.
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2013-01-01ZeitschriftenartikelComplexity of Botulinum Neurotoxins: Challenges for Detection Technology Dorner, Martin; Schulz, Melanie; Kull, Skadi; Dorner, BrigitteThe detection of botulinum neurotoxins (BoNT) is extremely challenging due to their high toxicity and the multiple BoNT variants. To date, seven serotypes with more than 30 subtypes have been described, and even more ...
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2012-03-07ZeitschriftenartikelDe novo subtype and strain identification of botulinum neurotoxin type B through toxin proteomics Kalb, Suzanne R.; Baudys, Jakub; Rees, Jon C.; Smith, Theresa J.; Smith, Leonard A.; Helma, Charles H.; Hill, Karen; Kull, Skadi; Kirchner, Sebastian; Dorner, Martin; Dorner, Brigitte; Pirkle, James L.; Barr, John R.Botulinum neurotoxins (BoNTs) cause the disease botulism, which can be lethal if untreated. There are seven known serotypes of BoNT, A–G, defined by their response to antisera. Many serotypes are distinguished into differing ...
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2012-11-14ZeitschriftenartikelDesinfektion von Persönlicher Schutzausrüstung Methodenentwicklung zur standardisierten Untersuchung der Wirksamkeit von Desinfektionsmitteln auf Oberflächen der Persönlichen Schutzausrüstunggegen Sporen, Viren und Toxine unter praxisnahen Bedingungenund Anwendung der Untersuchungsmethoden am Beispiel von PeressigsäureLemmer, Karin; Roder, Anja; Nattermann, Herbert; Schwebke, Ingeborg; Mielke, Martin; Dorner, Brigitte; Pauli, Georg; Grunow, RolandDie Dekontamination von Persönlicher Schutzausrüstung (PSA) in biologischer Gefahrenlage mit Verdacht auf Kontamination der PSA durch ein hochpathogenes biologisches Agens sollte effektiv, in kurzer Zeit durchführbar ...
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2016-06-29ZeitschriftenartikelDetection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry Hansbauer, Eva-Maria; Skiba, Martin; Endermann, Tanja; Weisemann, Jasmin; Stern, Daniel; Dorner, Martin; Finkenwirth, Friedrich; Wolf, Jessica; Luginbühl, Werner; Messelhäußer, Ute; Bellanger, Laurent; Woudstra, Cédric; Rummel, Andreas; Fach, Patrick; Dorner, BrigitteBotulinum neurotoxin (BoNT) serotypes C and D and their mosaic variants CD and DC cause severe cases of botulism in animal husbandry and wildlife. Epidemiological data on the exact serotype or toxin variant causing outbreaks ...
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2011-12-01ZeitschriftenartikelDetektion von bioterroristisch relevanten Toxinen am Beispiel Rizin Dorner, BrigitteZu den giftigsten bekannten Pflanzentoxinen gehört Rizin, das in den Samen des Wunderbaums Ricinus communis enthalten ist. Obwohl die Toxizität des Rizins etwa tausendfach geringer ist als die des Botulinumtoxins, zählt ...
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2016-03-01ZeitschriftenartikelDevelopment of a Genus-Specific Antigen Capture ELISA for Orthopoxviruses – Target Selection and Optimized Screening Stern, Daniel; Pauly, Diana; Zydek, Martin; Miller, Lilija; Piesker, Janett; Laue, Michael; Lisdat, Fred; Dorner, Martin; Dorner, Brigitte; Nitsche, AndreasOrthopoxvirus species like cowpox, vaccinia and monkeypox virus cause zoonotic infections in humans worldwide. Infections often occur in rural areas lacking proper diagnostic infrastructure as exemplified by monkeypox, ...
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2011-04-28ZeitschriftenartikelGeneration and characterisation of monoclonal antibodies against influenza virus A, subtype H5N1 Linke, Sonja; Neubauer, Katrin; Dorner, Martin; Dorner, Brigitte; Pauli, Georg; Schweiger, BrunhildeThe emergence of highly pathogenic avian influenza A virus (HPAIV) subtype H5N1 in 1997 has since resulted in large outbreaks in poultry and in transmission from poultry to humans, mostly in southeast Asia, but also in ...
