Browsing Artikel in Fachzeitschriften by Subject "Viral/genetics"
Now showing items 1-18 of 18
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2013-07-16ZeitschriftenartikelA Mouse Model for Human Norovirus Human noroviruses (HuNoVs) cause significant morbidity and mortality worldwide. However, despite substantial efforts, a small-animal model for HuNoV has not been described to date. Since "humanized" mice have been successfully ...
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2010-11-05ZeitschriftenartikelA novel adenovirus of Western lowland gorillas (Gorilla gorilla gorilla) Adenoviruses (AdV) broadly infect vertebrate hosts including a variety of primates. We identified a novel AdV in the feces of captive gorillas by isolation in cell culture, electron microscopy and PCR. From the supernatants ...
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2009-11-09ZeitschriftenartikelA novel herpesvirus in the sanctuary chimpanzees on Ngamba Island in Uganda Background: Recent studies in non-human primates have led to the discovery of novel primate herpesviruses. In order to get more information on herpesvirus infections in apes, we studied wild born captive chimpanzees. ...
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2010-11-03ZeitschriftenartikelAfrican great apes are naturally infected with polyomaviruses closely related to Merkel cell polyomavirus The oncogenic Merkel cell polyomavirus (MCPyV) infects humans worldwide, but little is known about the occurrence of viruses related to MCPyV in the closest phylogenetic relatives of humans, great apes. We analyzed samples ...
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2009-11-18ZeitschriftenartikelDeletion of the rat cytomegalovirus immediate-early 1 gene results in a virus capable of establishing latency, but with lower levels of acute virus replication and latency that compromise reactivation efficiency. The IE1 and IE2 proteins encoded by the major immediate-early (MIE) transcription unit of cytomegaloviruses are thought to play key roles in the switch between latent and lytic cycle infection. Whilst IE2 is essential for ...
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2009-05-14ZeitschriftenartikelDetection of hepatitis E virus in wild boars of rural and urban regions in Germany and whole genome characterization of an endemic strain Background: Hepatitis E is an increasingly diagnosed human disease in Central Europe. Besides domestic pigs, in which hepatitis E virus (HEV) infection is highly prevalent, wild boars have been identified as a possible ...
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2007-09-06ZeitschriftenartikelDiscovery of herpesviruses in multi-infected primates using locked nucleic acids (LNA) and a bigenic PCR approach Targeting the highly conserved herpes DNA polymerase (DPOL) gene with PCR using panherpes degenerate primers is a powerful tool to universally detect unknown herpesviruses. However, vertebrate hosts are often infected with ...
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2009-04-22ZeitschriftenartikelDistribution and expression of porcine endogenous retroviruses in multi-transgenic pigs generated for xenotransplantation Background: Multi-transgenic pigs produced for use in xenotransplantation have to be screened for the presence and expression of porcine endogenous retroviruses (PERV) to select animals with low PERV load. The production ...
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2009-11-01ZeitschriftenartikelEpidemiology of Hepatitis A Virus Infections, 2007-2008 Approximately 60% of hepatitis A virus infections in Germany occur in persons without a travel history to disease-endemic areas and for whom sources of infection are unknown. Recommendation of pretravel vaccination fails ...
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2009-02-28ZeitschriftenartikelFrequent foamy virus infection in free-living chimpanzees of the Taï National Park (Côte d'Ivoire) Foamy viruses are frequently found in non-human primates and apes in captivity. However, data on simian foamy virus (SFV) infection in apes from the wild are limited. Necropsy specimens were collected from 14 West African ...
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2009-10-16ZeitschriftenartikelLack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients Background: A novel gammaretrovirus named xenotropic murine leukemia virus-related virus (XMRV) has been recently identified and found to have a prevalence of 40% in prostate tumor samples from American patients carrying ...
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2009-11-18ZeitschriftenartikelLymphocryptovirus phylogeny and the origins of Epstein-Barr virus. Specimens from wild and captive primates were collected, and searched for new members of the genus Lymphocryptovirus (subfamily Gammaherpesvirinae) utilising PCR for the DNA polymerase gene. Twenty-one new viruses were ...
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2007-08-15ZeitschriftenartikelOne-step selection of Vaccinia virus-binding DNA aptamers by MonoLEX Background: As a new class of therapeutic and diagnostic reagents, more than fifteen years ago RNA and DNA aptamers were identified as binding molecules to numerous small compounds, proteins and rarely even to complete ...
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2009-04-01ZeitschriftenartikelOseltamivir-Resistant Influenza Virus A (H1N1), Europe, 2007–08 Season In Europe, the 2007-08 winter season was dominated by influenza virus A (H1N1) circulation through week 7, followed by influenza B virus from week 8 onward. Oseltamivir-resistant influenza viruses A (H1N1) (ORVs) with H275Y ...
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2010-09-14ZeitschriftenartikelPhylogenetic history demonstrates two different lineages of dengue type 1 virus in Colombia Background: Dengue Fever is one of the most important viral re-emergent diseases affecting about 50 million people around the world especially in tropical and sub-tropical countries. In Colombia, the virus was first ...
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2010-01-21ZeitschriftenartikelRegulation of human endogenous retrovirus-K expression in melanomas by CpG methylation The overall prognosis of patients with advanced melanoma is poor due to the lack of effective treatment. A key factor for successful therapy is an early detection of disease. Therefore, reliably detection methods and ...
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2009-08-06ZeitschriftenartikelTranscription of the phage-encoded Panton–Valentine leukocidin of Staphylococcus aureus is dependent on the phage life-cycle and on the host background Panton-Valentine leukocidin (PVL) is a pore-forming, bi-component toxin secreted by Staphylococcus aureus strains epidemiologically associated with diseases such as necrotizing pneumonia and skin and soft-tissue infections. ...
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2010-06-01ZeitschriftenartikelXenotropic Murine Leukemia Virus–related Gammaretrovirus in Respiratory Tract Xenotropic murine leukemia virus–related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. To identify nucleic acid sequences, we examined respiratory secretions by using ...