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2015-11-26ZeitschriftenartikelGeneration and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test Weisemann, Jasmin; Krez, Nadja; Fiebig, Uwe; Worbs, Sylvia; Skiba, Martin; Endermann, Tanja; Dorner, Martin; Bergström, Tomas; Muñoz, Amalia; Zegers, Ingrid; Müller, Christian; Jenkinson, Stephen P.; Avondet, Marc-Andre; Delbrassinne, Laurence; Denayer, Sarah; Zeleny, Reinhard; Schimmel, Heinz; Åstot, Crister; Dorner, Brigitte; Rummel, AndreasThe detection and identification of botulinum neurotoxins (BoNT) is complex due to the existence of seven serotypes, derived mosaic toxins and more than 40 subtypes. Expert laboratories currently use different technical ...
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2017-07-11ZeitschriftenartikelHighly sensitive sandwich immunoassay and immunochromatographic test for the detection of Clostridial epsilon toxin in complex matrices Féraudet-Tarisse, Cécile; Mazuet, Christelle; Pauillac, Serge; Krüger, Maren; Lacroux, Caroline; Popoff, Michel R.; Dorner, Brigitte; Andréoletti, Olivier; Plaisance, Marc; Volland, Hervé; Simon, StéphanieEpsilon toxin is one of the four major toxins of Clostridium perfringens. It is the third most potent clostridial toxin after botulinum and tetanus toxins and is thus considered as a potential biological weapon classified ...
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2017-01-18ZeitschriftenartikelHistorical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature Peck, Michael W.; Smith, Theresa J.; Anniballi, Fabrizio; Austin, John W.; Bano, Luca; Bradshaw, Marite; Cuervo, Paula; Cheng, Luisa W.; Derman, Yagmur; Dorner, Brigitte; Fisher, Audrey; Hill, Karen K.; Kalb, Suzanne R.; Korkeala, Hannu; Lindström, Miia; Lista, Florigio; Lúquez, Carolina; Mazuet, Christelle; Pirazzini, Marco; Popoff, Michel R.; Rossetto, Ornella; Rummel, Andreas; Sesardic, Dorothea; Singh, Bal Ram; Stringer, Sandra C.Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with ...
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2015-02-06ZeitschriftenartikelIsolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype Kull, Skadi; Schulz, Melanie; Strotmeier, Jasmin Weisemann née; Kirchner, Sebastian; Schreiber, Tanja; Bollenbach, Alexander; Dabrowski, Piotr Wojtek; Nitsche, Andreas; Kalb, Suzanne R.; Dorner, Martin; Barr, John R.; Rummel, Andreas; Dorner, BrigitteBotulism is a severe neurological disease caused by the complex family of botulinum neurotoxins (BoNT). Based on the different serotypes known today, a classification of serotype variants termed subtypes has been proposed ...
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2016-06-16ZeitschriftenartikelOnly the complex N559-glycan in SV2C mediates high affinity binding to botulinum neurotoxin serotype A1 Mahrhold, Stefan; Bergström, Tomas; Stern, Daniel; Dorner, Brigitte; Astot, Crister; Rummel, AndreasThe extraordinary potency of botulinum neurotoxins (BoNTs) is mediated by their high neurospecificity, targeting peripheral cholinergic motoneurons leading to flaccid paralysis and successive respiratory failure. Complex ...
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2010-04-30ZeitschriftenartikelPentaplexed quantitative real-time PCR assay for the simultaneous detection and quantification of botulinum neurotoxin-producing clostridia in food and clinical samples Kirchner, Sebastian; Krämer, Melanie; Schulze, Martin; Pauly, Diana; Jacob, Daniela; Gessler, Frank; Nitsche, Andreas; Dorner, Brigitte; Dorner, MartinBotulinum neurotoxins are produced by the anaerobic bacterium Clostridium botulinum and are divided into seven distinct serotypes (A to G) known to cause botulism in animals and humans. In this study, a multiplexed ...
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2015-11-26ZeitschriftenartikelPreface Biological Toxins—Ancient Molecules Posing a Current Threat Dorner, Brigitte; Rummel, Andreas
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2015-11-26ZeitschriftenartikelQualitative and Quantitative Detection of Botulinum Neurotoxins from Complex Matrices: Results of the First International Proficiency Test Worbs, Sylvia; Fiebig, Uwe; Zeleny, Reinhard; Schimmel, Heinz; Rummel, Andreas; Luginbühl, Werner; Dorner, BrigitteIn the framework of the EU project EQuATox, a first international proficiency test (PT) on the detection and quantification of botulinum neurotoxins (BoNT) was conducted. Sample materials included BoNT serotypes A, B and ...